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Total 31 results found since Jan 2013.

Silencing of tumor necrosis factor receptor-1 in human lung microvascular endothelial cells using particle platforms for siRNA delivery.
Abstract Acute lung injury (ALI) and its most severe manifestation, acute respiratory distress syndrome (ARDS), is a clinical syndrome defined by acute hypoxemic respiratory failure and bilateral pulmonary infiltrates consistent with edema. In-hospital mortality is 38.5% for ALI, and 41.1% for ARDS. Activation of alveolar macrophages in the donor lung causes the release of pro-inflammatory chemokines and cytokines, such as TNF-α. To determine the relevance of TNF-α in disrupting bronchial endothelial cell function, we stimulated human THP-1 macrophages with lipopolysaccharide (LPS) and used the cytokine-suppleme...
Source: Current Drug Targets - July 22, 2015 Category: Drugs & Pharmacology Authors: Bai L, Andersson HA, McConnell K, Chan D, Hernandez M, Gonzalez J, Liu X, La Francesca S, Sakamoto J, Serda RE Tags: Curr Drug Targets Source Type: research

Expression of survivin in adenoid cystic carcinoma of the lacrimal gland and the effect of intervention with arsenic trioxide in vitro.
Authors: Pan Y, Xing Y, Wang H Abstract The aim of the present study was to investigate the role of survivin in adenoid cystic carcinoma of the lacrimal gland (LGACC) and the effect of arsenic trioxide (As2O3) intervention in vitro. In total, 13 patients with LGACC were recruited from Renmin Hospital of Wuhan University between 2007 and 2012. The patients were divided into different groups, namely tumor-node-metastasis (TNM)1-2 and TNM3-4, according to the TNM classification. A total of eight samples were included in the TNM1-2 group, while five samples were included in the TNM3-4 group. In addition, six patients t...
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses
The objective of this study was to explore the role of NOD2 and TLR2 in cross-presentation in human dendritic cells undertaking an unbiased screen. We have used a quantitative phosphoproteomic analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) followed by a computational analysis to identify the proteins as differentially abundant in response to NOD2 and TLR2 sensing. Validation of the phosphoproteomic analysis was performed by the detection of proteins in phosphoenriched lysates and detected by western blot. Techniques for the modulation of gene expression (shRNA and siRNA) were used to confirm the resu...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Alnylam closes $175M purchase of Merck subsidiary
Alnylam Pharmaceuticals has closed its $175 million acquisition of Sirna Therapeutics Inc., a subsidiary of Merck & Co., it said Thursday. In January, Cambridge-based Alnylam (Nasdaq: ALNY), which develops therapies based on RNA interference, entered into a stock and cash deal to buy Merck’s rights and interest of Sirna. The price was far less than the $1.1 billion Merck paid for Sirna in 2006 for the San Francisco-based biotech, which is also focused on RNAi drugs. It was a move some considered…
Source: bizjournals.com Health Care:Hospitals headlines - March 6, 2014 Category: Hospital Management Authors: Patricia Resende Source Type: research

Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer
This study reveals the role of SIRT1 on tumor invasiveness and unfavorable clinical outcomes, and we suggest its potential role as a prognostic indicator as well as a novel therapeutic target in TNBC.
Source: Clinical and Experimental Metastasis - November 19, 2015 Category: Cancer & Oncology Source Type: research

hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells
AbstractSTUDY QUESTIONHow does hCG signal in human endometrial stromal cells (ESCs) and what is its role in regulating ESC function?SUMMARY ANSWERhCG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) pathway through exchange protein activated by cyclic AMP (cAMP) (Epac) and transiently increases progesterone receptor (PR) transcript and protein expression and its transcriptional function.WHAT IS KNOWN ALREADYhCG is one of the earliest embryo-derived secreted signals in the endometrium, which abundantly expresses LH/hCG receptors. hCG signals through cAMP/protein kinase A (PKA) ...
Source: Molecular Human Reproduction - March 28, 2017 Category: Molecular Biology Source Type: research

MicroRNA-185 suppresses pancreatic cell proliferation by targeting transcriptional coactivator with PDZ-binding motif in pancreatic cancer.
Authors: Xia D, Li X, Niu Q, Liu X, Xu W, Ma C, Gu H, Liu Z, Shi L, Tian X, Chen X, Zhang Y Abstract The aim of the present study was to compare the expression of transcriptional coactivator with the PDZ-binding motif (TAZ) in pancreatic cancer (PC) patients, and to investigate the regulation mechanisms of TAZ in the proliferation of PC. PC tissues and matched peritumoral tissues, pancreatic juice and serum were collected from PC patients who underwent pancreatectomy between June 2012 and December 2015 at the Affiliated Hospital of Qingdao University (Qingdao, China). Pancreatic juice and serum were collected from ...
Source: Experimental and Therapeutic Medicine - February 6, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effects of NOB1 on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin.
Authors: Luo L, Wang Y, Yin Y, Ge J, Lu X Abstract The effects of NIN1/RPN12 binding protein 1 homolog (NOB1) on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin were investigated. Seventy-four patients with osteosarcoma who received surgical resection in The Affiliated Hospital of Southwest Medical University (Sichuan, China) from September 2013 to September 2016 were enrolled in this study. The expression of NOB1 in cancer and cancer-adjacent tissues of patients was detected by reverse transcription-polymerase chain reaction, and the relationship between NOB1 expression and...
Source: Oncology Letters - February 24, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-499a decelerates glioma cell proliferation while accelerating apoptosis through the suppression of Notch1 and the MAPK signaling pathway.
Abstract As the most common and lethal of intracranial tumors, glioma accounts for 81% of all malignant brain tumors. Research data has identified the role of microRNAs (miRs) as functional suppressers in the progression of Glioma. The present study aimed to, ascertain as to whether microRNA-499a (miR-499a) influences cell proliferation and apoptosis through the MAPK signaling pathway by targeting Notch1 in glioma. Both glioma and adjacent tissues between 2012~2016, were obtained from People's Hospital of Zhengzhou University (Henan Provincial People's Hospital). The collected glioma cells were treated with miR-44...
Source: Brain Research Bulletin - June 14, 2018 Category: Neurology Authors: Wang BQ, Yang B, Yang HC, Wang JY, Hu S, Gao YS, Bu XY Tags: Brain Res Bull Source Type: research

Expression of GRIM-19 in unexplained recurrent spontaneous abortion and possible pathogenesis
AbstractSTUDY QUESTIONIs aberrant expression of gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) associated with unexplained recurrent spontaneous abortion (URSA)?SUMMARY ANSWERGRIM-19 deficiency may regulate regulatory T cell/T helper 17 cell (Treg/Th17) balance partly through reactive oxygen species (ROS) –mammalian target of rapamycin (mTOR) signaling axis in URSA.WHAT IS KNOWN ALREADYImmunological disorders may cause impaired maternal immune tolerance to the fetus and result in fetal rejection. The differentiation of Treg and Th17 cells is controlled by phosphoinositide 3-kinase (PI3K)/Akt/mTOR...
Source: Molecular Human Reproduction - May 11, 2018 Category: Molecular Biology Source Type: research

Semaphorin 3F Promotes Transendothelial Migration of Leukocytes in the Inflammatory Response After Survived Cardiac Arrest
AbstractLeukocyte transmigration through the blood vessel wall is a fundamental step of the inflammatory response and requires expression of adhesion molecule PECAM-1. Accumulating evidence implicates that semaphorin (Sema) 3F and its receptor neuropilin (NRP) 2 are central regulators in vascular biology. Herein, we assess the role of Sema3F in leukocyte migrationin vitro andin vivo. To determine the impact of Sema3F on leukocyte recruitmentin vivo, we used the thioglycollate-induced peritonitis model. After the induction of peritonitis, C57BL/6 mice were intraperitoneally (i.p.) injected daily with recombinant Sema3F or s...
Source: Inflammation - March 14, 2019 Category: Allergy & Immunology Source Type: research

Methylxanthine derivatives promote autophagy in gastric cancer cells targeting PTEN
This study investigated the impacts of caffeine and theophylline on gastric cancer cell apoptosis and autophagy using a gastric cancer cell line (MGC-803) and a nude mouse model. Peritumoural and tumour tissues were collected from five patients diagnosed with gastric carcinoma who underwent laparoscopic radical gastrectomy at our hospital. Autophagy was suppressed in gastric cancer tumour tissue compared with peritumoural tissue. In vitro, both caffeine and theophylline effectively suppressed MGC-803 cell proliferation and migration and induced autophagy. To assess the involvement of PTEN in caffeine-mediated and theophyll...
Source: Anti-Cancer Drugs - March 16, 2019 Category: Cancer & Oncology Tags: PRECLINICAL REPORTS Source Type: research

Long noncoding RNA H19 promotes vincristine resistance in multiple myeloma by targeting Akt.
Authors: Wang Y, Xu S, Wang L, Liu J, Wang J, Zhou J Abstract Multiple myeloma is a malignant proliferation of plasma cells that results from a single clone. Manifestations include bone pain or fractures, kidney failure, susceptibility to infection, anemia, and hypercalcemia. To investigate the relationship between vincristine (VCR) resistance and Long noncoding RNA H19 (Lnc-RNA H19) in multiple myeloma (MM) this experiment was set up. For this aim, RT-PCR was used to detect the expression of lnc-RNA H19 in 60 MM patients from No.215 Hospital of Shaanxi Nuclear Industry and 50 healthy controls, and further detected...
Source: Cellular and Molecular Biology - October 14, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Re: Enhanced Therapeutic Effect of Cisplatin on the Prostate Cancer in Tumor-Bearing Mice by Transfecting the Attenuated Salmonella Carrying a Plasmid Co-Expressing p53 Gene and MDM2 siRNA
T. Jiang, C. Zhou, J. Gu, Y. Liu, L. Zhao, W. Li, G. Wang, Y. Li and L. Cai Cancer Center, First Hospital of Jilin University, Changchun, China
Source: The Journal of Urology - November 25, 2013 Category: Urology & Nephrology Authors: Anthony Atala Tags: Uro-Science Source Type: research

Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells
STUDY QUESTION Are molecular pathways reflecting the biology of small for gestational age (SGA) neonates preserved in umbilical cord-derived mesenchymal stem cells (MSCs)? SUMMARY ANSWER MSCs from SGA newborns were found to express an altered EGR-1-dependent gene network involved in the regulation of cell proliferation and oxidative stress. WHAT IS KNOWN ALREADY Individuals with suboptimal intrauterine development are at greater risk of metabolic diseases such as type II diabetes, obesity and cardiovascular disease. STUDY DESIGN, SIZE, DURATION Umbilical cords (n = 283) from the GUSTO (growing up in Singapore towards he...
Source: Human Reproduction - September 15, 2014 Category: Reproduction Medicine Authors: Sukarieh, R., Joseph, R., Leow, S. C., Li, Y., Loffler, M., Aris, I. M., Tan, J. H., Teh, A. L., Chen, L., Holbrook, J. D., Ng, K. L., Lee, Y. S., Chong, Y. S., Summers, S. A., Gluckman, P. D., Stunkel, W. Tags: Reproductive biology Source Type: research