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Infectious Disease: Coronavirus

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Total 118 results found since Jan 2013.

ASAP siRNA Therapeutics for the Therapy of COVID-19 and Other Coronaviruses
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.0c01239
Source: Molecular Pharmaceutics - May 4, 2021 Category: Drugs & Pharmacology Authors: Muhammad Imran Sajid, Muhammad Moazzam, Yeseom Cho, Shun Kato, Ava Xu, J. J. Way, Sandeep Lohan, and Rakesh K. Tiwari Source Type: research

RNAi Technology and Investigation on Possible Vaccines to Combat SARS-CoV-2 Infection
Appl Biochem Biotechnol. 2021 Apr 7. doi: 10.1007/s12010-021-03548-2. Online ahead of print.ABSTRACTCoronavirus disease of 2019 (COVID-19) pandemic, taking place globally, occurs as a result of the SARS-CoV-2 viral infection which has caused death of innumerable numbers of people and is responsible for a massive drop in the global economy. Millions of people are infected, and the death rate is also quite high in different countries. So, there is an urgent requirement of the invention of some effective and efficient drugs that can be effective against this deadly viral infection. The invention of new drugs and vaccine has b...
Source: Applied Biochemistry and Biotechnology - April 7, 2021 Category: Biochemistry Authors: Pratik Talukder Sounak Chanda Source Type: research

Identification of cellular proteins interacting with PEDV M protein through APEX2 labeling
This study is significant in that it formulates a strategy to provide new information about the mechanisms relating to the novel functions of PEDV M protein.PMID:33757879 | DOI:10.1016/j.jprot.2021.104191
Source: Journal of Proteomics - March 24, 2021 Category: Biochemistry Authors: Shijuan Dong Ruiyang Wang Ruisong Yu Bingqing Chen Fusheng Si Chunfang Xie Zhen Li Source Type: research

Viruses, Vol. 13, Pages 270: Synthetic Messenger RNA-Based Vaccines: from Scorn to Hype
o In the race for a vaccine against SARS-CoV-2, the synthetic mRNA format has been shown to be the fastest one and proved to be safe and highly efficient, even at the very low dose of a few µg per injection. The mRNA vaccines are not new: vaccines that are based on attenuated mRNA viruses, such as Mumps, Measles, and Rubella, immunize by delivering their mRNAs into the cells of the vaccinated individual, who produces the viral proteins that then prime the immune response. Synthetic mRNA in liposomes can be seen as a modern, more refined, and thereby a safer version of those live attenuated RNA viruses. The anti-COVID-...
Source: Viruses - February 9, 2021 Category: Virology Authors: Steve Pascolo Tags: Review Source Type: research

Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis
In conclusion, these data suggest that MEK-ERK1/2 signaling pathway facilitates IBV infection, probably by promoting cell survival; meanwhile, induction of DUSP6 forms a negative regulation loop to restrict ERK1/2 signaling, correlated with increased apoptosis and reduced viral load. Consequently, components of the ERK pathway, such as MEK1/2 and DUSP6, represent excellent targets for the development of antiviral drugs.
Source: Veterinary Research - January 11, 2021 Category: Veterinary Research Source Type: research

The SARS-CoV-2 receptor, Angiotensin converting enzyme 2 (ACE2) is required for human endometrial stromal cell decidualization.
Abstract The coronavirus disease 2019 (COVID-19) first appeared in December 2019 and rapidly spread throughout the world. The SARS-CoV-2 virus enters the host cells by binding to the angiotensin-converting enzyme (ACE2). Although much of the focus is on respiratory symptoms, recent reports suggest that SARS-CoV-2 can cause pregnancy complications such as pre-term birth and miscarriages; and women with COVID-19 had maternal vascular malperfusion and decidual arteriopathy in their placentas. Here, we report that ACE2 protein is expressed in both endometrial epithelial and stromal cells in the proliferative phase of ...
Source: Biology of Reproduction - November 18, 2020 Category: Reproduction Medicine Authors: Chadchan SB, Popli P, Maurya VK, Kommagani R Tags: Biol Reprod Source Type: research

A Web-Based Platform on Coronavirus Disease-19 to Maintain Predicted Diagnostic, Drug, and Vaccine Candidates.
In this study, state-of-the-art techniques have been used for predicting the potential candidates for diagnostics and therapeutics. PMID: 33136473 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - November 3, 2020 Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

Viruses, Vol. 12, Pages 924: Viral Vectors Applied for RNAi-Based Antiviral Therapy
m RNA interference (RNAi) provides the means for alternative antiviral therapy. Delivery of RNAi in the form of short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA) have demonstrated efficacy in gene silencing for therapeutic applications against viral diseases. Bioinformatics has played an important role in the design of efficient RNAi sequences targeting various pathogenic viruses. However, stability and delivery of RNAi molecules have presented serious obstacles for reaching therapeutic efficacy. For this reason, RNA modifications and formulation of nanoparticles have proven useful for non-...
Source: Viruses - August 22, 2020 Category: Virology Authors: Kenneth Lundstrom Tags: Review Source Type: research

RNAi suppressor: The hidden weapon of SARS-CoV.
Abstract The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins. In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the pres...
Source: Journal of Biosciences - July 29, 2020 Category: Biomedical Science Authors: Karjee S, Mukherjee SK Tags: J Biosci Source Type: research

Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients
On the 30th of January 2020, the World Health Organization fired up the sirens against a fast spreading infectious disease caused by a newly discovered Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and gave this disease the name COVID-19. While there is currently no specific treatment for COVID-19, several off label drugs approved for other indications are being investigated in clinical trials across the globe.In the last decade, theranostic nanoparticles were reported as promising tool for efficiently and selectively deliver therapeutic moieties (i.e. drugs, vaccines, siRNA, peptide) to target sites of infe...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Rasha Itani, Mansour Tobaiqy, Achraf Al Faraj Tags: Review Source Type: research

Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model.
CONCLUSIONS: Our pangolin coronavirus GX_P2V is a workable model for 2019-nCoV research. CEP, selamectin and mefloquine hydrochloride are potential drugs for treating 2019-nCoV infection. Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and clinical trial of CEP for treatment of 2019-nCoV infection is warranted. PMID: 32149769 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: Fan HH, Wang LQ, Liu WL, An XP, Liu ZD, He XQ, Song LH, Tong YG Tags: Chin Med J (Engl) Source Type: research

MiR-10a-5p-Mediated Syndecan 1 Suppression Restricts Porcine Hemagglutinating Encephalomyelitis Virus Replication
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a single-stranded RNA coronavirus that causes nervous dysfunction in the infected hosts and leads to widespread alterations in the host transcriptome by modulating specific microRNA (miRNA) levels. MiRNAs contribute to RNA virus pathogenesis by promoting antiviral immune response, enhancing viral replication, or altering miRNA-mediated host gene regulation. Thus, exploration of the virus–miRNA interactions occurring in PHEV-infected host may lead to the identification of novel mechanisms combating the virus life cycle or pathogenesis. Here, we discovered that the...
Source: Frontiers in Microbiology - February 19, 2020 Category: Microbiology Source Type: research

Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation
by Simon Dirmeier, Christopher D ächert, Martijn van Hemert, Ali Tas, Natacha S. Ogando, Frank van Kuppeveld, Ralf Bartenschlager, Lars Kaderali, Marco Binder, Niko Beerenwinkel Genetic perturbation screens using RNA interference (RNAi) have been conducted successfully to identify host factors that are essential for the life cycle of bacteria or viruses. So far, most published studies identified host factors primarily for single pathogens. Furthermore, often only a small subset of genes, e.g., genes encoding kinases, have been targeted. Identification of host factors on a pan-pathogen level, i.e., genes that are crucial ...
Source: PLoS Computational Biology - February 9, 2020 Category: Biology Authors: Simon Dirmeier Source Type: research