RNAi suppressor: The hidden weapon of SARS-CoV.

RNAi suppressor: The hidden weapon of SARS-CoV.
J Biosci. 2020;45:
Authors: Karjee S, Mukherjee SK
Abstract
The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins. In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. The following mini review addresses this question.
PMID: 32713862 [PubMed - in process]

Source: Journal of Biosciences - July 29, 2020 Category: Biomedical Science Authors: Karjee S, Mukherjee SK Tags: J Biosci Source Type: research