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Infectious Disease: Genital Warts

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Total 86 results found since Jan 2013.

Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk
Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide. While HPV infection can be cleared by an adequate immune response, immunocompromised individuals can develop persistent, treatment-refractory, and progressive disease. Primary immunodeficiencies (PIDs) associated with HPV-related disease include inborn errors of GATA, EVER1/2, and CXCR4 mutations, resulting in defective cellular function. People living with secondary immunodeficiency (e.g. solid-organ transplants recipients of immunosuppression) an...
Source: Frontiers in Immunology - March 7, 2023 Category: Allergy & Immunology Source Type: research

Downregulation of Sonic hedgehog signaling induces G2-arrest in genital warts
CONCLUSIONS: The downregulation of the SHh signaling promotes HPV replication and the formation of warts by inducing G2/M arrest in the keratinocytes of CA.PMID:36704875 | DOI:10.1111/srt.13265
Source: Cell Research - January 27, 2023 Category: Cytology Authors: Xiangxi Du Shan Li Kun Yang Yuchun Cao Source Type: research

siRNA-E6 sensitizes HPV-16-related cervical cancer through Oxaliplatin: an in vitro study on anti-cancer combination therapy
ConclusionInhibition of E6 oncogene expression and subsequent E6-siRNA with Oxaliplatin combination therapy could be a novel strategy for cervical cancer treatment.Graphical Abstract
Source: European Journal of Medical Research - January 21, 2023 Category: Research Source Type: research

Viruses, Vol. 14, Pages 1150: The Process of Filopodia Induction during HPV Infection
In this study, we demonstrate that after HPV16 comes into contact with a plasma membrane receptor, there are cytoskeletal changes resulting in an increase of filopodia numbers. This increase in filopodia numbers was transient and was maintained during the first two hours after virus addition. Our data show that there is a statistically significant increase in infection when filopodia numbers are increased by the addition of drug and virus simultaneously, and a decrease in virus infection when filopodia formation is inhibited. We describe that HPV16 binding results in the activation of Cdc42 GTPase that in turn results in a...
Source: Viruses - May 26, 2022 Category: Virology Authors: Alyssa Biondo Patricio I. Meneses Tags: Article Source Type: research

The Significance of CD109 Expression in Oropharyngeal Squamous Cell Carcinoma
CONCLUSION: CD109 expression is associated with poor prognosis of HPV16+ OPSCCs.PMID:35347029 | DOI:10.21873/anticanres.15687
Source: Cell Research - March 29, 2022 Category: Cytology Authors: Shohei Tsutsumi Kaho Momiyama Masaaki Ichinoe Takuya Kato Sachiyo Mogi Shunsuke Miyamoto Yoshiki Murakumo Taku Yamashita Source Type: research

HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
CONCLUSIONS: Our results give a clear molecular mechanism at the basis of HPV regulation of the DDR pathway. In particular, we show how HPV stabilizes SMAD4 to promote DDR protein expression, which may be used to facilitate viral replication and HNC onset. Moreover, we found that SMAD4 silencing in HPV-positive HNC cell lines increases sensitivity to cisplatin treatment, suggesting that HPV-positive HNC with low SMAD4 expression may be preferentially susceptible to similar treatments.PMID:35144669 | DOI:10.1186/s13046-022-02258-9
Source: Cell Research - February 11, 2022 Category: Cytology Authors: Simona Citro Claudia Miccolo Alessandro Medda Lavinia Ghiani Marta Tagliabue Mohssen Ansarin Susanna Chiocca Source Type: research

The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells
CONCLUSION: Rap1GAP may be degraded by autophagy in cervical cancer cells, but HPV infection can switch the degradation pathway from autophagy to E6AP-mediated ubiquitin-proteasome degradation. E6AP may be a key component of the switch.PMID:34952616 | DOI:10.1186/s13027-021-00409-9
Source: Cancer Control - December 25, 2021 Category: Cancer & Oncology Authors: Yinghui Wang Yihang Xie Boxuan Sun Yuwei Guo Ling Song Dawit Eman Mohammednur Chunyan Zhao Source Type: research

Cancers, Vol. 12, Pages 2963: CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer
Kim Gareth J. Thomas Head and neck squamous cell carcinoma (HNSCC) is a heterogenous disease treated with surgery and/or (chemo) radiotherapy, but up to 50% of patients with late-stage disease develop locoregional recurrence. Determining the mechanisms underpinning treatment resistance could identify new therapeutic targets and aid treatment selection. C-terminal tensin-like (CTEN) is a member of the tensin family, upregulated in several cancers, although its expression and function in HNSCC are unknown. We found that CTEN is commonly upregulated in HNSCC, particularly HPV−ve tumours. In vitro CTEN was...
Source: Cancers - October 13, 2020 Category: Cancer & Oncology Authors: Jason C. Fleming Jeongmin Woo Karwan Moutasim Christopher J. Hanley Steven J. Frampton Oliver Wood Matthew Ward Christopher H Woelk Christian H. Ottensmeier Sassan Hafizi Dae Kim Gareth J. Thomas Tags: Article Source Type: research

UHRF1 silences gelsolin to inhibit cell death in early stage cervical cancer.
Abstract Persistent infection with high-risk strains of human papillomavirus (HPV) is the primary cause of cervical cancer, the fourth most common cancer among women worldwide. Two oncoproteins encoded by the HPV genome, E6 and E7, are required for epigenetic modifications that promote cervical cancer development. We found that knockdown of HPV E6/E7 by siRNA reduced the levels of ubiquitin-like containing PHD and RING finger domain 1 (UHRF1) but increased the levels of gelsolin (GSN) in early stage cervical cancer cells. In addition, we found that UHRF1 levels were increased and GSN levels were decreased in early...
Source: Biochemical and Biophysical Research communications - April 16, 2020 Category: Biochemistry Authors: Lee HJ, Kim MJ, Kim YS, Choi MY, Cho GJ, Choi WS Tags: Biochem Biophys Res Commun Source Type: research

WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/ β-catenin pathway
ConclusionsFrom our results we conclude that WNT1, as a target of miR-34a, can promote cervical SCC cell proliferation and invasion by induction of an E-P cadherin switch via the WNT1/ β-catenin pathway. Our results may provide new options for the treatment of patients with cervical SCC.
Source: Cellular Oncology - April 15, 2020 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 11, Pages 1848: The Potential Impact of Connexin 43 Expression on Bcl-2 Protein Level and Taxane Sensitivity in Head and Neck Cancers –In Vitro Studies
This study aimed to test the role of Cx43 protein on Bcl-2 expression, tumor progression and response to taxane-based treatment in HNSCC. Human papillomavirus (HPV) negative HNSCC cell lines were tested for paclitaxel sensitivity through measuring apoptosis induction, cell viability and changes in Cx43 and Bcl-2 levels using flow cytometry, cell viability assay, immunocytochemistry and western blot. Inhibition of Cx43 expression using siRNA increased Bcl-2 protein levels in SCC25 (tongue squamous cell carcinoma) cells, while forced Cx43 expression reduced Bcl-2 levels and supported paclitaxel cytotoxicity in FaDu (hypophar...
Source: Cancers - November 21, 2019 Category: Cancer & Oncology Authors: Bianka Gurbi Di ána Brauswetter Attila Varga P ál Gyulavári Kinga P énzes J ózsef Murányi Veronika Z ámbó Ede Birtalan Tibor Kren ács David Laurence Becker Mikl ós Csala Istv án Vályi-Nagy Istv án Peták Korn él Dános Tags: Article Source Type: research

Inhibition of SMYD2 Sensitized Cisplatin to Resistant Cells in NSCLC Through Activating p53 Pathway
In conclusion, the present study elucidated that the activity of SMYD2 in NSCLC may affect the cell sensitivity to chemotherapeutic agents, especially to CDDP. The elevated SMYD2 mediated CDDP resistance and malignant phenotype in NSCLC, indicating that SMYD2 may be a useful biomarker of CDDP resistance in NSCLC. Inhibition of SMYD2 contributes to the methylation-related activation of p53 and thus results in cell apoptosis. Furthermore, combination treatment with CDDP and an SMYD2 inhibitor had a synergistically antitumor effects in a xenograft model in vivo. Given that SMYD2 has reversible effects and is a targetable prot...
Source: Frontiers in Oncology - April 25, 2019 Category: Cancer & Oncology Source Type: research

Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research