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Infectious Disease: Aspergillus
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Total 21 results found since Jan 2013.

Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis
CONCLUSION: DMF limits fungal growth by suppressing biofilm formation, conidial adherence and respiratory metabolism. It also exerts an anti-inflammatory effect on fungal keratitis by inhibiting pyroptosis, which could be regulated by Nrf2. Our results suggest that DMF plays a therapeutic role in fungal keratitis.PMID:36641891 | DOI:10.1016/j.intimp.2023.109721
Source: International Immunopharmacology - January 15, 2023 Category: Allergy & Immunology Authors: Lingwen Gu Jing Lin Qian Wang Lina Zhang Min Yin Hao Lin Hengrui Zheng Guiqiu Zhao Cui Li Source Type: research

The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
In this study, we showed that the cGAS-STING signaling pathway was activated in human corneal epithelial cells (HCECs) and in mouse corneas infected with A. fumigatus. Knockdown of cGAS reduced A. fumigatus-induced production of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IFN-β. However, reconstruction of cGAS activity restored the inflammatory response in HCECs infected with A. fumigatus. A specific cGAS inhibitor, RU.521, could also significantly inhibit A. fumigatus-induced inflammatory cytokine expression. In addition, we found that cGAS was indispensable for the autophagy flux evoked by A. fumigat...
Source: Experimental Eye Research - November 20, 2020 Category: Opthalmology Authors: Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X Tags: Exp Eye Res Source Type: research

Vitamin D reduces autophagy by regulating NF- κB resistance to Aspergillus fumigatus infection.
CONCLUSIONS: Vitamin D deficiency can aggravate the inflammatory damage in the lungs of Aspergillus fumigatus. When the body is sufficient in vitamin D, if the lungs infect Aspergillus fumigatus spores, the body may resist the infection of Aspergillus fumigatus by reducing the expression of NF-κB, inflammatory factors and autophagy. PMID: 32485309 [PubMed - as supplied by publisher]
Source: Gene - May 29, 2020 Category: Genetics & Stem Cells Authors: Hu S, Dai J, Chen X Tags: Gene Source Type: research

PHI-Nets: A Network Resource for Ascomycete Fungal Pathogens to Annotate and Identify Putative Virulence Interacting Proteins and siRNA Targets
Interactions between proteins underlie all aspects of complex biological mechanisms. Therefore, methodologies based on complex network analyses can facilitate identification of promising candidate genes involved in phenotypes of interest and put this information into appropriate contexts. To facilitate discovery and gain additional insights into globally important pathogenic fungi, we have reconstructed computationally inferred interactomes using an interolog and domain-based approach for 15 diverse Ascomycete fungal species, across nine orders, specifically Aspergillus fumigatus, Bipolaris sorokiniana, Blumeria graminis f...
Source: Frontiers in Microbiology - December 5, 2019 Category: Microbiology Source Type: research

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

Interactions of thymic stromal lymphopoietin with TLR2 and TLR4 regulate anti-fungal innate immunity in Aspergillus fumigatus-induced corneal infection.
Abstract Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like four helix bundle cytokine that plays diverse roles in the regulation of immune responses. In fungal infection, pattern recognition receptors (PRRs), including the cell surface Toll-like receptors (TLRs) and cytoplasmic NOD-like receptors, recognize pathogen-associated molecular patterns to initiate downstream signal cascades to active immune responses. Our previous studies reported that, in vitro human cornea epithelium cells represented a novel target of TSLP and that TSLP/TSLPR/STAT5 signaling played an important role in the response t...
Source: Experimental Eye Research - March 6, 2019 Category: Opthalmology Authors: Dai C, Wu J, Chen C, Wu X Tags: Exp Eye Res Source Type: research

Kruppel-like factor 4 (KLF-4) plays a crucial role in simvastatin (SVT)-induced differentiation of rabbit articular chondrocytes.
This study indicates that KLF-4 plays critical role in SVT-caused chondrocytes differentiation. PMID: 29775609 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - May 15, 2018 Category: Biochemistry Authors: Yu SM, Kim SJ Tags: Biochem Biophys Res Commun Source Type: research

HMGB1 mediates Aspergillus fumigatus-induced inflammatory response in alveolar macrophages of COPD mice via activating MyD88/NF- κB and syk/PI3K signalings.
In conclusion, HMGB1 is responsible for A. fumigatus-induced inflammatory response in COPD alveolar macrophage via Dectin-1 and TLR2/4 receptor through activating MyD88/NF-κB and syk/PI3K signalings. PMID: 29078091 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - October 24, 2017 Category: Allergy & Immunology Authors: Zhang P, Xin X, Fang L, Jiang H, Xu X, Su X, Shi Y Tags: Int Immunopharmacol Source Type: research

Nek2 siRNA therapy using a portal venous port –catheter system for liver metastasis in pancreatic cancer
In this study, the overexpression of Nek2 was identified in pancreatic cancer cell lines. Nek2 siRNA inhibited tumor growth in a subcutaneous xenograft mouse model of pancreatic cancer, prolonged the survival time in an intraperitoneal xenograft mouse model and efficiently prevented the progression of liver metastasis using a portal venous port–catheter system. Taken together, Nek2 is an effective therapeutic target in pancreatic cancer. An adequate delivery system is considered important in treating advanced pancreatic cancer, such as peritoneal dissemination and liver metastasis. Further investigations are required on ...
Source: Cancer Science - August 11, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research

Important factors mediates the adhesion of aspergillus fumigatus to alveolar epithelial cells with E-cadherin.
In conclusion, E-cadherin is a receptor for adhesion of A. fumigatus blastospores in epithelial cells. This may open a new approach to treat this fungal infection. PMID: 27347350 [PubMed]
Source: American Journal of Translational Research - June 29, 2016 Category: Research Tags: Am J Transl Res Source Type: research

Nek2 siRNA therapy using a portal venous port ‐catheter system for liver metastasis in pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - June 17, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research

Nek2 siRNA therapy using a portal venous port‐catheter system for liver metastasis in pancreatic cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - May 31, 2016 Category: Cancer & Oncology Authors: Toshio Kokuryo, Shigeru Hibino, Kazushi Suzuki, Katsutaka Watanabe, Yukihiro Yokoyama, Masato Nagino, Takeshi Senga, Michinari Hamaguchi Tags: Original Article Source Type: research

A potential link between TSLP/TSLPR/STAT5 and TLR2/MyD88/NFκB-p65 in human corneal epithelial cells for Aspergillus fumigatus tolerance
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Xiaoxiao Ren, Leyi Wang, Xinyi Wu Our previous studies reported that pattern recognition receptors (PRRs), including the cell surface Toll-like receptors (TLRs) and cytoplasmic NOD-like receptors (NLRs), recognize pathogen-associated molecular patterns (PAMPS) to initiate downstream signal cascades to active immunity responses. Thymic stromal lymphopoietin (TSLP) has recently emerged as a key cytokine in the development of type 2 adaptive immune responses. However, the crosstalk between PRRs and TSLP has not been well elucidated in Aspergil...
Source: Molecular Immunology - February 12, 2016 Category: Allergy & Immunology Source Type: research