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Source: Oncology Reports
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Total 403 results found since Jan 2013.
The long noncoding RNA FTH1P3 promotes the proliferation and metastasis of cervical cancer through microRNA ‑145.
The long noncoding RNA FTH1P3 promotes the proliferation and metastasis of cervical cancer through microRNA‑145.
Oncol Rep. 2019 Nov 20;:
Authors: Lv R, Zhang QW
Abstract
Emerging evidence has revealed that long noncoding RNAs (lncRNAs) play crucial roles in the development and progression of tumors. The present study aimed to examine the roles and illustrate the underlying mechanisms of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) in cervical cancer. The expression of lncRNA FTH1P3 and microRNA‑145 (miRNA‑145 or miR‑145) in human cervical cancer samples and cervical cancer cell lines wa...
Source: Oncology Reports - December 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Upregulation of thioredoxin and its reductase attenuates arsenic trioxide ‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress.
In conclusion, upregulation of Trx1 and TrxR1 somewhat decreased cell growth inhibition and death in ATO‑treated HPASMCs, which was accompanied by reduced oxidative stress.
PMID: 31789420 [PubMed - as supplied by publisher]
Source: Oncology Reports - December 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Cholinergic α5 nicotinic receptor is involved in the proliferation and invasion of human prostate cancer cells.
Authors: Qi JC, Xue WY, Zhang YP, Qu CB, Lu BS, Yin YW, Liu KL, Wang DB, Li W, Zhao ZM
Abstract
Nicotinic acetylcholine receptor (nAChR) subunit α5 (α5‑nAChR) is involved in tumor cell proliferation, inhibition of apoptosis, progression of metastasis, and induction of angiogenesis in certain solid tumors. However, the role of α5‑nAChR in prostate cancer cell growth and metastasis is unclear. In the present study, the role of α5‑nAChR in cell proliferation, migration, invasion and apoptosis was investigated by silencing the expression levels of α5‑nAChR in the prostate cancer cell lines DU145 and PC3. ...
Source: Oncology Reports - December 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Emodin and AZT synergistically inhibit the proliferation and induce the apoptosis of leukemia K562 cells through the EGR1 and the Wnt/ β‑catenin pathway.
Emodin and AZT synergistically inhibit the proliferation and induce the apoptosis of leukemia K562 cells through the EGR1 and the Wnt/β‑catenin pathway.
Oncol Rep. 2019 Nov 19;:
Authors: Ma W, Liu F, Yuan L, Zhao C, Chen C
Abstract
The aim of the present study was to investigate the synergistic antitumor effects of emodin and 3'‑azido‑3'‑deoxythymidine (AZT) on human chronic myeloid leukemia cells and to explore the possible underlying mechanisms. The K562 cells were treated with emodin and AZT, and the rates of cell inhibition and apoptosis were determined by MTT assay and flow cytometry, res...
Source: Oncology Reports - November 22, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Downregulation of MUTYH contributes to cisplatin ‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT.
In conclusion, the present data demonstrated that EMT activation mediated by MUTYH downregulation, by both enhancing Twist transcription and blocking its degradation, is one of the mechanisms for acquisition of CDDP resistance in ESCC.
PMID: 31578574 [PubMed - as supplied by publisher]
Source: Oncology Reports - October 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA ‑942.
LINC00461 affects the survival of patients with renal cell carcinoma by acting as a competing endogenous RNA for microRNA‑942.
Oncol Rep. 2019 Sep 12;:
Authors: Chen Y, He J, Su C, Wang H, Chen Y, Guo W, Li Y, Ding G
Abstract
The present study aimed to investigate the potential mechanisms of human miR‑942 in the sunitinib‑resistance of renal cell carcinoma (RCC). A sunitinib‑resistant OS‑RC‑2 cell line was established by continuous exposure to increasing concentrations of sunitinib for ~12 weeks. The expression levels of four miRNAs were determined by reverse transcription‑quantitative (...
Source: Oncology Reports - September 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Curcumin decreases epithelial ‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells.
Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells.
Oncol Rep. 2019 Aug 21;:
Authors: Aedo-Aguilera V, Carrillo-Beltrán D, Calaf GM, Muñoz JP, Guerrero N, Osorio JC, Tapia JC, León O, Contreras HR, Aguayo F
Abstract
Curcumin is a natural antioxidant polyphenol, which decreases epithelial‑mesenchymal transition (EMT) and cell migration in cervical cancer cells. However, the mechanism by which such a decrease occurs is unclear. It is well established that cervical cancer can be caused by high‑risk human papillomavirus (HPV), which ove...
Source: Oncology Reports - August 24, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
TNF ‑α‑mediated upregulation of SOD‑2 contributes to cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma.
TNF‑α‑mediated upregulation of SOD‑2 contributes to cell proliferation and cisplatin resistance in esophageal squamous cell carcinoma.
Oncol Rep. 2019 Jul 26;:
Authors: Zuo J, Zhao M, Liu B, Han X, Li Y, Wang W, Zhang Q, Lv P, Xing L, Shen H, Zhang X
Abstract
Intrinsic and acquired resistance of cancer to radio‑and chemotherapy is one of the major challenges in the treatment of esophageal squamous cell carcinoma (ESCC). Elevated reactive oxygen species (ROS) play an important role in the resistance to cisplatin in ESCCs. Super dismutase [Mn], mitochondrial (SOD‑2), an important primary antio...
Source: Oncology Reports - August 1, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Inhibition of ubiquitin ‑specific protease 14 promotes connexin 32 internalization and counteracts cisplatin cytotoxicity in human ovarian cancer cells.
Inhibition of ubiquitin‑specific protease 14 promotes connexin 32 internalization and counteracts cisplatin cytotoxicity in human ovarian cancer cells.
Oncol Rep. 2019 Jul 15;:
Authors: Luo H, Wang X, Ge H, Zheng N, Peng F, Fu Y, Tao L, Wang Q
Abstract
Although cisplatin is one of the most accepted therapies for ovarian cancer, recurrence and drug resistance remain problematic. Both the ubiquitin‑proteasome system (UPS) and connexin (Cx) are closely related to tumor progression. However, the role of ubiquitin‑specific protease 14 (USP14) and Cx in mediating drug resistance remains unclear. In...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Tetramethylpyrazine downregulates transcription of the CXC receptor 4 (CXCR4) via nuclear respiratory factor‑1 (Nrf‑1) in WERI‑Rb1 retinoblastoma cells.
Tetramethylpyrazine downregulates transcription of the CXC receptor 4 (CXCR4) via nuclear respiratory factor‑1 (Nrf‑1) in WERI‑Rb1 retinoblastoma cells.
Oncol Rep. 2019 Jul 15;:
Authors: Wu N, Yang Y, Yu N, Wu Y, Han X, Chen S, Zhang J, Chen X, Wu C, Yang M, Qiu J, Ge J, Yu K, Zhuang J
Abstract
Tetramethylpyrazine (TMP; an extract of the Chinese herbal medicine, Chuanxiong) has been shown to exert remarkable antiretinoblastoma (RB) effects. Based on our previous study, the target gene was found to be C‑X‑C chemokine receptor type 4 (CXCR4). CXCR4 is a prognostic marker in various types of c...
Source: Oncology Reports - July 21, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Keratin 6, induced by chronic cisplatin exposure, confers chemoresistance in human gastric carcinoma cells.
Authors: Lim SC, Parajuli KR, Han SI
Abstract
Currently, various types of keratins have been reported to be highly expressed in cancer cells and to be associated with a malignant phenotype. In the present study, it was found that expression levels of keratin 6 (K6), keratin 16 (K16), and keratin 17 (K17) were highly elevated in SNU601 cells resistant to cisplatin (SNU601‑cis2 and SNU601‑cis10), but not in the parental SNU601 cells as confirmed by quantitative PCR, immunoblotting, and immunofluorescence assays. K6 is a type II keratin and is known to form a keratin filament in conjugation with type I keratin, K1...
Source: Oncology Reports - June 25, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Role of transforming growth factor β1 in the inhibition of gastric cancer cell proliferation by melatonin in vitro and in vivo.
Authors: Liu H, Zhu Y, Zhu H, Cai R, Wang KF, Song J, Wang RX, Zhou RX
Abstract
Transforming growth factor β (TGF‑β) is a polypeptide growth factor with various biological activities, and is widely distributed in various tissues. In mammals, TGF‑β has three isoforms: TGF‑β1, 2, and 3, of which TGF‑β1 is most abundant in the TGF‑β family. TGF‑β1 is closely related to the occurrence and development of tumors. A large number of previous studies have shown that melatonin can inhibit a variety of malignancies. Thus, the aim of the present study was to investigate the role of TGF‑β1 in the melatonin...
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Sulfasalazine ‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor.
In conclusion SAS could trigger ferroptosis in breast cancer cells, especially in cells with low ER expression. Therefore, SAS is a potential agent for breast cancer treatment.
PMID: 31173262 [PubMed - as supplied by publisher]
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways.
TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways.
Oncol Rep. 2019 Apr 02;:
Authors: Han YG, Yun M, Choi M, Lee SG, Kim H
Abstract
Histone H2B monoubiquitination has been shown to play critical roles in diverse cellular processes including DNA damage response. Although recent data indicate that H2B monoubiquitination is strongly connected with tumor progression and regulation, the implications of this modification in lung adenocarcinoma are relatively unknown. In the present study, we demonstrated the clinical implication of H2B monoubiquitination and the potential role of...
Source: Oncology Reports - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MicroRNA ‑92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells.
MicroRNA‑92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells.
Oncol Rep. 2019 Feb 19;:
Authors: Alcantara KMM, Garcia RL
Abstract
Inactivation of the tumor suppressor protein Merlin leads to the development of benign nervous system tumors in neurofibromatosis type2 (NF2). Documented causes of Merlin inactivation include deleterious mutations in the encoding neurofibromin2 gene (NF2) and aberrant Merlin phosphorylation leading to proteasomal degradation. Rare somatic NF2 mutations have also been detected in com...
Source: Oncology Reports - March 4, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
