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Source: Oncology Reports

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Total 403 results found since Jan 2013.

Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch ‑1‑dependent manner.
In conclusion, NE may enhance the malignant biological behaviors of PDAC via activating the Notch‑1 pathway. PMID: 30226612 [PubMed - as supplied by publisher]
Source: Oncology Reports - September 20, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

STAT1 ‑HDAC4 signaling induces epithelial‑mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2.
STAT1‑HDAC4 signaling induces epithelial‑mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2. Oncol Rep. 2018 Sep 12;: Authors: Kaowinn S, Kaewpiboon C, Koh SS, Krämer OH, Chung YH Abstract Our previous studies have shown that the novel oncogene, cancer upregulated gene 2 (CUG2), activates STAT1, which is linked to anticancer drug resistance, induces epithelial‑mesenchymal transition (EMT) and cancer stem cell‑like phenotypes as determined by MTT, migration and sphere formation assays. We thus aimed to ascertain whether the activation of STAT1 by CUG2...
Source: Oncology Reports - September 20, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

C ‑C chemokine receptor type 2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer.
C‑C chemokine receptor type 2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer. Oncol Rep. 2018 Aug 17;: Authors: Li H, Li H, Li XP, Zou H, Liu L, Liu W, Duan T Abstract C‑C chemokine receptor type 2 (CCR2) is aberrantly expressed in a variety of tumor cells, and participates in the regulation of tumor cell progression, metastasis and immune escape. However, the mechanism of action of CCR2 in liver cancer remains unclear. In the present study, the aim was to elucidate the molecular mechanism underlying the regulation of epithelia...
Source: Oncology Reports - August 24, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR ‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3.
In conclusion, we revealed that miR‑197 modulates IGFBP3 and therefore plays a critical role in regulating CRC migration and invasion. PMID: 30106114 [PubMed - as supplied by publisher]
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibitor of apoptosis protein ‑like protein‑2: A novel growth accelerator for breast cancer cells.
Inhibitor of apoptosis protein‑like protein‑2: A novel growth accelerator for breast cancer cells. Oncol Rep. 2018 Aug 03;: Authors: Zhu L, Zhou W, Zhu X, Xiang S, Wang S, Peng Y, Lu B, Tang P, Chen Q, Wu M, Peng X, Chen Z, Sun Z, Yang K, Xiang M, Yu D Abstract Although the inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) has been shown as a serological biomarker for breast cancer, its effect on breast cancer cell growth remains elusive. The present study aimed to determine the role of ILP‑2 in breast cancer cell growth. We used immunohistochemistry to analyze ILP‑2 expression in 59 ...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Enolase-phosphatase 1 as a novel potential malignant glioma indicator promotes cell proliferation and migration.
Authors: Su L, Yang K, Li S, Liu C, Han J, Zhang Y, Xu G Abstract Enolase-phosphatase 1 (ENOPH1), is an enzyme that is involved in polyamine biosynthesis and is associated with stress responses. However, little is known about its role in the pathophysiology of glioma. In the present study, we examined the expression and function of ENOPH1 in human glioma tissues and cell lines. Western blot, qPCR and immunohistochemistry analysis were performed to investigate the expression of the ENOPH1 protein in glioma tissues in 86 patients. The 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT), wound heali...
Source: Oncology Reports - August 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy ‑dependent pathway in human synovial sarcoma cells.
Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy‑dependent pathway in human synovial sarcoma cells. Oncol Rep. 2018 Jul 25;: Authors: Zhu J, Cai Y, Xu K, Ren X, Sun J, Lu S, Chen J, Xu P Abstract Beclin1 is an important autophagy‑related prot-ein, which is involved in both autophagy and apoptosis. In recent years, the antitumor effect of Beclin1 has received increased attention. In the present study, we established a stable Beclin1‑overexpressing cell line with SW982 human synovial sarcoma cells. We found that Beclin1 overexpression decreased the cell viabi...
Source: Oncology Reports - August 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Upregulation and activation of p53 by erastin ‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells.
Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells. Oncol Rep. 2018 Jul 20;: Authors: Huang C, Yang M, Deng J, Li P, Su W, Jiang R Abstract The tumour‑suppressor protein p53 is a key regulator of multiple cellular processes and exerts its tumour‑suppressor function by inducing apoptotic cell death. However, emerging evidence indicates that p53 is also involved in inducing ferroptosis, which is a unique iron‑dependent form of non‑apoptotic cell death triggered by the RAS‑selective lethal small...
Source: Oncology Reports - August 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis.
Authors: Wang H, He Z, Xia L, Zhang W, Xu L, Yue X, Ru X, Xu Y Abstract PSMB4, proteasome subunit β4, is a member of the ubiquitin-proteasome family, and is elevated in a variety of malignancies. However, the expression level and related mechanism of PSMB4 in breast cancer remains unclear. Therefore, the present study investigated the expression level of PSMB4 in eight pairs of breast cancer and adjacent normal tissues. In addition, the relationship between the expression of PSMB4 and the clinical data of 92 breast cancer patients was discussed. First, it was found that PSMB4 expression was obviously upregulated...
Source: Oncology Reports - August 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of CDCA5 inhibits cancer progression and serves as a prognostic biomarker for hepatocellular carcinoma.
Authors: Wang J, Xia C, Pu M, Dai B, Yang X, Shang R, Yang Z, Zhang R, Tao K, Dou K Abstract Cell division cycle associated 5 (CDCA5) has been associated with the progression of several types of cancers. However, its possible role and mechanism in hepatocellular carcinoma (HCC) remain unknown. In the present study, immunohistochemical staining and real‑time PCR were used to assess CDCA5 protein and mRNA levels in clinical samples. Statistical analysis was performed to explore the clinical correlation between CDCA5 protein expression and clinicopathological features and overall survival in HCC patients. Cell coun...
Source: Oncology Reports - July 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Androgen receptor induces EPHA3 expression by interacting with transcription factor SP1.
This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism. We determined mRNA and protein levels of EPHA3 and AR signaling‑related genes in the PCa cell line 22Rv1 by reverse transcription‑polymerase chain reaction (RT‑PCR) and western blotting, respectively. The EPHA3 mRNA and protein levels were both found to be elevated by dihydrotestosterone (DHT) hormone in a dose‑ and time‑dependent manner, as AR and prostate‑specific antigen (PSA) expression were increased. Similarly, EPHA3 protein levels were also increased in the PCa cel...
Source: Oncology Reports - June 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

HBsAg/ β2GPI activates the NF‑κB pathway via the TLR4/MyD88/IκBα axis in hepatocellular carcinoma.
HBsAg/β2GPI activates the NF‑κB pathway via the TLR4/MyD88/IκBα axis in hepatocellular carcinoma. Oncol Rep. 2018 Jun 19;: Authors: Jing X, Tian Z, Gao P, Xiao H, Qi X, Yu Y, Ding X, Yang L, Zong L Abstract Chronic hepatitis B virus (HBV) infection remains one of the leading causes of hepatocellular carcinoma (HCC) globally. However, the mechanism underlying the mediation by HBV surface proteins (HBsAgs) of the early steps in the virus life cycle and following HCC development is unclear. β‑2‑glycoprotein I (β2GPI) specifically interacts with HBsAg and demonstrates high expression during t...
Source: Oncology Reports - June 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Girdin regulates the proliferation and apoptosis of pancreatic cancer cells via the PI3K/Akt signalling pathway.
Authors: Wang S, Lei Y, Cai Z, Ye X, Li L, Luo X, Yu C Abstract Girdin functions as an Akt phosphorylation enhancer (APE), which expedites the proliferation and survival of many types of tumours. However, the influence of Girdin on pancreatic cancer and the underlying molecular mechanisms have yet to be uncovered. Hence, in the present study, we sought to elucidate the function of Girdin in pancreatic cancer malignancy, particularly its role in pancreatic cancer cell proliferation, migration and apoptosis. Immunohistochemistry (IHC) was used to evaluate Girdin expression in pancreatic cancer tissues and to analyse ...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

RAD52 motif ‑containing protein 1 promotes non‑small cell lung cancer cell proliferation and survival via cell cycle regulation.
This study aimed to investigate the role of RDM1 in the progression of non‑small cell lung cancer (NSCLC). We found elevated RDM1 mRNA and protein expression in NSCLC tissues and cell lines compared to levels in normal lung cells. RDM1 protein expression in lung cancer tissues was found to correlate with tumor size, histological differentiation, lymph node metastasis and tumor‑node‑metastasis (TNM) stage. Knockdown of the RDM1 gene with siRNA significantly reduced the cellular proliferation rate and increased apoptosis in the human NSCLC cell line, NCI‑H1299. Compared to wild‑type NCI‑H1299 cells, RDM1 knockdow...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Montelukast, a cysteinyl leukotriene receptor antagonist, inhibits the growth of chronic myeloid leukemia cells through apoptosis.
Authors: Zovko A, Yektaei-Karin E, Salamon D, Nilsson A, Wallvik J, Stenke L Abstract The clinical outcome for patients with chronic myeloid leukemia (CML) has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs). However, their curative potential appears limited, probably as a consequence of TKI-resistant leukemic stem cells (LSCs) that persist as a result of aberrant pathways independent of the well-established oncoprotein Bcr-Abl. One such pathway involves signaling through leukotrienes (LTs), bioactive compounds that have been suggested to play a role in several other malignancies. ...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research