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Source: Oncology Reports
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Total 403 results found since Jan 2013.
Activating transcription factor 4 regulates hypoxia inducible factor 1 α in chronic hypoxia in pancreatic cancer cells
Oncol Rep. 2023 Jan;49(1):14. doi: 10.3892/or.2022.8451. Epub 2022 Nov 23.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates hypoxia-inducible factors (HIFs) that mediate cellular responses to adapt to low oxygen environments. Hypoxia also causes endoplasmic reticulum (ER) stress, increasing activating transcription factor 4 (ATF4), a master regulator of the unfolded protein response (UPR) pathway that mediates cellular response to ER stress. ATF4 is overexpressed in PDAC and is assoc...
Source: Oncology Reports - November 23, 2022 Category: Cancer & Oncology Authors: Nancy T Chee Candace H Carriere Zachary Miller Scott Welford Shaun P Brothers Source Type: research
Retracted siRNA ‑mediated inhibition of endogenous brain‑derived neurotrophic factor gene modulates the biological behavior of HeLa cells
Oncol Rep. 2023 Jan;49(1):1. doi: 10.3892/or.2022.8438. Epub 2022 Nov 4.ABSTRACTSubsequently to the publication of the above article and a Corrigendum that was published to indicate corrections made to Fig. 7 (DOI: 10.3892/or.2021.7922; published online on January 5, 2021), a concerned reader drew the Editor's attention to the fact that, comparing between a pair of panels in the Figure, there was an overlapping section of data; moreover, this overlapping section contained apparent anomalies that could not be easily accounted for through a straightforward re‑use of one of the data panels. The authors conceded that there w...
Source: Oncology Reports - November 4, 2022 Category: Cancer & Oncology Authors: Chun-Yan Sun Zhang-Bo Chu Jing Huang Lei Chen Jian Xu Ao-Shuang Xu Jun-Ying Li Yu Hu Source Type: research
5 ‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis
Oncol Rep. 2022 Oct;48(4):186. doi: 10.3892/or.2022.8401. Epub 2022 Sep 9.ABSTRACTIron is an essential nutrient that facilitates cell proliferation and growth, and it can contribute to tumor growth. Although iron chelators have shown great potential in preclinical cancer models, they can cause adverse side‑effects. The aim of the present study was to determine whether treatment with 5‑aminolevurinic acid (5‑ALA) has antitumor effects in bladder cancer, by reduction of mitochondrial iron without using an iron chelator, through activation of heme synthesis. T24 and MGH‑U3 cells were treated with 5‑ALA. Ferrochelata...
Source: Oncology Reports - September 9, 2022 Category: Cancer & Oncology Authors: Yasushi Nakai Yoshihiro Tatsumi Shunta Hori Yosuke Morizawa Kota Iida Kenta Onishi Makito Miyake Yuki Oda Takuya Owari Tomomi Fujii Sayuri Onishi Nobumichi Tanaka Kiyohide Fujimoto Source Type: research
