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Source: Oncology Reports
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Total 403 results found since Jan 2013.
Inhibition of CCR7 promotes NF- κB-dependent apoptosis and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.
In conclusion, upregulation of CCR7 promoted cell proliferation and inflammation in A549 cells. In conclusion, inhibition of CCR7 via siRNA treatment promoted cell apoptosis and suppressed the inflammatory response and TGF-β1‑induced EMT, which may be associated with NF-κB signaling.
PMID: 28339080 [PubMed - as supplied by publisher]
Source: Oncology Reports - March 27, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Silencing BMI1 radiosensitizes human breast cancer cells by inducing DNA damage and autophagy.
Authors: Griffith J, Andrade D, Mehta M, Berry W, Benbrook DM, Aravindan N, Herman TS, Ramesh R, Munshi A
Abstract
Overexpression of BMI1 in human cancer cells, a member of the polycomb group of repressive complexes, correlates with advanced stage of disease, aggressive clinico-pathological behavior, poor prognosis, and resistance to radiation and chemotherapy. Studies have shown that experimental reduction of BMI1 protein level in tumor cells results in inhibition of cell proliferation, induction of apoptosis and/or senescence, and increased susceptibility to cytotoxic agents and radiation therapy. Although a role...
Source: Oncology Reports - March 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Enhanced expression of PKM2 associates with the biological properties of cancer stem cells from A549 human lung cancer cells.
Authors: Guo CY, Yan C, Luo L, Goto S, Urata Y, Xu JJ, Wen XM, Kuang YK, Tou FF, Li TS
Abstract
Cancer cells express the M2 isoform of glycolytic enzyme pyruvate kinase (PKM2) for favoring the survival under a hypoxic condition. Considering the relative low oxygen microenvironment in stem cell niche, we hypothesized that an enhanced PKM2 expression associates with the biological properties of cancer stem cells. We used A549 human lung cancer cell line and surgical resected lung cancer tissue samples from patients for experiments. We confirmed the co-localization of PKM2 and CD44, a popular marker for cancer stem ce...
Source: Oncology Reports - March 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Authors: Shiiba M, Yamagami H, Yamamoto A, Minakawa Y, Okamoto A, Kasamatsu A, Sakamoto Y, Uzawa K, Takiguchi Y, Tanzawa H
Abstract
Resistance to anticancer medications often leads to poor outcomes. The present study explored an effective approach for enhancing chemotherapy targeted against human cancer cells. Real-time quantitative real-time polymerase chain reaction (qRT-PCR) analysis revealed overexpression of members of aldo-keto reductase (AKR) 1C family, AKR1C1, AKR1C2, AKR1C3, and AKR1C4, in cisplatin, cis-diamminedichloroplatinum (II) (CDDP)-resistant human cancer cell lines, HeLa (cervical cancer cells) an...
Source: Oncology Reports - March 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells.
Authors: Wang H, Li S, Luo X, Song Z, Long X, Zhu X
Abstract
Colorectal adenocarcinoma is the third most common cancer worldwide. PARP6, a novel member of the poly(ADP-ribose) polymerases (PARPs) and survivin, a member of the family of inhibitor of apoptosis (IAP) proteins are associated with a poor prognosis in various types of cancers. However, limited evidence exists regarding the interaction between PARP6 and survivin in colorectal adenocarcinoma. In the present study, we used the paired samples of 20 patients with colorectal adenocarcinoma to detect the expression of PARP6 and survivin in both tumor and adjac...
Source: Oncology Reports - March 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
EPAC1 overexpression is a prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer.
This study investigated the correlations between the expression of EPAC1 and various clinicopathologic parameters as well as the survival of the patients with gastric cancer (GC). The patient cohort in this study consisted of 141 cases of GC that presented from 1999 through 2011; documented clinicopathologic parameters and clinical outcomes were available for all cases. Immunoblotting, immunohistochemistry and quantitative real-time PCR were used to examine EPAC1 expression in gastric cells and tissues. siRNA technology was used to study the effect of EPAC1 knockdown on cell proliferation and invasion. An increase in EPAC...
Source: Oncology Reports - March 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Authors: Xu H, Qian M, Zhao B, Wu C, Maskey N, Song H, Li D, Song J, Hua K, Fang L
Abstract
RAB1A acts as an oncogene in various cancers, and emerging evidence has verified that RAB1A is an mTORC1 activator in hepatocellular and colorectal cancer, but the role of RAB1A in breast cancer remains unclear. In this investigation, RAB1A siRNA was successfully transfected in MDA-MB-231 and BT-549 human triple-negative breast cancer cells, and verified by real‑time quantitative polymerase chain reaction and western blotting. Then, MTT cell proliferation, colony formation, cell invasion and wound healing assays were per...
Source: Oncology Reports - February 14, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma.
Authors: Liu J, Su Z, Zeng Y, Zhang H, Yang S, Liu G
Abstract
Evidence reveals that microRNAs (miRNAs) play essential roles in hepatocellular carcinoma (HCC) tumorigenesis. In the present study, we identified an essential role for miR-922 in the development of HCC. We found that miR-922 was significantly upregulated in HCC cells and clinical tissues. Gain and loss of function studies indicated that miR-922 significantly promoted HCC cell proliferation. We subsequently identified that cylindromatosis (CYLD) was a target gene of miR-922. Moreover, miR-922 decreased CYLD expression, subsequently upregulating the expre...
Source: Oncology Reports - February 14, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1.
Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1.
Oncol Rep. 2017 Mar;37(3):1394-1400
Authors: Yu J, Wang X, Li Y, Tang B
Abstract
Tanshinone IIA (TSN) exhibits a variety of anticancer effects. However, whether it inhibits gastric cancer (GC) cell proliferation and migration and the mechanism remain unclear. In the present study, different concentrations of TSN were co-incubated with SGC-7901 cells. The pcDNA-FOXM1 or FOXM1-siRNA plasmid was transfected into cells before treatment with 5 µg/l TSN. The proliferation and migration abilities of the S...
Source: Oncology Reports - February 14, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Corrigendum Loss of Runt ‑related transcription factor 3 induces resistance to 5‑fluorouracil and cisplatin in hepatocellular carcinoma.
[Corrigendum] Loss of Runt‑related transcription factor 3 induces resistance to 5‑fluorouracil and cisplatin in hepatocellular carcinoma.
Oncol Rep. 2017 Mar;37(3):1921
Authors: Kataoka J, Shiraha H, Horiguchi S, Sawahara H, Uchida D, Nagahara T, Iwamuro M, Morimoto H, Takeuchi Y, Kuwaki K, Onishi H, Nakamura S, Takaki A, Nouso K, Yagi T, Yamamoto K, Okada H
Abstract
Following the publication of this article, we realize that there were some errors in the manuscript. Details of the experiments describing the gene silencing of RUNX3 with small interfering RNA (siRNA) were erroneously included in thi...
Source: Oncology Reports - February 14, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Synergistic combination of YS-1 and adriamycin inhibits human renal cancer through ERK1/2 signaling pathway in vitro and in vivo.
In this study, we found the combination between YS-1 and ADM, performed higher anticancer activity on 786-O human RCC cells in vitro and in vivo, than that reported on its anti-angiogenesis effect compared with monotherapy of ADM. Our data showed that when combined with ADM, YS-1 promoted the sensitivity of 786-O cells to ADM. The combination of YS-1 and ADM also inhibited cell proliferation, but without affecting cell apoptosis. We found that ADM monotherapy treatment notably upregulated the activity of extracellular signal-regulated kinase ERK1 and ERK2 (ERK1/2), but when combined with YS-1, the p-ERK1/2 level was redu...
Source: Oncology Reports - January 19, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
TRIM29 promotes progression of thyroid carcinoma via activating P13K/AKT signaling pathway.
Authors: Xu J, Li Z, Su Q, Zhao J, Ma J
Abstract
Thyroid cancer (TC) is a common malignancy of the endocrine system. Abnormal expression of tripartite motif-containing 29 (TRIM29) has been reported to promote tumorigenesis and predict poor prognosis in several human malignancies. The aim of this study was to assess the involvement of TRIM29 in the significance and prognosis of TC. Fifty-six tumor samples and their clinicopathological para-meters were obtained from TC patients; the expression level of TRIM29 was detected by RT-qPCR and western blotting. TRIM29 expression was knocked down by small interfering RNA (s...
Source: Oncology Reports - January 19, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2.
Authors: Zhang H, Du X, Sun TT, Wang CL, Li Y, Wu SZ
Abstract
Prostatic carcinoma is the most aggressive tumor in adult men. Warburg effect is an important characteristic of tumor cell metabolism including prostate cancer cells, in which hexokinase 2 (HK2), a major rate-limiting enzyme involved in Warburg effect, is selectively upregulated. The lectin PCL is a mannose binding lectin which induces tumor cell apoptosis and autophagy. In the present study, we report that PCL could lower glucose consumption and lactate production, shift the Warburg effect by inhibiting the expression of HK2 in PC3 cells and the suppres...
Source: Oncology Reports - January 19, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Silencing of GP73 inhibits invasion and metastasis via suppression of epithelial-mesenchymal transition in hepatocellular carcinoma.
Authors: Yang Y, Liu Q, Zhang H, Zhao H, Mao R, Li Z, Ya S, Jia C, Bao Y
Abstract
Epithelial-mesenchymal transition (EMT) is associated with invasion and metastasis of cancer cells. Golgi protein 73 (GP73) is a serum biomarker for hepatocellular carcinoma (HCC) and our previous study demonstrated that the expression of GP73 correlated with aggressive behavior and EMT molecules in HCC. However, its role in metastatic mechanism of HCC is not clear. The aim of this study was to investigate the effect of GP73 on invasion and migration, and underlying mechanism of GP73 involved in EMT of HCC. The expression of GP73 was ...
Source: Oncology Reports - January 12, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Expression of glia maturation factor γ is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro.
Authors: Wang H, Chen Z, Chang H, Mu X, Deng W, Yuan Z, Yao F, Liu Y, Mai R, Wu B
Abstract
Glia maturation factor γ (GMFG) functions to reorganize the actin cytoskeleton and appears to play a causative role in cell migration and adherence. The present study assessed GMFG expression in colorectal cancer cells and tissue specimens and then explored the role of GMFG in colorectal cancer progression in vitro. GMFG protein was highly expressed in colorectal cancer tissues and a metastatic colon cancer cell line. Knockdown of GMFG expression using GMFG siRNA or anti-GMFG antibody decreased the capacity of colon cancer...
Source: Oncology Reports - January 12, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
