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Source: Oncology Reports
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Total 403 results found since Jan 2013.
miR ‑218 promotes apoptosis of SW1417 human colon cancer cells by targeting c‑FLIP.
miR‑218 promotes apoptosis of SW1417 human colon cancer cells by targeting c‑FLIP.
Oncol Rep. 2018 May 23;:
Authors: Meng Q, Chen Y, Lian B, Shang Y, Yang H
Abstract
MicroRNAs (miRNAs) are suggested to act as either tumor oncogenes or tumor suppressors in different types of cancer. miRNA‑218 (miR‑218) is a type of short, non-coding RNA which is involved in gastric cancer development. In the present study, we evaluated the functions of miR‑218 in SW1417 human colon cancer cells and its potential mechanisms. Following overexpression of miR‑218 in human colon cancer cells, cell viability was d...
Source: Oncology Reports - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
ClC-3 chloride channel protein induces G1 arrest in hepatocellular carcinoma Hep3B cells.
In conclusion, we demonstrated that ClC-3 can arrest the cell cycle at the G1 phase to inhibit cell proliferation, suggesting that ClC-3 has the potential to be a novel target for HCC therapy and potentially improve the prognosis of HCC patients.
PMID: 29749557 [PubMed - as supplied by publisher]
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Suppression of RRM2 inhibits cell proliferation, causes cell cycle arrest and promotes the apoptosis of human neuroblastoma cells and in human neuroblastoma RRM2 is suppressed following chemotherapy.
Authors: Li J, Pang J, Liu Y, Zhang J, Zhang C, Shen G, Song L
Abstract
Ribonucleotide reductase regulatory subunit M2 (RRM2) is a rate‑limiting enzyme for DNA synthesis and repair. RRM2 has vital roles in controlling the progression of cancer. In the present study, we investigated the RRM2 level in neuroblastoma tissues, analyzed its relationship with clinicopathological characteristics of neuroblastoma patients, and explored the effect of RRM2 on the biological functions of neuroblastoma cells. RRM2 levels in 67 pairs of neuroblastoma and matched adjacent non‑cancerous tissues were detected by qRT‑PCR, and...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma.
Authors: Bi C, Jiang B
Abstract
The morbidity of colorectal cancer (CRC) increases annualy, which accounts to higher mortality worldwide. Therefore, it is important to study the pathogenesis of colon cancer. Ribophorin II (RPN2), part of the N-oligosaccharyltransferase complex, is highly expressed in CRC. In the present study, we investigated whether RPN2 can regulate apoptosis, migration and invasion by RNA interference in CRC and sought to clarify the molecular mechanism involved. Based on previous research, an abnormal high expression of RPN2 was observed in CRC tissues and cell lines by real-time (RT)-PCR, im...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Protein arginine methyltransferase 5 is implicated in the aggressiveness of human hepatocellular carcinoma and controls the invasive activity of cancer cells.
Authors: Jeon JY, Lee JS, Park ER, Shen YN, Kim MY, Shin HJ, Joo HY, Cho EH, Moon SM, Shin US, Park SH, Han CJ, Choi DW, Gu MB, Kim SB, Lee KH
Abstract
Protein arginine methyltransferase 5 (PRMT5) is a protein that catalyzes transfer of methyl groups to the arginine residues of proteins and is involved in diverse cellular and biological responses. While the participation of PRMT5 in cancer progression has been increasingly documented, its association with the invasive phenotype currently remains poorly understood. In the present study, we revealed that PRMT5 is overexpressed in human hepatocellular carcinoma (HCC...
Source: Oncology Reports - May 12, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
HSPB8 promotes cancer cell growth by activating the ERK ‑CREB pathway and is indicative of a poor prognosis in gastric cancer patients.
In conclusion, we provide evidence that HSPB8 promotes cancer cell growth by activating the ERK‑CREB pathway and may serve as a potential prognostic factor in GC patients.
PMID: 29693129 [PubMed - as supplied by publisher]
Source: Oncology Reports - April 26, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MALAT1 affects ovarian cancer cell behavior and patient survival.
In conclusion, our results indicated that MALAT1 was overexpressed in EOC. Silencing of MALAT1 decreased EOC cell viability and inhibited EOC cell migration and invasion. These data revealed that MALAT1 may serve as a new therapeutic target of human EOC.
PMID: 29693187 [PubMed - as supplied by publisher]
Source: Oncology Reports - April 26, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Protein kinase, membrane ‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer.
Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer.
Oncol Rep. 2018 Apr 13;:
Authors: Jeong D, Kim H, Kim D, Ban S, Oh S, Ji S, Kang D, Lee H, Ahn TS, Kim HJ, Bae SB, Lee MS, Kim CJ, Kwon HY, Baek MJ
Abstract
The protein kinase, membrane‑associated tyrosine/threonine 1 (PKMYT1) is known to inhibit precocious entry into mitosis by phosphorylating CDK1 at Thr14 and Tyr15 residues. However, the functional importance of PKMYT1 in colorectal cancer (CRC) remains unknown. Thus, it is important to elucidate whether PKYMT1 is indispensable in ...
Source: Oncology Reports - April 18, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
GPNMB silencing suppresses the proliferation and metastasis of osteosarcoma cells by blocking the PI3K/Akt/mTOR signaling pathway.
In conclusion, we provided evidence that GPNMB silencing regulated the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/Akt/mTOR signaling pathway. Thus, GPNMB may be a potential therapeutic target for osteosarcoma treatment.
PMID: 29620278 [PubMed - as supplied by publisher]
Source: Oncology Reports - April 6, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma.
Authors: Cheng R, Zhu S, Guo S, Min L, Xing J, Guo Q, Li P, Zhang S
Abstract
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in China, and is associated with high morbidity and mortality. However, the molecular mechanisms that control ESCC tumorigenicity and metastasis remain unclear. Here, we report that the RNA splicing factor, NONO, is an important regulator of ESCC growth, apoptosis and invasion. NONO protein levels were dramatically upregulated in ESCC when compared with that in adjacent benign esophageal squamous epithelium. Particularly, NONO expression was statistically high...
Source: Oncology Reports - April 6, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
miR-130b promotes bladder cancer cell proliferation, migration and invasion by targeting VGLL4.
Authors: Liu X, Kong C, Zhang Z
Abstract
Bladder cancer (BCa) is the most common urological cancer, and more and more evidence suggests that microRNAs (miRNAs) play an important role in BCa pathogenesis. Aberrant miR-130b expression has been reported in several types of cancers. The aim of the present study was to elucidate the effects of miR-130b on BCa progression. miR‑130b expression in BCa cell lines and tissues was detected using real-time PCR (RT-PCR), and vestigial-like protein 4 (VGLL4) expression in tissue specimens and BCa cells that had been transfected with miR-130b mimics and inhibitors was det...
Source: Oncology Reports - March 9, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Platelet ‑derived growth factor receptor‑β gene expression relates to recurrence in colorectal cancer.
In conclusion, PDGFR‑β expression was a risk factor for recurrence in patients with CRC and PDGFR inhibitor may be a useful therapeutic agent for CRC.
PMID: 29498405 [PubMed - as supplied by publisher]
Source: Oncology Reports - March 3, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Knockdown of EPCR inhibits the proliferation and migration of human gastric cancer cells via the ERK1/2 pathway in a PAR-1-dependent manner.
Authors: Wang Q, Yang H, Zhuo Q, Xu Y, Zhang P
Abstract
Endothelial protein C receptor (EPCR) has been implicated in the carcinogenesis of diverse tumor types. This tumor-promoting effect of EPCR is associated with the upregulation of activated protein C and the activation of protease-activated receptor 1 (PAR-1). However, the exact role of EPCR in gastric cancer (GC) and the mechanisms underlying the regulation of EPCR remain elusive. In the present study, we investigated the effects of EPCR on human GC cells, as well as the underlying mechanisms. An siRNA inference system was used to knock down the expressio...
Source: Oncology Reports - February 28, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Knockdown of angiopoietin-like 4 inhibits the development of human gastric cancer.
In conclusion, these findings suggest that ANGPTL4 may be a new potential therapeutic target for GC.
PMID: 29436683 [PubMed - as supplied by publisher]
Source: Oncology Reports - February 14, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF ‑7 cells in vitro and in vivo and its mechanism of action.
Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF‑7 cells in vitro and in vivo and its mechanism of action.
Oncol Rep. 2018 Jan 26;:
Authors: Hu B, Meng X, Zhang Y, Hossain MM, Wu L, Zhang Y, Peng X, Zhang X
Abstract
A disintegrin and metalloprotease 17 (ADAM17) is highly expressed in many malignant tumors and is closely related to their development. We showed in a previous study that silencing of ADAM17 by siRNA inhibited the growth of MCF‑7 breast cancer cells in vitro and in vivo. In the present study, we investigated the effects of ADAM17-short ha...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
