Filtered By:
Source: Oncology Reports
This page shows you your search results in order of date. This is page number 8.
Order by Relevance | Date
Total 403 results found since Jan 2013.
Cellular and radiobiological effects of carbonic anhydrase IX in human breast cancer cells.
In conclusion, combination of CAIX inhibition and irradiation is a promising treatment strategy against breast cancer with hypoxia‑induced CAIX expression.
PMID: 30720123 [PubMed - as supplied by publisher]
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLC γ.
TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ.
Oncol Rep. 2019 Jan 30;:
Authors: Zhang X, Shi G, Gao F, Liu P, Wang H, Tan X
Abstract
Pancreatic cancer (PC), a malignancy of the digestive system, has one of the highest rates of metastasis and mortality. It is characterized by the detachment, migration, implantation and infiltration of tumor cells to form metastases or recurrent foci. Tetraspanin 1 (TSPAN1), a novel member of the TSPAN superfamily, is highly expressed in many types of cancer, including gastric, colon, liver and esophageal cancer. It has also ...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8 ‑AS1:28.
MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8‑AS1:28.
Oncol Rep. 2019 Feb 01;:
Authors: Zhang Y, Li F, Chen J
Abstract
As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8‑AS1:28, or lnc‑PSD4‑1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8‑AS1:28 in PTC is still unknown. Therefore, the present study aimed to investigate the functions of PAX8‑AS1:28 in PTC, and to explore the possible mechanisms of action...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
SPAG9/MKK3/p38 axis is a novel therapeutic target for liver cancer.
Authors: Luo S, Ren B, Zou G, Liu J, Chen W, Huang Y, Chen X, Fu Y
Abstract
Sperm‑associated antigen 9 (SPAG9) is a biomarker and potential therapeutic target for several cancers; however, its involvement in liver cancer progression is not clear. The aim of the present study was to determine whether SPAG9 regulates proliferation of liver cancer. Immunohistochemistry and cell immunofluorescence were used to confirm the expression and the localization of SPAG9 in human liver cancer tissues and the liver cancer‑derived HepG2 cells. A small interfering RNA (siRNA) designed to target SPAG9 was transiently transfecte...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Upregulation of thyroid hormone receptor interactor 13 is associated with human hepatocellular carcinoma.
Upregulation of thyroid hormone receptor interactor 13 is associated with human hepatocellular carcinoma.
Oncol Rep. 2018 Oct 04;:
Authors: Ju L, Li X, Shao J, Lu R, Wang Y, Bian Z
Abstract
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. Thyroid hormone receptor interactor 13 (TRIP13) has been reported to promote nonhomologous end joining (NHEJ). However, the role of TRIP13 in the molecular pathogenesis of HCC remains to be elucidated. The aim of the present study was to investigate the role and potential mechanism of TRIP13 in HCC. Real-time PCR a...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Inhibition of autophagy enhances cinobufagin ‑induced apoptosis in gastric cancer.
Inhibition of autophagy enhances cinobufagin‑induced apoptosis in gastric cancer.
Oncol Rep. 2018 Oct 31;:
Authors: Xiong X, Lu B, Tian Q, Zhang H, Wu M, Guo H, Zhang Q, Li X, Zhou T, Wang Y
Abstract
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. Cinobufagin is one of the active ingredients in the anticancer Chinese medicine called Chan Su, which was demonstrated to be an effective treatment for gastric cancer. Increasing evidence shows that inhibition of autophagy has a pro‑apoptotic effect on human gastric cancer cells. The aim of the present study...
Source: Oncology Reports - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MicroRNA ‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7.
MicroRNA‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7.
Oncol Rep. 2018 Dec 06;:
Authors: Tang X, Yang W, Shu Z, Shen X, Zhang W, Cen C, Cao L, Zhang M, Zheng S, Yu J
Abstract
Hepatocellular carcinoma (HCC) is a globally prevalent malignancy associated with a poor patient prognosis. We investigated the relationship between microRNA‑223 (miR‑223) expression and the sensitivity of HCC cells to sorafenib treatment. miR‑223 expression was determined in HCC cell lines with differential sorafenib sensitivity using reverse transcription‑quantitative PCR. miR‑...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc ‑1 cancer stem‑like cells.
Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc‑1 cancer stem‑like cells.
Oncol Rep. 2018 Dec 06;:
Authors: Peng G, Tang Z, Xiang Y, Chen W
Abstract
Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchymal transition (EMT), which has been reported to promote can...
Source: Oncology Reports - December 13, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Leukocyte ‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC.
Leukocyte‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC.
Oncol Rep. 2018 Nov 20;:
Authors: Jingushi K, Uemura M, Nakano K, Hayashi Y, Wang C, Ishizuya Y, Yamamoto Y, Hayashi T, Kinouchi T, Matsuzaki K, Kato T, Kawashima A, Ujike T, Nagahara A, Fujita K, Ueda K, Tsujikawa K, Nonomura N
Abstract
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, responsible for approximately 90‑95% of cases. We previously reported a novel method that enables direct extraction of extracellular vesicles (EVs) from surgically resected viable tissues, yielding what...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Molecular mechanism of LKB1 in the invasion and metastasis of colorectal cancer.
Authors: Chen Y, Liu Y, Zhou Y, You H
Abstract
The occurrence of colorectal cancer (CRC) is associated with a variety of oncogenes and tumor‑suppressor genes. As a tumor‑suppressor gene, the liver kinase B1 gene (LKB1, also known as serine/threonine kinase 11, STK11) is closely related to tumor angiogenesis, invasion and metastasis, but its molecular mechanisms remain unclear. The aim of the present study was to investigate the effects of LKB1 on the invasion and metastasis of CRC, and to explore its molecular mechanisms. By detecting the expression of LKB1 in CRC, we can provide a reference index for diagnosin...
Source: Oncology Reports - December 1, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Evironmental pollutant perfluorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence.
Authors: Zhang Z, Song N, Peng Y, Fan Z, Han M, Zhao M, Dong T, Liu S
Abstract
The role of perfluorodecanoic acid (PFDA) in gastric carcinogenesis and its mechanism remains unknown. Our previous research revealed that PFDA regulated the growth of human gastric cells. However, its core molecules and basic mechanisms are still not clear. In the present study, cDNA microarrays were used to determine mRNA changes in AGS cells after treatment with PFDA. DAVID analysis of the genes with >2‑fold increased expression in microarray data revealed five genes which were involved in cancer pathways. The most upregulated g...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Glutathione S ‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer.
Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer.
Oncol Rep. 2018 Nov 09;:
Authors: Zou M, Hu X, Xu B, Tong T, Jing Y, Xi L, Zhou W, Lu J, Wang X, Yang X, Liao F
Abstract
The roles of glutathione S‑transferase pi 1 (GSTP1), glutathione S‑transferase mu 2 (GSTM2) and glutathione S‑transferase alpha 1 (GSTA1) in cisplatin (DDP)‑resistance of solid cancer cells (A549/DDP, SKOV3/DDP and SGC7901/DDP) were compared following expression downregulation with small interfering RNAs (siRNAs). DDP cytotoxicity was reflected by...
Source: Oncology Reports - November 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
E26 transformation (ETS) ‑specific related transcription factor‑3 (ELF3) orchestrates a positive feedback loop that constitutively activates the MAPK/Erk pathway to drive thyroid cancer.
In conclusion, the present study demonstrated ELF3 to be a potential prognostic marker for patients with thyroid cancer. Notably, ELF3 was demonstrated to form a positive feedback loop with MAPK pathways leading to the progression of BRAF‑mutant thyroid cancer.
PMID: 30365150 [PubMed - as supplied by publisher]
Source: Oncology Reports - October 27, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Taurolidine promotes cell apoptosis by enhancing GRIM ‑19 expression in liver cancer.
Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer.
Oncol Rep. 2018 Sep 18;:
Authors: Li F, Qi J, Qin C, Fu Z, Ren W
Abstract
Taurolidine (TRD) is a substance derived from the amino sulfonic acid taurine, which was originally used to treat peritonitis and catheter‑associated bloodstream infections, due to its antimicrobial and anti‑inflammatory properties. A recent study reported the anticancer function of TRD in malignant tumors; however, the effects and mechanisms of TRD in liver cancer remain unclear. The present study aimed to investigate the effects and mecha...
Source: Oncology Reports - October 3, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Biological functions and clinical significance of the newly identified long non ‑coding RNA RP1‑85F18.6 in colorectal cancer.
Biological functions and clinical significance of the newly identified long non‑coding RNA RP1‑85F18.6 in colorectal cancer.
Oncol Rep. 2018 Sep 10;:
Authors: Ma Y, Chen Y, Lin C, Hu G
Abstract
The biological functions of long non‑coding RNAs (lncRNAs) in cancer have not been fully elucidated. The present study demonstrated that the expression of a newly identified lncRNA, RP1‑85F18.6, was upregulated in colorectal cancer (CRC) tissues and cell lines. Knockdown of lncRNA RP1‑85F18.6 served a key role in tumor inhibition, reduced cell proliferation and invasion, disrupted the cell cycle, and i...
Source: Oncology Reports - September 20, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
