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Condition: Schizophrenia
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Total 19 results found since Jan 2013.

Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases
CONCLUSION: This study provides the rationale for the possible innovative use of penfluridol as a newly identified small-molecule drug for TNFα-driven diseases, such as inflammatory arthritis and colitis.PMID:35045889 | DOI:10.1186/s13075-021-02713-6
Source: Cell Research - January 20, 2022 Category: Cytology Authors: Yue-Hong Chen Rong-Han Liu Ya-Zhou Cui Aubryanna Hettinghouse Wen-Yu Fu Lei Zhang Chen Zhang Chuan-Ju Liu Source Type: research

TNIK influence the effects of antipsychotics on Wnt/ β-catenin signaling pathway
ConclusionsThe influence of TNIK on the effects of antipsychotics may be partly through Wnt/ β-catenin signaling pathway.
Source: Psychopharmacology - August 5, 2021 Category: Psychiatry Source Type: research

Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway
This study investigated whether apolipoprotein A5 (apoA5) and sortilin, two interactive factors involved in NAFLD pathogenesis, are implicated in olanzapine-induced NAFLD. In our study, at week 8, olanzapine treatment successfully induced hepatic steatosis in female C57 BL/6 J mice, which was independent of body weight gain. Likewise, olanzapine effectively mediated hepatocyte steatosis in HepG2 cells characterized by substantially elevated intracellular lipid droplets. Increased plasma triglyceride concentration and decreased plasma apoA5 levels were observed in mice treated with 8-week olanzapine. Surprisingly, olanzapin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 19, 2021 Category: Drugs & Pharmacology Authors: Rong Li Wenqiang Zhu Piaopiao Huang Yang Yang Fei Luo Wen Dai Li Shen Wenjing Pei Xiansheng Huang Source Type: research

Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior
It is well known that only a small proportion of the human genome code for proteins; the rest belong to the family of RNAs that do not code for protein and are known as non-coding RNAs (ncRNAs). ncRNAs are further divided into two subclasses based on size: 1) long non-coding RNAs (lncRNAs; >200 nucleotides) and 2) small RNAs (<200 nucleotides). Small RNAs contain various family members that include microRNAs (miRNAs), small interfering RNAs (siRNAs), piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and small nuclear RNAs (snRNAs). The roles of ncRNAs, especially lncRNAs and miRNAs, are well documented ...
Source: Frontiers in Psychiatry - September 14, 2020 Category: Psychiatry Source Type: research

Regulatory Role of lncRNA NONHSAT089447 in the Dopamine Signaling Pathway in Schizophrenic Patients.
CONCLUSIONS Our results revealed that the lncRNA NONHSAT089447 participated in the dopamine signaling pathway via upregulation of DRDs. PMID: 31180069 [PubMed - in process]
Source: Medical Science Monitor - June 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Olig2 Silence Ameliorates Cuprizone-Induced Schizophrenia-Like Symptoms in Mice.
CONCLUSIONS Cuprizone-induced schizophrenia-like symptoms involved olig2 upregulation. The silence of olig2 could prevent changes, likely through regulating MBP, CNPase, and GFAP expressions. PMID: 28989170 [PubMed - in process]
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells.
Abstract Dysregulated expression and function of dopamine D2 receptors (D2Rs) are implicated in drug addiction, Parkinson's disease and schizophrenia. In the current study, we examined whether D2Rs are modulated by regulator of G protein signaling 2 (RGS2), a member of the RGS family that regulates G protein signaling via acceleration of GTPase activity. Using neuroblastoma 2a (N2A) cells, we found that RGS2 was immunoprecipitated by aluminum fluoride-activated Gαi2 proteins. RGS2 siRNA knockdown enhanced membrane [(35)S] GTPγS binding to activated Gαi/o proteins, augmented inhibition of cAMP accumulation and i...
Source: Neuropharmacology - August 11, 2016 Category: Drugs & Pharmacology Authors: Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R Tags: Neuropharmacology Source Type: research

GSE79255 Gene-expression profiles after siRNA knockdown and overexpression of bromodomian containing 1 (BRD1) in HEK293T cells
Conclusion: Our results show that BRD1 interacts with chromatin remodeling proteins, e.g. PBRM1, as well as histone modifiers, e.g. MYST2 and SUV420H1. We find that BRD1 primarily binds in close proximity to transcription start sites and regulates expression of numerous genes, many of which are involved with brain development and susceptibility to mental disorders. Our findings indicate that BRD1 acts as a regulatory hub in a comprehensive schizophrenia risk network which plays a role in many brain regions throughout life, implicating e.g.striatum, hippocampus, and amygdala at mid fetal stages.
Source: GEO: Gene Expression Omnibus - March 16, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Neuregulin 1 Regulates EAAC1 Cell Biology
Neuregulin 1 (NRG1) is a trophic factor that is thought to have important roles in the regulating brain circuitry. Recent studies suggest that NRG1 regulates synaptic transmission, although the precise mechanisms remain unknown. Here we report that NRG1 influences glutamate uptake by increasing the protein level of excitatory amino acid carrier (EAAC1). Our data indicate that NRG1 induced the up-regulation of EAAC1 in primary cortical neurons with an increase in glutamate uptake. These in vitro results were corroborated in the prefrontal cortex (PFC) of mice given NRG1. The stimulatory effect of NRG1 was blocked by inhibit...
Source: Journal of Biological Chemistry - August 14, 2015 Category: Chemistry Authors: Yu, H.-N., Park, W.-K., Nam, K.-H., Song, D.-Y., Kim, H.-S., Baik, T.-K., Woo, R.-S. Tags: Neurobiology Source Type: research

GSE62085 The Pitt-Hopkins syndrome/schizophrenia susceptibility gene TCF4 regulates human neural progenitor cell proliferation
Contributors : Matthew J Hill ; Katherinne Navarrete ; Aleksandra Maruszak ; Gemma M McLaughlin ; Richard Killick ; James Docker ; Ricardo Sainz Fuertes ; Brenda P Williams ; Nicholas J BraySeries Type : Expression profiling by arrayOrganism : Homo sapiensTranscription factor 4 (TCF4, also known as E2-2, SEF2, ITF2 and bHLHb19) is an E-protein basic helix-loop-helix transcription factor that is highly expressed in foetal as well as adult human brain. Common variants in the TCF4 gene show genome-wide significant association with schizophrenia and the eye disease Fuchs corneal dystrophy, while rare TCF4 deletions and loss-of...
Source: GEO: Gene Expression Omnibus - April 1, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala
Publication date: Available online 26 February 2015 Source:Brain, Behavior, and Immunity Author(s): Stacey L. Kigar , Liza Chang , Anthony P. Auger Precise regulation of the epigenome during perinatal development is critical to the formation of species-typical behavior later in life. Recent data suggests that Gadd45b facilitates active DNA demethylation by recruiting proteins involved in base excision repair (BER), which will catalyze substitution of 5-methyl-cytosine (5mC) for an unmodified cytosine. While a role for Gadd45b has been implicated in both hippocampal and amygdalar learning tasks, to the best of our knowled...
Source: Brain, Behavior, and Immunity - March 4, 2015 Category: Neurology Source Type: research

Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala.
Abstract Precise regulation of the epigenome during perinatal development is critical to the formation of species-typical behavior later in life. Recent data suggests that Gadd45b facilitates active DNA demethylation by recruiting proteins involved in base excision repair (BER), which will catalyze substitution of 5-methyl-cytosine (5mC) for an unmodified cytosine. While a role for Gadd45b has been implicated in both hippocampal and amygdalar learning tasks, to the best of our knowledge, no study has been done investigating the involvement of Gadd45b in neurodevelopmental programming of social behavior. To address...
Source: Brain, Behavior, and Immunity - February 26, 2015 Category: Neurology Authors: Kigar SL, Chang L, Auger AP Tags: Brain Behav Immun Source Type: research

Clozapine Induces Autophagic Cell Death in Non-Small Cell Lung Cancer Cells
Conclusions: Clozapine inhibits cell proliferation by inducing autophagic cell death in two non-small cell lung carcinoma cell lines. These findings may provide insights into the relationship between clozapine use and the lower incidence of lung cancer among patients with schizophrenia.Cell Physiol Biochem 2015;35:945-956
Source: Cellular Physiology and Biochemistry - February 5, 2015 Category: Cytology Source Type: research

Adenylyl cyclase-5 in the dorsal striatum function as a molecular switch for the generation of behavioral preferences for cue-directed food choices
Conclusions: Our results show that the gain and loss of behavioral preferences for a specific cue-directed option were regulated by specific cellular factors in the dorsal striatum, such that the preferred food choices were switched on when either the mGluR3-AC5 pathway was inactive or the mGluR1 pathway was active, whereas the preferred food-choices were switched off when mGluR1 or its downstream pathway was suppressed. These results identify the AC5 and mGluR system in the dorsal striatum as molecular on/off switches to direct decisions on behavioral preferences for cue-oriented options.
Source: Molecular Brain - November 7, 2014 Category: Neuroscience Authors: Hannah KimTae-Kyung KimJi-Eun KimJin-Young ParkYunjin LeeMinkyung KangKyoung-Shim KimPyung-Lim Han Source Type: research