Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases

CONCLUSION: This study provides the rationale for the possible innovative use of penfluridol as a newly identified small-molecule drug for TNFα-driven diseases, such as inflammatory arthritis and colitis.PMID:35045889 | DOI:10.1186/s13075-021-02713-6

Source: Cell Research - January 20, 2022 Category: Cytology Authors: Yue-Hong Chen Rong-Han Liu Ya-Zhou Cui Aubryanna Hettinghouse Wen-Yu Fu Lei Zhang Chen Zhang Chuan-Ju Liu Source Type: research