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Condition: Osteoporosis

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Total 136 results found since Jan 2013.

High ‐mobility group AT‐Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling
This study suggests that HMGA1 plays a role in osteoblast commitment and mediates the function of NFIX through transcriptionally activating canonical Wnt signaling.© AlphaMed Press 2021Significance StatementBone homeostasis depends largely on the number and function of osteoblasts. Osteoblasts and adipocytes are both derived from bone marrow mesenchymal stem cells, and a competitive relationship exists between adipogenesis and osteogenesis. We have identified a novel nuclear factor I/X (NFIX)-high-mobility group AT-Hook 1 (HMGA1)-wingless-type MMTV integration site (Wnt)/ β-catenin regulatory axis that governs the cell f...
Source: Stem Cells - May 24, 2021 Category: Stem Cells Authors: Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3 β/β-catenin pathway
AbstractThe apoptosis of mature osteocytes is the main factor causing damage to the microstructure of cortical bone in glucocorticoid-induced osteoporosis (GIOP). Our previous research found damaged areas and empty osteocytes lacunae in the tibial cortical bone of GIOP mice. However, the specific mechanism has not been clarified. Recently, a study showed that the quality of the cortical bone significantly increased by knocking out Notum, a gene encoding α/β hydrolase. However, it is not clear whether Notum affects cortical bone remodeling by participating in glucocorticoids (GCs)-induced apoptosis of osteocytes. The pres...
Source: Journal of Molecular Histology - July 23, 2021 Category: Laboratory Medicine Source Type: research

HDAC6 inactivates Runx2 promoter to block osteogenesis of bone marrow stromal cells in age-related bone loss of mice
CONCLUSION: HDAC6 accumulation and histone hypoacetylation on Runx2 promoter contributed to the attenuation of in vitro osteogenic differentiation potential of BMSCs from aged mice. Through HDAC6 inhibition, we could activate Runx2 expression and osteogenic differentiation potential of BMSCs from aged mice and alleviate the age-related bone loss of aged mice. Our study will benefit not only for understanding the age-related bone loss, but also for finding new therapies to treat senile osteoporosis.PMID:34454588 | DOI:10.1186/s13287-021-02545-w
Source: Cell Research - August 29, 2021 Category: Cytology Authors: Chao Ma Juan Gao Jun Liang Weixiang Dai Zhenfei Wang Mengjiao Xia Tao Chen Sen Huang Jian Na Long Xu Shiming Feng Kerong Dai Guangwang Liu Source Type: research

Metastasis suppressor 1 controls osteoblast differentiation and bone homeostasis through regulating Src-Wnt/ β-catenin signaling
This study has unraveled that MTSS1 contributes to osteoblast differentiation and bone homeostasis through regulating Src-Wnt/β-catenin signaling. It also suggests the potential of MTSS1 as a new target for the treatment of osteoporosis.PMID:35094173 | DOI:10.1007/s00018-022-04147-y
Source: Cellular and Molecular Life Sciences : CMLS - January 30, 2022 Category: Cytology Authors: Meng Chen Liying Shan Ying Gan Lijie Tian Jie Zhou Endong Zhu Hairui Yuan Xiaoxia Li Baoli Wang Source Type: research

ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NF κB activation
Cell Mol Life Sci. 2022 Feb 26;79(3):155. doi: 10.1007/s00018-022-04186-5.ABSTRACTCellular senescence is closely related to tissue aging including bone. Bone homeostasis is maintained by the tight balance between bone-forming osteoblasts and bone-resorbing osteoclasts, but it undergoes deregulation with age, causing age-associated osteoporosis, a main cause of which is osteoblast dysfunction. Oxidative stress caused by the accumulation of reactive oxygen species (ROS) in bone tissues with aging can accelerate osteoblast senescence and dysfunction. However, the regulatory mechanism that controls the ROS-induced senescence o...
Source: Cellular and Molecular Life Sciences : CMLS - February 26, 2022 Category: Cytology Authors: Hyun-Jung Kim Woo-Jin Kim Hye-Rim Shin Hee-In Yoon Jae-I Moon Eunji Lee Jin-Muk Lim Young-Dan Cho Mi-Hye Lee Hong-Gee Kim Hyun-Mo Ryoo Source Type: research

Downregulation of DNA methyltransferase-3a ameliorates the osteogenic differentiation ability of adipose-derived stem cells in diabetic osteoporosis via Wnt/ β-catenin signaling pathway
CONCLUSIONS: Dnmt3a silencing rescues the negative effects of DOP on ASCs and provides a possible approach for bone tissue regeneration in patients with diabetic osteoporosis.PMID:35927735 | DOI:10.1186/s13287-022-03088-4
Source: Cell Research - August 4, 2022 Category: Cytology Authors: Maorui Zhang Yujin Gao Qing Li Huayue Cao Jianghua Yang Xiaoxiao Cai Jingang Xiao Source Type: research

Methionine Downregulates TLR‐4/MyD88/NF‐κB Signaling in Osteoclasts Precursors to Reduce Bone Loss during Osteoporosis
Conclusions and ImplicationsMethionine prevents OVX induced bone loss by disrupting functional osteoclast development via TLR‐4/MyD88/NF‐κB signaling pathway. Methionine supplementation could be beneficial for treatment against post‐menopausal osteoporosis.
Source: British Journal of Pharmacology - September 30, 2013 Category: Drugs & Pharmacology Authors: V. Vijayan, M. Khandelwal, K. Manglani, S. Gupta, A. Surolia Tags: Research Paper Source Type: research

Active vitamin D possesses beneficial effects on the interaction between muscle and bone.
In conclusion, these findings showed for the first time that active vitamin D plays important roles in myogenesis and muscle-induced osteoblastogenesis through OGN expression. Active vitamin D treatment may rescue the AGEs-induced sarcopenia as well as -suppressed osteoblastic differentiation via OGN expression in myoblasts. PMID: 24924628 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - June 9, 2014 Category: Biochemistry Authors: Tanaka KI, Kanazawa I, Yamaguchi T, Yano S, Kaji H, Sugimoto T Tags: Biochem Biophys Res Commun Source Type: research

IL-6-accelerated calcification by induction of ROR2 in human adipose tissue-derived mesenchymal stem cells is STAT3 dependent
Conclusion. IL-6/sIL-6R stimulation accelerated the ROR2/WNT5A pathway in hADSCs in a STAT3-dependent manner, resulting in augmented calcification. These results suggest that the mechanisms of ectopic calcification accelerated by IL-6 in hADSCs may be involved in chronic inflammatory tissues and that IL-6 inhibitors may be beneficial in the treatment of ectopic calcification in inflammatory diseases.
Source: Rheumatology - June 19, 2014 Category: Rheumatology Authors: Fukuyo, S., Yamaoka, K., Sonomoto, K., Oshita, K., Okada, Y., Saito, K., Yoshida, Y., Kanazawa, T., Minami, Y., Tanaka, Y. Tags: Myositis and Muscle Disease, Vasculitis, Spondylarthropathies, Osteoporosis and Metabolic Bone Disease, Systemic Lupus Erythematosus and Autoimmunity BASIC [AMP ] TRANSLATIONAL SCIENCE Source Type: research

Kirenol stimulates osteoblast differentiation through activation of the BMP and Wnt/β-catenin signaling pathways in MC3T3-E1 cells.
Abstract Kirenol has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities; however, its effect on osteoblast differentiation has not yet been reported. The aim of the present study was to evaluate the effect of kirenol on osteoblast differentiation through activation of the bone morphogenetic protein (BMP) and Wnt/β-catenin signaling pathways in MC3T3-E1 cells. Kirenol markedly promoted alkaline phosphatase (ALP) activity and mineralization. Kirenol not only increased the expression of osteoblast differentiation markers, such as ALP, type I collag...
Source: Fitoterapia - July 23, 2014 Category: Biochemistry Authors: Kim MB, Song Y, Hwang JK Tags: Fitoterapia Source Type: research

Functional analyses reveal the essential role of SOX6 and RUNX2 in the communication of chondrocyte and osteoblast
Conclusions Our study first reveals that SOX6 and RUNX2 play important roles in the chondrogenesis–osteogenesis coordination. This finding enriches the limited understanding about this coordination and unravels the novel function of SOX6 and RUNX2 in the endochondral ossification.
Source: Osteoporosis International - September 12, 2014 Category: Orthopaedics Source Type: research

Anabolic Bone Formation Via a Site Specific Bone Targeting Delivery System by Interfering with Semaphorin 4D Expression
Abstract Recently semaphorins have been targeted as new molecules directly implicated in the cell‐cell communication that occurs between osteoclasts and osteoblasts. Over‐expression of certain semaphorins such as semaphorin4D (sema4D) is found in an osteoporotic phenotype and plays a key role in osteoclast activity by suppressing osteoblast maturation, thus significantly altering the bone modelling cycle. In the present study, we fabricate a site‐specific bone‐targeting drug delivery system from polymeric nanoparticles with the incorporation of siRNA interference molecule for sema4D and demonstrate their cellular u...
Source: Journal of Bone and Mineral Research - August 4, 2014 Category: Orthopaedics Authors: Yufeng Zhang, Lingfei Wei, Richard J. Miron, Bin Shi, Zhuan Bian Tags: Original Article Source Type: research