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Condition: Osteoporosis
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The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation
AbstractOsteoblast differentiation is regulated by various transcription factors, signaling molecules, and posttranslational modifiers. The histone acetyltransferase Mof (Kat8) is involved in distinct physiological processes. However, the exact role of Mof in osteoblast differentiation and growth remains unknown. Herein, we demonstrated that Mof expression with histone H4K16 acetylation increased during osteoblast differentiation. Inhibition of Mof by siRNA knockdown or small molecule inhibitor, MG149 which is a potent histone acetyltransferase inhibitor, reduced the expression level and transactivation potential of osteog...
Source: Cell and Tissue Research - May 29, 2023 Category: Cytology Source Type: research
