Filtered By:
Condition: Osteoporosis
This page shows you your search results in order of relevance. This is page number 8.
Order by Relevance | Date
Total 136 results found since Jan 2013.
Harmine targets inhibitor of DNA binding-2 and activator protein-1 to promote preosteoclast PDGF-BB production
In conclusion, our data demonstrated a novel mechanism involving in the production of PDGF-BB increased by harmine, which may provide potential therapeutic targets for bone loss diseases.PMID:33960660 | DOI:10.1111/jcmm.16562
Source: J Cell Mol Med - May 7, 2021 Category: Molecular Biology Authors: Jie Huang You-You Li Kun Xia Yi-Yi Wang Chun-Yuan Chen Meng-Lu Chen Jia Cao Zheng-Zhao Liu Zhen-Xing Wang Hao Yin Xiong-Ke Hu Zheng-Guang Wang Yong Zhou Hui Xie Source Type: research
Resveratrol induces proliferation in preosteoblast cell MC3T3-E1 via GATA-1 activating autophagy
We examined the cell viability, colony formation, cell cyclin expression, autophagy level, and the expression levels of GATA-1 and adenosine 5'-monophosphate (AMP)-activated protein kinase α (AMPKα) in osteoblastic cell strain MC3T3-E1. The results showed that RSV promoted the proliferation process in MC3T3-E1 coupled with increased expression of GATA-1 and phosphorylated AMPKα and activated autophagy. When GATA-1 was interfered with siRNA, both autophagy and proliferation were decreased. Administration of the agonist of phosphorylated AMPKα1 (Thr172) promoted the translocation of GATA-1 into the nucleus. Based on the ...
Source: Acta Biochimica et Biophysica Sinica - October 12, 2021 Category: Biochemistry Authors: Xiang Liu Jun Tao Yueyi Yao Ping Yang Juhui Wang Mali Yu Jianhong Hou Ying Zhang L I Gui Source Type: research
Phactr1 negatively regulates bone mass by inhibiting osteogenesis and promoting adipogenesis of BMSCs via RhoA/ROCK2
AbstractThe imbalance between osteogenic and adipogenic differentiation of Bone marrow-derived mesenchymal stem cells (BMSCs) is involved in the occurrence and development of osteoporosis (OP). Previous studies have indicated the potential of phosphatase and actin regulator 1 (Phactr1) in regulating osteogenic and adipogenic differentiation of BMSCs. The present study aims to investigate the function and mechanism of Phactr1 in regulating osteogenic and adipogenic differentiation of BMSCs. Herein, the expression of Phactr1 in bone and adipose tissue of OP rats was determined by immunohistochemical. BMSCs were subjected to ...
Source: Journal of Molecular Histology - October 28, 2021 Category: Laboratory Medicine Source Type: research
Notch/NICD/RBP-J signaling axis regulates M1 polarization of macrophages mediated by advanced glycation end products
AbstractAdvanced glycation end products (AGEs) aggregation and macrophages polarization are identified as the main factors contributing to bone diseases caused by aging or diabetes, such as senile or diabetic osteoporosis. Here, we aimed to elucidate the involvement and potential mechanism of AGEs in macrophages polarization and osteoclastogenesis. Firstly, AGEs-treated RAW264.7 macrophages were observed to up-regulate the release of nitric oxide (NO), the expression of M1-associated genes and the surface antigen marker CD86. The detection of osteoclast-related markers and TRAP staining revealed that the osteoclastogenic a...
Source: Glycoconjugate Journal - June 6, 2022 Category: Biochemistry Source Type: research
MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2
Exp Mol Med. 2022 Jul 13. doi: 10.1038/s12276-022-00799-9. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) broadly regulate normal biological functions of bone and the progression of fracture healing and osteoporosis. Recently, it has been reported that miR-1224-5p in fracture plasma is a potential therapy for osteogenesis. To investigate the roles of miR-1224-5p and the Rap1 signaling pathway in fracture healing and osteoporosis development and progression, we used BMMs, BMSCs, and skull osteoblast precursor cells for in vitro osteogenesis and osteoclastogenesis studies. Osteoblastogenesis and osteoclastogenesis were det...
Source: Molecular Medicine - July 13, 2022 Category: Molecular Biology Authors: Liangcong Hu Xudong Xie Hang Xue Tiantian Wang Adriana C Panayi Ze Lin Yuan Xiong Faqi Cao Chengcheng Yan Lang Chen Peng Cheng Kangkang Zha Yun Sun Guodong Liu Chenyan Yu Yiqiang Hu Ranyang Tao Wu Zhou Bobin Mi Guohui Liu Source Type: research
A novel BMP2 secretagogue ameliorates glucocorticoid induced oxidative stress in osteoblasts by activating NRF2 dependent survival while promoting Wnt/ β-catenin mediated osteogenesis
Free Radic Biol Med. 2022 Aug 10:S0891-5849(22)00514-7. doi: 10.1016/j.freeradbiomed.2022.08.007. Online ahead of print.ABSTRACTIn our previous study, a novel BMP2 secretagogue was synthesized belonging to a class of galloyl conjugates of flavanones, with remarkable osteogenic potential that promoted bone regeneration. We aimed to establish the protective effect of our compound against bone loss that co-exists with excess Glucocorticoid (GC) therapy. GC therapy induces osteoblast damage leading to apoptosis by increasing reactive oxygen species (ROS). Our results delineate that compound 5e (a BMP2 secretagogue) activates N...
Source: Free Radical Biology and Medicine - August 13, 2022 Category: Biology Authors: Divya Rai Ashish Kumar Tripathi Anirban Sardar Alka Raj Pandey Shradha Sinha Kunal Chutani Geeta Dhaniya Priyanka Kothari Koneni V Sashidhara Ritu Trivedi Source Type: research
Positive programming of the GC-IGF1 axis mediates adult osteoporosis susceptibility in male offspring rats induced by prenatal dexamethasone exposure
In conclusion, PDE-induced intrauterine hypoglucocorticoid exposure could positively program IGF1 expression in bone tissue through the GRα/miR-130a-5p/HDAC4 pathways, thus mediating osteogenic dysdifferentiation and adult osteoporosis susceptibility in male offspring rats.PMID:36174767 | DOI:10.1016/j.bcp.2022.115264
Source: Biochemical Pharmacology - September 29, 2022 Category: Drugs & Pharmacology Authors: Yangfan Shangguan Xufeng Li Jun Qin Yinxian Wen Hui Wang Liaobin Chen Source Type: research
ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis
CONCLUSION: Osteoblast ferroptosis under HG conditions is induced by ATF3-mediated inhibition of system Xc- activity, and these events contribute to T2DOP pathogenesis.PMID:36340581 | PMC:PMC9629949 | DOI:10.1155/2022/9872243
Source: Disease Markers - November 7, 2022 Category: Laboratory Medicine Authors: Yantao Zhao Yunxia Du Yijie Gao Zhijie Xu Dexiang Zhao Maowei Yang Source Type: research
