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Condition: Rheumatoid Arthritis

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Total 292 results found since Jan 2013.

The induced RNA ‐binding protein, HuR targets 3'‐UTR region of IL‐6 mRNA and enhances its stabilization in periodontitis
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - February 2, 2018 Category: Allergy & Immunology Authors: Kazuhisa Ouhara, Syuichi Munenaga, Mikihito Kajiya, Katsuhiro Takeda, Shinji Matsuda, Yoko Sato, Yuta Hamamoto, Tomoyuki Iwata, Satoshi Yamasaki, Keiichi Akutagawa, Noriyoshi Mizuno, Tsuyoshi Fujita, Eiji Sugiyama, Hidemi Kurihara Tags: Original Article Source Type: research

The induced RNA-binding protein, HuR targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis.
This article is protected by copyright. All rights reserved. PMID: 29393507 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - February 2, 2018 Category: Allergy & Immunology Authors: Ouhara K, Munenaga S, Kajiya M, Takeda K, Matsuda S, Sato Y, Hamamoto Y, Iwata T, Yamasaki S, Akutagawa K, Mizuno N, Fujita T, Sugiyama E, Kurihara H Tags: Clin Exp Immunol Source Type: research

Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts.
CONCLUSIONS: This first report on ARL15 expression in RASF and its likely role in inflammation and metabolic syndromes through a TNF independent pathway, encourages hypothesis-free studies to identify additional pathways underlying RA disease biology. PMID: 29465355 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Hypoxia induces production of citrullinated proteins in human fibroblast ‐like synoviocytes through regulating HIF1α
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Ruohan Yu, Changhong Li, Lin Sun, Leilei Jian, Zhenzhen Ma, Jinxia Zhao, Xiangyuan Liu Tags: Regular Article Source Type: research

The induced RNA ‐binding protein, HuR, targets 3′‐UTR region of IL‐6 mRNA and enhances its stabilization in periodontitis
Summary RNA‐binding proteins (RBPs) regulate mRNA stability by binding to the 3′‐untranslated region (UTR) region of mRNA. Human antigen‐R (HuR), one of the RBPs, is involved in the progression of diseases, such as rheumatoid arthritis, diabetes mellitus and some inflammatory diseases. Interleukin (IL)‐6 is a major inflammatory cytokine regulated by HuR binding to mRNA. Periodontal disease (PD) is also an inflammatory disease caused by elevations in IL‐6 following an infection by periodontopathogenic bacteria. The involvement of HuR in the progression of PD was assessed using in‐vitro and in‐vivo experiment...
Source: Clinical and Experimental Immunology - March 8, 2018 Category: Allergy & Immunology Authors: K. Ouhara, S. Munenaga, M. Kajiya, K. Takeda, S. Matsuda, Y. Sato, Y. Hamamoto, T. Iwata, S. Yamasaki, K. Akutagawa, N. Mizuno, T. Fujita, E. Sugiyama, H. Kurihara Tags: Original Article Source Type: research

Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes.
The objective of this study was to observe the role of miR-10a-5p targeting TBX5 gene on synoviocyte proliferation and apoptosis in RA. Human synovial sarcoma cell line, SW982 cells stimulating with IL-1β were transfected with miR-10a-5p mimic and siRNA of TBX5. The real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting analysis were used to evaluate the expression level of miR-10a-5p and TBX5 in SW982 cells, respectively. Further, the proliferation and apoptosis of SW982 cells after treatment were determined by cell counting kit (CCK-8) and flow cytometry analysis respectively. We found that the ...
Source: Bioscience Reports - March 15, 2018 Category: Biomedical Science Authors: Hussain N, Zhu W, Jiang C, Xu J, Geng M, Wu X, Hussain S, Wang B, Rajoka MSR, Li Y, Tian J, Meng L, Lu S Tags: Biosci Rep Source Type: research

XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B.
Abstract As an endoplasmic reticulum (ER) stress-related protein, mesencephalic astrocyte-derived neurotrophic factor (MANF) is involved in inflammatory diseases, such as rheumatoid arthritis. However, the mechanisms of the transcriptional regulation of MANF is still undefined. Here, we showed that MANF expression was upregulated in hepatitis B tissues and hepatoma cells, and positively correlated with the spliced X-box binding protein-1 (XBP1s). Both overexpression of XBP1s and tunicamycin treatment were able to enhance MANF transcription. On the contrary, inhibition of XBP1 splicing by IRE1α endonuclease inhibi...
Source: The International Journal of Biochemistry and Cell Biology - April 9, 2018 Category: Biochemistry Authors: Wang D, Hou C, Cao Y, Cheng Q, Zhang L, Li H, Feng L, Shen Y Tags: Int J Biochem Cell Biol Source Type: research

Sam68 Promotes Invasion, Migration, and Proliferation of Fibroblast-like Synoviocytes by Enhancing the NF- κB/P65 Pathway in Rheumatoid Arthritis
In this study, we analyzed the effect and possible mechanisms of Sam68 in rheumatoid arthritis (RA). By western blot analysis and immunohistochemistry, we found that the expression of Sam68 in synovial tissue of RA patients was increased compared with the cont rol group. Immunoflourescent staining demonstrated that Sam68 co-localized with fibroblast-like synoviocytes (FLS) of RA patients. Additionally, the expression of Sam68 in FLS was increased by tumor necrosis factor (TNF)-α stimulation, in a time-dependent manner. Upon TNF-α treatment, Sam68 transl ocated from the cytoplasm to the nucleus where it interacted with th...
Source: Inflammation - May 21, 2018 Category: Allergy & Immunology Source Type: research

Interleukin 17 under hypoxia mimetic condition augments osteoclast mediated bone erosion and expression of HIF-1 α and MMP-9.
In conclusion, IL-17 synergizes with CoCl2 induced hypoxic condition to augment osteoclast mediated bone erosion and synovial macrophages mediated RA pathogenesis. PMID: 30029761 [PubMed - as supplied by publisher]
Source: Cellular Immunology - July 17, 2018 Category: Allergy & Immunology Authors: Samarpita S, Doss HM, Ganesan R, Rasool M Tags: Cell Immunol Source Type: research

Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis
The transcription factor NF-kB plays an important role in the pathogenesis of rheumatoid arthritis (RA). Effective treatment of RA is hindered due to the lack of specificity of small molecules in the inflamed ...
Source: Journal of Nanobiotechnology - July 30, 2018 Category: Nanotechnology Authors: Weifeng Duan and Huan Li Tags: Research Source Type: research

Inhibition of C5a prevents IL-1β-induced alternations in rat synoviocytes in vitro
Publication date: Available online 6 August 2018Source: Molecular and Cellular ProbesAuthor(s): Wei Lu, Lin Wang, Jing Yao, Wen Wang, Yu ChenAbstractC5a is an important pro-inflammatory peptide involved in complement activation, membrane attack complex formation, immune cell chemotaxis, and allergic responses. Osteoarthritis is a disease characterized by degenerative changes in articular cartilage. It has recently been found that inflammatory responses play an important role in the pathogenesis of osteoarthritis and also in rheumatoid arthritis, where dysfunctional synoviocytes are involved. We performed a series of studie...
Source: Molecular and Cellular Probes - August 6, 2018 Category: Molecular Biology Source Type: research

Novel Nano therapeutic materials for the effective treatment of Rheumatoid Arthritis- recent insights
Publication date: Available online 15 September 2018Source: Materials Today CommunicationsAuthor(s): Kumar Janakiraman, Venkateshwaran Krishnaswami, Vijaya Rajendran, Subramanian Natesan, Ruckmani KandasamyAbstractRheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destruction, cardiovascular, pulmonary and skeletal disorders. Pro-inflammatory cytokines such as IL-1, IL-6, IL-8,...
Source: Materials Today Communications - September 15, 2018 Category: Materials Science Source Type: research

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights
Publication date: December 2018Source: Materials Today Communications, Volume 17Author(s): Kumar Janakiraman, Venkateshwaran Krishnaswami, Vijaya Rajendran, Subramanian Natesan, Ruckmani KandasamyAbstractRheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destruction, cardiovascular, pulmonary and skeletal disorders. Pro-inflammatory cytokines such as IL-1, IL-6, IL-8, and IL-10...
Source: Materials Today Communications - October 4, 2018 Category: Materials Science Source Type: research

Sam68 Promotes Invasion, Migration, and Proliferation of Fibroblast-like Synoviocytes by Enhancing the NF- κB/P65 Pathway in Rheumatoid Arthritis
In this study, we analyzed the effect and possible mechanisms of Sam68 in rheumatoid arthritis (RA). By western blot analysis and immunohistochemistry, we found that the expression of Sam68 in synovial tissue of RA patients was increased compared with the cont rol group. Immunoflourescent staining demonstrated that Sam68 co-localized with fibroblast-like synoviocytes (FLS) of RA patients. Additionally, the expression of Sam68 in FLS was increased by tumor necrosis factor (TNF)-α stimulation, in a time-dependent manner. Upon TNF-α treatment, Sam68 transl ocated from the cytoplasm to the nucleus where it interacted with th...
Source: Inflammation - October 1, 2018 Category: Allergy & Immunology Source Type: research

Reciprocal regulation of pro-inflammatory Annexin A2 and anti-inflammatory Annexin A1 in the pathogenesis of rheumatoid arthritis.
Abstract Annexin A2 has been implicated in several immune modulated diseases including Rheumatoid arthritis (RA) pannus formation. The most relied treatment option for RA pathogenesis is glucocorticoids. Glucocorticoids regulate the synthesis, phosphorylation and cellular deposition of Annexin A1. This annexin mediates the anti-inflammatory actions of glucocorticoids. These two first characterized members of annexin superfamily proteins acts reciprocally, one as an anti-inflammatory and the other proinflammatory in nature. The possibility of these molecules as soluble biomarkers and as an upstream regulator of maj...
Source: Molecular Biology Reports - November 13, 2018 Category: Molecular Biology Authors: Haridas V, Shetty P, Sarathkumar E, Bargale A, Vishwanatha JK, Patil V, Dinesh US Tags: Mol Biol Rep Source Type: research