Interleukin 17 under hypoxia mimetic condition augments osteoclast mediated bone erosion and expression of HIF-1 α and MMP-9.

In conclusion, IL-17 synergizes with CoCl2 induced hypoxic condition to augment osteoclast mediated bone erosion and synovial macrophages mediated RA pathogenesis. PMID: 30029761 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30029761?dopt=Abstract

Source: Cellular Immunology - July 17, 2018 Category: Allergy & Immunology Authors: Samarpita S, Doss HM, Ganesan R, Rasool M Tags: Cell Immunol Source Type: research