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Condition: Psoriasis
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Total 103 results found since Jan 2013.
Targeting upregulation of the immunosuppressive activity of MDSCs with indirubin as a novel strategy to alleviate psoriasis
CONCLUSION: This study demonstrates indirubin's pharmacological and therapeutic effects, providing a basis for future clinical application in treating psoriasis.PMID:37531829 | DOI:10.1016/j.intimp.2023.110710
Source: International Immunopharmacology - August 2, 2023 Category: Allergy & Immunology Authors: Yifei Hou Huimin Zhang Yangzhuangzhuang Zhu Xufeng He Wen Li Lin Su Mingxi Liu Xi Chen Fang Shen Xiao Chen Wencheng Jiang Chunpu Zou Zihang Xu Source Type: research
TNF- α promotes CXCL-1/8 production in keratinocytes by downregulating galectin-3 through NF-κB and hsa-miR-27a-3p pathway to contribute psoriasis development
CONCLUSION: TNF-α initiates psoriatic inflammation by increasing CXCL-1/8 in keratinocytes mediated by the axis of NF-κB-hsa-miR-27a-3p-galectin-3 pathway.PMID:37358143 | DOI:10.1080/08923973.2023.2229510
Source: Immunopharmacology and Immunotoxicology - June 26, 2023 Category: Allergy & Immunology Authors: Xiao-Nan Qiu Dan Hong Zhen-Rui Shi Si-Yao Lu Yu-Xian Lai Yan-Ling Ren Xiu-Ting Liu Chi-Peng Guo Guo-Zhen Tan Liang-Chun Wang Source Type: research
Protein Kinase CK2 Promotes Proliferation, Abnormal Differentiation, and Proinflammatory Cytokine Production of Keratinocytes via Regulation of STAT3 and Akt Pathways in Psoriasis
Am J Pathol. 2023 May;193(5):567-578. doi: 10.1016/j.ajpath.2023.01.016.ABSTRACTProtein kinase CK2 is a constitutively active and ubiquitously expressed serine/threonine kinase that is closely associated with various types of cancers, autoimmune disorders, and inflammation. However, the role of CK2 in psoriasis remains unknown. Herein, the study indicated elevated expression of CK2 in skin lesions from patients with psoriasis and from psoriasis-like mice. In the psoriasis-like mouse model, the CK2-specific inhibitor CX-4945 ameliorated imiquimod-induced psoriasis symptoms with reduced proliferation, abnormal differentiatio...
Source: Am J Pathol - April 25, 2023 Category: Pathology Authors: Wenjie Huang Xuyu Zheng Qi Huang Danlin Weng Shifei Yao Cui Zhou Qian Li Yulian Hu Wenchun Xu Kun Huang Source Type: research
Suprabasin-derived polypeptides: SBSN(50-63) induces inflammatory response via TLR4-mediated mast cell activation
This study was conducted to clarify whether SBSN(50-63) plays a pivotal role in activating mast cells and mediating proinflammatory cytokines and chemokines production in psoriasis. The increased expression of SBSN in psoriatic lesions was confirmed by bioinformatics analysis, PCR and ELISA. Wild-type mice injected subcutaneously with SBSN(50-63) exhibited infiltration of inflammatory cells and the release of cytokines in vivo. SBSN(50-63) stimulated mouse primary mast cells (MPMC) and the laboratory of allergic disease 2 (LAD2) human mast cells to produce more inflammatory mediators than the control group, which were meas...
Source: Inflammopharmacology - February 6, 2023 Category: Drugs & Pharmacology Source Type: research
Inhibition of serum and glucocorticoid-regulated protein kinase-1 aggravates imiquimod-induced psoriatic dermatitis and enhances proinflammatory cytokine expression via the NF-kappaB pathway
In this study, we found that SGK1 expression was decreased in macrophages from psoriasis patients. Moreover, a specific pharmacological SGK1 inhibitor, EMD638683, significantly enhanced imiquimod (IMQ)-mediated TLR7/8 activity and proinflammatory cytokine production in RAW264.7 cells, and this result was confirmed by SGK1 siRNA.
Source: Journal of Investigative Dermatology - January 5, 2023 Category: Dermatology Authors: Qinqin Meng, Mei Bai, Meiliang Guo, Zhengxiao Li, Wanwen Liu, Xiaojing Fan, Rui Sun, Xinrong Yang, Dingfen Yuan, Yuling Shi, Hui Deng Tags: Original Article Source Type: research
Neuroblast Differentiation-Associated Protein Derived Polypeptides: AHNAK(5758-5775) Induces Inflammation by Activating Mast Cells via ST2
This study aimed to investigate whether AHNAK (5758-5775), a neuroblast differentiation-associated protein-derived polypeptide, could be considered a new endogenous substance in psoriasis patients, which activates mast cells and induces the skin inflammatory response contributing to psoriasis. Wild-type mice were treated with AHNAK(5758-5775) to observe the infiltration of inflammatory cells in the skin and cytokine release in vivo. The release of inflammatory mediators by mouse primary mast cells and the laboratory of allergic disease 2 (LAD2) human mast cells was measured in vitro. Molecular docking analysis, molecular d...
Source: Immunological Investigations - December 13, 2022 Category: Allergy & Immunology Authors: Xiangjin Song Lei Zhang Xueshan Du Yi Zheng Tao Jia Tong Zhou Delu Che Songmei Geng Source Type: research
374 Eukaryotic translation initiation factor 4E (eIF4E) as a target of anti-psoriatic treatment
Eukaryotic translation initiation factor 4E (eIF4E) has been known to play a critical role in the regulation of gene expression in eukaryotes and to affect many essential cellular processes, including proliferation, apoptosis and differentiation. We and others found eIF4E and other eIF subunits upregulated in human psoriatic skin and thus hypothesized that they are involved in the pathophysiology of psoriasis and can serve as direct topical targets for anti-psoriatic treatment. We used specific eIF4E siRNA or briciclib an eIF4E inhibitor in HaCaT cells, a human 3D-psoriasis tissue model as well as the imiquimod and TGF ß ...
Source: Journal of Investigative Dermatology - November 18, 2022 Category: Dermatology Authors: N. Golob-Schwarzl, J. Pilic, T. Benezeder, N. Bordag, C. Painsi, P. Wolf Source Type: research
GSE216519 Effect of depletion of AIM2 on gene expression in psoriatic NETs-treated primary human keratinocytes
Contributors : Xu Yuan ; Tianyu Cao ; Shuai ShaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of the NET-AIM2 axis on keratinocyte activation during psoriasis, we established psoriatic NETs-treated primary human keratinocytes in which AIM2 has been knocked down by siRNA
Source: GEO: Gene Expression Omnibus - October 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
