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Condition: Psoriasis

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Total 103 results found since Jan 2013.

IL ‐17F regulates psoriasis‐associated genes through IκBζ
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - August 29, 2016 Category: Dermatology Authors: Trine Bertelsen, Christine Ljungberg, Rasmus Boye Kjellerup, Lars Iversen, Claus Johansen Tags: Regular Article Source Type: research

USP2 as a potential link between miR-125b and psoriasis.
CONCLUSIONS: Shedding further light on the multi-factorial causes of psoriasis is essential, if the goal is to progress towards finer control of therapeutic tools in disease management. Findings, such as the ones presented herein, are therefore necessary in order to achieve the future of personalized medicine. This article is protected by copyright. All rights reserved. PMID: 27479112 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - July 31, 2016 Category: Dermatology Authors: Wei T, Folkersen L, Biskup E, Xu N, Manfe V, Niazi O, Gniadecki R Tags: Br J Dermatol Source Type: research

USP2 as a potential link between miR ‐125b and psoriasis
ConclusionsShedding further light on the multi‐factorial causes of psoriasis is essential, if the goal is to progress towards finer control of therapeutic tools in disease management. Findings, such as the ones presented herein, are therefore necessary in order to achieve the future of personalized medicine.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - July 31, 2016 Category: Dermatology Authors: T. Wei, L. Folkersen, E. Biskup, N. Xu, V. Manfe, O. Niazi, R. Gniadecki Tags: Original Article Source Type: research

PGRN Suppresses Inflammation and Promotes Autophagy in Keratinocytes Through the Wnt/ β-Catenin Signaling Pathway
Abstract Psoriasis is a chronic, immune-mediated inflammatory skin disease that has a major impact on patients ’ quality of life. Progranulin (PGRN) is highly expressed in skin diseases and plays an important role in inflammation response and autophagy. However, the function of PGRN in the immune system and autophagy in psoriasis has not been clearly identified and elaborated on. Thus, this study aimed to investigate the role of PGRN on the inflammatory and autophagy process underlying inflammation in HaCaT cells. We showed that PGRN was markedly highly expressed in psoriasis lesions and inflammatory HaCaT cells. Specif...
Source: Inflammation - July 21, 2016 Category: Allergy & Immunology Source Type: research

PGRN Suppresses Inflammation and Promotes Autophagy in Keratinocytes Through the Wnt/β-Catenin Signaling Pathway
Abstract Psoriasis is a chronic, immune-mediated inflammatory skin disease that has a major impact on patients’ quality of life. Progranulin (PGRN) is highly expressed in skin diseases and plays an important role in inflammation response and autophagy. However, the function of PGRN in the immune system and autophagy in psoriasis has not been clearly identified and elaborated on. Thus, this study aimed to investigate the role of PGRN on the inflammatory and autophagy process underlying inflammation in HaCaT cells. We showed that PGRN was markedly highly expressed in psoriasis lesions and inflammatory HaCaT cells...
Source: Inflammation - July 20, 2016 Category: Allergy & Immunology Source Type: research

Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol
ConclusionsCalcipotriol exhibits its antipsoriatic function through suppressing A20 expression and stabilizing negative regulators of the NF‐κB pathway.
Source: British Journal of Dermatology - May 13, 2016 Category: Dermatology Authors: X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng, Y. Xia Tags: Translational Research Source Type: research

Psoriasin (S100A7) promotes stress‐induced angiogenesis
ConclusionThese findings suggest that psoriasin expression is promoted by oxidative stress in keratinocytes and amplifies the ROS‐induced expression of angiogenic factors relevant to psoriasis. Moreover, extracellularly secreted psoriasin may act on dermal endothelial cells to contribute to key features of the angiogenic process.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - May 6, 2016 Category: Dermatology Authors: J. Vegfors, A.‐K. Ekman, S.W. Stoll, C. Bivik Eding, C. Enerbäck Tags: Original Article Source Type: research

Psoriasin (S100A7) promotes stress-induced angiogenesis.
CONCLUSION: These findings suggest that psoriasin expression is promoted by oxidative stress in keratinocytes and amplifies the ROS-induced expression of angiogenic factors relevant to psoriasis. Moreover, extracellularly secreted psoriasin may act on dermal endothelial cells to contribute to key features of the angiogenic process. This article is protected by copyright. All rights reserved. PMID: 27155199 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - May 6, 2016 Category: Dermatology Authors: Vegfors J, Ekman AK, Stoll SW, Bivik Eding C, Enerbäck C Tags: Br J Dermatol Source Type: research

Treating psoriasis by targeting its susceptibility gene Rel.
Abstract Psoriasis is a chronic inflammatory disorder of the skin. Accumulating evidence indicates that the Rel gene, a member of the NF-κB family, is a risk factor for the disease. We sought to investigate whether psoriasis can be prevented by directly targeting the Rel gene transcript, i.e., the c-Rel mRNA. Using chemically-modified c-Rel specific siRNA (siRel) and poly(ethylene glycol)-b-poly(l-lysine)-b-poly(l-leucine) (PEG-PLL-PLLeu) micelles, we successfully knocked down the expression of c-Rel, and showed that the expression of cytokine IL-23, a direct target of c-Rel that can drive the development of IL-1...
Source: Clinical Immunology - March 15, 2016 Category: Allergy & Immunology Authors: Fan T, Wang S, Yu L, Yi H, Liu R, Geng W, Wan X, Ma Y, Cai L, Chen YH, Ruan Q Tags: Clin Immunol Source Type: research

Methotrexate and its therapeutic antagonists, caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1).
This article is protected by copyright. All rights reserved. PMID: 26909742 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - February 23, 2016 Category: Allergy & Immunology Authors: Talme T, Bergdahl E, Sundqvist KG Tags: Eur J Immunol Source Type: research

Zinc finger protein A20 is involved in the anti‐psoriatic effect of calcipotriol
ConclusionsCalcipotriol exhibits anti‐psoriatic function through suppressing A20 expression and stabilizing negative regulators of NF‐κB pathway.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - February 15, 2016 Category: Dermatology Authors: X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng, Y. Xia Tags: Original Article Source Type: research

Zinc finger protein A20 is involved in the anti-psoriatic effect of calcipotriol.
CONCLUSIONS: Calcipotriol exhibits anti-psoriatic function through suppressing A20 expression and stabilizing negative regulators of NF-κB pathway. This article is protected by copyright. All rights reserved. PMID: 26875609 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - February 15, 2016 Category: Dermatology Authors: Liu X, Liu Y, Xu M, Li J, Teng X, Cheng H, Xia Y Tags: Br J Dermatol Source Type: research

An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: Proof-of-concept in the treatment of psoriasis
Publication date: 16 March 2016 Source:International Journal of Pharmaceutics, Volume 500, Issues 1–2 Author(s): Eline Desmet, Stefanie Bracke, Katrien Forier, Lien Taevernier, Marc C.A. Stuart, Bart De Spiegeleer, Koen Raemdonck, Mireille Van Gele, Jo Lambert RNA interference (RNAi) is a rapidly emerging approach for targeted gene silencing to alleviate disease pathology. However, lack of efficient carriers for targeted delivery delays the clinical translation of RNAi. An interesting target for local RNAi therapeutics is the skin as it allows direct access to target cells. Still, applications are limited due ...
Source: International Journal of Pharmaceutics - January 31, 2016 Category: Drugs & Pharmacology Source Type: research

MiR-217 is down-regulated in psoriasis and promotes keratinocyte differentiation via targeting GRHL2.
In this study, we found the expression of miR-217 was markedly down-regulated in psoriasis keratinocytes of psoriatic patients. In addition, overexpression of miR-217 inhibited the proliferation and promoted the differentiation of primary human keratinocytes. On the contrary, inhibition of endogenous miR-217 increased cell proliferation and delayed differentiation. Furthermore, Grainyhead-like 2 (GRHL2) was identified as a direct target of miR-217 by luciferase reporter assay. The expression of miR-217 and GRHL2 was inversely correlated in both transfected keratinocytes and in psoriasis lesional skin. Moreover, knocking do...
Source: Biochemical and Biophysical Research communications - January 27, 2016 Category: Biochemistry Authors: Zhu H, Hou L, Liu J, Li Z Tags: Biochem Biophys Res Commun Source Type: research

Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4+ T Helper Cells
Conclusions: Inhibiting Gβγ to produce these shifts in cytokine mRNA production might be beneficial for patients with autoimmune diseases such as rheumatoid arthritis (RA), Crohn’s disease (CD), psoriasis, multiple sclerosis (MS), and Hashimoto’s thyroiditis (HT), in which both IFN-γ and IL-17A are elevated. Published on None
Source: Journal of Molecular Signaling - August 21, 2015 Category: Molecular Biology Source Type: research