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Condition: Crohn's Disease

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Total 54 results found since Jan 2013.

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters
Conclusion In summary, this study is the first to combine metabolomics, transcriptomics, and genome-wide association studies in a porcine model. Our results improve understanding of the genetic regulation of metabolites which link to transcripts and finally biochemical-clinical parameters. Further, high-performance profiling of metabolites as intermediate phenotypes is a potentially powerful approach to uncover how genetic variation affects metabolic and health status. Our results advance knowledge in areas of biomedical and agricultural interest and identify potential correlates of biomarkers, SNPs-metabolites, SNPs-tran...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR ‑16‑1/HSP70 pathway.
Triptolide inhibits migration and proliferation of fibroblasts from ileocolonic anastomosis of patients with Crohn's disease via regulating the miR‑16‑1/HSP70 pathway. Mol Med Rep. 2019 Apr 03;: Authors: Chen M, Wang JM, Wang D, Wu R, Hou HW Abstract Anastomotic fibrosis is highly likely to lead to reoperation in Crohn's disease (CD) patients. Triptolide (TPL) is considered to have anti‑inflammatory and antifibrotic effects in a variety of autoimmune diseases, including CD. The present study aimed to investigate the effects of TPL on fibroblasts from strictured ileocolonic anastomosis of patients...
Source: Molecular Medicine Reports - April 5, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Expression of human REG family genes in inflammatory bowel disease and their molecular mechanism
AbstractThe pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn ’s disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. However, expression of all theREG family genes in IBD is still unclear. Here, we analyzed expression of all theREG family genes (REGI α,REGI β,REG III,HIP/PAP, andREG IV) in biopsy specimens of UC and CD by real-time RT-PCR.REG I α,REG I β, andREG IV genes were overexpressed in CD samples.REG IV ge...
Source: Immunologic Research - January 29, 2019 Category: Allergy & Immunology Source Type: research

Transforming growth factor β1-induced collagen production in myofibroblasts is mediated by reactive oxygen species derived from NADPH oxidase 4.
In this study, we examined the role of NOX4 in collagen production by intestinal myofibroblasts stimulated with transforming growth factor (TGF)-β1. Using LmcMF cells, an intestinal subepithelial myofibroblast (ISEMF) line, we first examined the induction of collagen production by TGF-β1. Subsequently, we investigated the role of NOX4 in TGF-β1-induced collagen I production in these cells using SB525334 (an SMAD2/3 inhibitor), diphenyleneiodonium (an NOX inhibitor), and Nox4 small interfering RNA (siRNA). Production of collagen was assessed with Sirius red staining, and Nox4 expression was measured by quantitative real-...
Source: Biochemical and Biophysical Research communications - October 23, 2018 Category: Biochemistry Authors: Hotta Y, Uchiyama K, Takagi T, Kashiwagi S, Nakano T, Mukai R, Toyokawa Y, Yasuda T, Ueda T, Suyama Y, Murakami T, Tanaka M, Majima A, Doi T, Hirai Y, Mizushima K, Morita M, Higashimura Y, Inoue K, Fukui A, Okayama T, Katada K, Kamada K, Handa O, Ishikawa Tags: Biochem Biophys Res Commun Source Type: research

Expression of Human Cathelicidin Peptide LL-37 in Inflammatory Bowel Disease.
This article is protected by copyright. All rights reserved. PMID: 28872665 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - September 5, 2017 Category: Allergy & Immunology Authors: Kusaka S, Nishida A, Takahashi K, Bamba S, Yasui H, Kawahara M, Inatomi O, Sugimoto M, Andoh A Tags: Clin Exp Immunol Source Type: research

Expression of Human Cathelicidin Peptide LL ‐37 in Inflammatory Bowel Disease
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - September 1, 2017 Category: Allergy & Immunology Authors: Shoko Kusaka, Atsushi Nishida, Kenichiro Takahashi, Shigeki Bamba, Hiroyuki Yasui, Masahiro Kawahara, Osamu Inatomi, Mitsushige Sugimoto, Akira Andoh Tags: Original Article Source Type: research

Chromosome region maintenance-1 (CRM1) regulates apoptosis of intestinal epithelial cells via p27kip1 in Crohn's disease
Conclusions Up-regulated CRM1 may facilitate IEC apoptosis possibly through p27kip1 in CD, indicating an important role of CRM1 in the pathophysiology of CD.
Source: Clinics and Research in Hepatology and Gastroenterology - March 9, 2017 Category: Gastroenterology Source Type: research

Microtubule-associated protein 1S-related autophagy inhibits apoptosis of intestinal epithelial cells via Wnt/ β-catenin signaling in Crohn's disease.
Microtubule-associated protein 1S-related autophagy inhibits apoptosis of intestinal epithelial cells via Wnt/β-catenin signaling in Crohn's disease. Biochem Biophys Res Commun. 2017 Feb 07;: Authors: Bai W, Bai J, Li Y, Tian D, Shi R Abstract Many autophagy-related genes, to our knowledge, have been identified as Crohn's disease (CD) polymorphic sites by genomic wide studies. As a novel member of the microtubule-associated protein 1 (MAP1) family, MAP1S is a microtubule-binding proteins involved in autophagy. However, its expression and potential functions in CD have not been understood. For the fir...
Source: Biochemical and Biophysical Research communications - February 6, 2017 Category: Biochemistry Authors: Bai W, Bai J, Li Y, Tian D, Shi R Tags: Biochem Biophys Res Commun Source Type: research

Differential effects of {alpha}4{beta}7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo
Conclusions α4β7 rather than GPR15 is crucial for increased colonic homing of UC Treg cells in vivo, while both receptors control UC Teff cell homing. Vedolizumab treatment impairs homing of UC Treg cells leading to their accumulation in peripheral blood with subsequent suppression of systemic Teff cell expansion.
Source: Gut - September 7, 2016 Category: Gastroenterology Authors: Fischer, A., Zundler, S., Atreya, R., Rath, T., Voskens, C., Hirschmann, S., Lopez-Posadas, R., Watson, A., Becker, C., Schuler, G., Neufert, C., Atreya, I., Neurath, M. F. Tags: Open access Inflammatory bowel disease Source Type: research

The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction
Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have previously shown that the apical addition of serine proteases to intestinal epithelial cell lines causes a rapid and sustained increase in transepithelial electrical resistance (TER), but the mechanisms are unknown. We hypothesized that serine proteases increase barrier function through trafficking and insertion of tight junction proteins into the membrane, and this could enhan...
Source: AJP: Gastrointestinal and Liver Physiology - August 31, 2016 Category: Gastroenterology Authors: Ronaghan, N. J., Shang, J., Iablokov, V., Zaheer, R., Colarusso, P., Turner, J. R., MacNaughton, W. K. Tags: EPITHELIAL BIOLOGY AND SECRETION Source Type: research

The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.
Abstract Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have previously shown that the apical addition of serine proteases to intestinal epithelial cell lines causes a rapid and sustained increase in transepithelial electrical resistance (TER), but the mechanisms are unknown. We hypothesized that serine proteases increase barrier function through trafficking and insertion of tight junction proteins into the membrane, an...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - August 3, 2016 Category: Physiology Authors: Ronaghan NJ, Shang J, Iablokov V, Zaheer R, Colarusso P, Turner JR, MacNaughton WK Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

GSE69445 Crohn's disease risk variant in GPR65 alters lysosomal function
Contributors : K Lassen ; G Goel ; R J XavierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUsing an siRNA screen we identify a role for GPR65 in the defense against intracellular pathogens. Epithelial cells and macrophages lacking GPR65 exhibited impaired clearance of intracellular bacteria as well as an accumulation of aberrant phagosomes and lysosomes. Transcriptional profiling revealed changes in genes associated with lysosomal function.
Source: GEO: Gene Expression Omnibus - June 15, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's Disease.
This study was designed to investigate whether SOCS1 has a role in the death of intestinal epithelial cells and intestinal injury. The results showed that the expression of SOCS1 increased in CD patients, and the expression of SOCS1, p-p53 and PUMA increased in mouse TNBS induced colitis model. Using IFN-γ treated HT-29 cells as an apoptotic model of intestinal epithelial cells in vitro, we confirmed that SOCS1 promoted apoptosis of intestinal epithelial cells by activating p53. In HT-29 cells which were treated with IFN-γ, the interaction between p53 and SOCS1 and phosphorylation of p53 was significantly higher than unt...
Source: Experimental and Molecular Pathology - May 24, 2016 Category: Pathology Authors: Cui X, Shan X, Qian J, Ji Q, Wang L, Wang X, Li M, Ding H, Liu Q, Chen L, Zhang D, Ni R Tags: Exp Mol Pathol Source Type: research

Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn's disease and smooth muscle hypertrophy
The igf1 gene is alternatively spliced as IGF-IEa and IGF-IEc variants in humans. In fibrostenotic Crohn's disease, the fibrogenic cytokine TGF-β1 induces IGF-IEa expression and IGF-I production in intestinal smooth muscle and results in muscle hyperplasia and collagen I production that contribute to stricture formation. Mechano-growth factor (MGF) derived from IGF-IEc induces skeletal and cardiac muscle hypertrophy following stress. We hypothesized that increased IGF-IEc expression and MGF production mediated smooth muscle hypertrophy also characteristic of fibrostenotic Crohn's disease. IGF-IEc transcripts and MGF p...
Source: AJP: Gastrointestinal and Liver Physiology - December 1, 2015 Category: Gastroenterology Authors: Li, C., Vu, K., Hazelgrove, K., Kuemmerle, J. F. Tags: HORMONES, NEUROTRANSMITTERS, GROWTH FACTORS, RECEPTORS, AND SIGNALING Source Type: research