Differential effects of {alpha}4{beta}7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

Conclusions
α4β7 rather than GPR15 is crucial for increased colonic homing of UC Treg cells in vivo, while both receptors control UC Teff cell homing. Vedolizumab treatment impairs homing of UC Treg cells leading to their accumulation in peripheral blood with subsequent suppression of systemic Teff cell expansion.

Source: Gut - September 7, 2016 Category: Gastroenterology Authors: Fischer, A., Zundler, S., Atreya, R., Rath, T., Voskens, C., Hirschmann, S., Lopez-Posadas, R., Watson, A., Becker, C., Schuler, G., Neufert, C., Atreya, I., Neurath, M. F. Tags: Open access Inflammatory bowel disease Source Type: research