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Condition: Nephritis

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Total 28 results found since Jan 2013.

Dysregulation of PTEN caused by the underexpression of microRNA ‑130b is associated with the severity of lupus nephritis.
Dysregulation of PTEN caused by the underexpression of microRNA‑130b is associated with the severity of lupus nephritis. Mol Med Rep. 2018 Apr 03;: Authors: Wu S, Wang J, Li F Abstract There are several reports in the literature regarding microRNA (miR)‑130b. It has been reported that miR‑130b is involved in several diseases. The present study aimed to understand the association between the levels of miR‑130b and lupus nephritis in patients. A total of 61 blood samples were collected and the expression level of miR‑130b was determined. The online miRNA database was then searched using the 'se...
Source: Molecular Medicine Reports - April 6, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis.
In conclusion, DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage, which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1 nephritis. PMID: 29568121 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Immunology - March 22, 2018 Category: Molecular Biology Authors: Lu Y, Mei Y, Chen L, Wu L, Wang X, Zhang Y, Fu B, Chen X, Xie Y, Cai G, Bai X, Li Q, Chen X Tags: Cell Mol Immunol Source Type: research

The novel involvement of podocyte autophagic activity in the pathogenesis of lupus nephritis.
CONCLUSIONS: This study demonstrates that autophagic activity of podocytes is a crucial factor in renal injury by directly affecting the function of podocyte; thus, inhibiting this activity during the early stages of LN is implicated as a potential therapeutic strategy for delaying the progression of LN. Also, clinical application in LN needs to consider patients' pathological type and drugs' comprehensive effectiveness. PMID: 29446059 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - February 17, 2018 Category: Cytology Tags: Histol Histopathol Source Type: research

Rapamycin reverses the senescent phenotype and improves immunoregulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway.
Abstract We have shown that bone marrow (BM)-derived mesenchymal stem cells (BM-MSCs) from SLE patients exhibit senescent behavior and are involved in the pathogenesis of SLE. The aim of this study was to investigate the effects of rapamycin (RAPA) on the senescences and immunoregulatory ability of MSCs of MRL/lpr mice and SLE patients and the underlying mechanisms. Cell morphology, senescence associated β-galactosidase (SA-β-gal) staining, F-actin staining were used to detect the senescence of cells. BM-MSCs and purified CD4+ T cells were co-cultured indirectly. Flow cytometry was used to inspect the proportion...
Source: Aging - April 1, 2016 Category: Biomedical Science Authors: Gu Z, Tan W, Ji J, Feng G, Meng Y, Da Z, Guo G, Xia Y, Zhu X, Shi G, Cheng C Tags: Aging (Albany NY) Source Type: research

Lupus nephritis IgG induces the expression of calcium/calmodulin‐dependent kinase type IV in podocytes and alters their function
Conclusions: LN IgG enters podocytes and upregulates CaMKIV followed by increased expression of genes known to be linked to podocyte damage and T cell activation. Targeted inhibition of CaMKIV in podocytes may prove of clinical use in patients with LN. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 4, 2015 Category: Rheumatology Authors: Kunihiro Ichinose, Takeshi Ushigusa, Ayako Nishino, Yosikazu Nakashima, Takahisa Suzuki, Yoshiro Horai, Tomohiro Koga, Shin‐ya Kawashiri, Naoki Iwamoto, Mami Tamai, Kazuhiko Arima, Hideki Nakamura, Yoko Obata, Kazuo Yamamoto, Tomoki Origuchi, Tomoya Nis Tags: Full Length Source Type: research

Lupus Nephritis: Glycogen Synthase Kinase 3β Promotion of Renal Damage Through Activation of the NLRP3 Inflammasome in Lupus‐Prone Mice
ConclusionThese results show that GSK‐3β promotes lupus nephritis at least partly by activating the NLRP3/IL‐1β pathway. The linking of GSK‐3β to the NLRP3/IL‐1β pathway is a novel observation in our study. Our results suggest that the GSK‐3β/NLRP3/IL‐1β pathway may be a potential therapeutic target for lupus in humans.
Source: Arthritis and Rheumatism - March 27, 2015 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Yuefang Huang, Hui Zhang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Systemic Lupus Erythematosus Source Type: research

Lupus nephritis: Glycogen synthase kinase 3β promotes renal damage through activation of NLRP3 inflammasome in lupus‐prone mice
Conclusion. These results show that GSK3β promotes LN, at least in part, by activating the NLRP3/IL‐1β pathway. The linking of GSK3β to the NLRP3/IL‐1β pathway is a novel observation in our study. Our results suggest that the GSK3β/NLRP3/IL‐1β pathway may be potential therapeutic targets for human lupus. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 15, 2014 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Yuefang Huang, Hui Zhang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Full Length Source Type: research

The PTEN/PI3K/Akt signaling pathway mediates HMGB1-induced cell proliferation by regulating the NF-{kappa}B/cyclin D1 pathway in mouse mesangial cells
Our previous experiment confirmed that high-mobility group box chromosomal protein 1 (HMGB1) was involved in the pathogenesis of Lupus nephritis (LN) by upregulating the proliferation of the mouse mesangial cell line (MMC) through the cyclin D1/CDK4/p16 system, but the precise mechanism is still unknown. Therefore, in the present study, we demonstrated that HMGB1 induced the proliferation of MMC cells in a time- and concentration-dependent manner, downregulated phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression, increased the level of Akt serine 473 phosphorylation, and induced p65 subunit nuclear t...
Source: AJP: Cell Physiology - June 15, 2014 Category: Cytology Authors: Feng, X.-J., Liu, S.-X., Wu, C., Kang, P.-P., Liu, Q.-J., Hao, J., Li, H.-B., Li, F., Zhang, Y.-J., Fu, X.-H., Zhang, S.-B., Zuo, L.-F. Tags: CALL FOR PAPERS Source Type: research

Experimental acute kidney injury
Conclusions: WNT10A expression may promote fibrotic progression and kidney dysfunction in AIN. Blockade of WNT10A expression may be a feasible therapeutic strategy against kidney fibrosis.
Source: Nephrology Dialysis Transplantation - May 21, 2014 Category: Urology & Nephrology Authors: Kuma, A., Yamada, S., Miyamoto, T., Serino, R., Tamura, M., Otsuji, Y., Kohno, K., Cho, W. Y., Kim, M.-G., Jo, S.-K., Kim, H. K., Jado, J. C., Humanes, B., Lopez-Parra, V., Camano, S., Lara, J. M., Cercenado, E., Tejedor, A., Lazaro, A., Jansen, M., Caste Tags: Sunday, June 1st, 2014: Posters Source Type: research

The PTEN/PI3K/Akt signalling pathway mediates HMGB1-induced cell proliferation by regulating the NF-κB/cyclin D1 pathway in mouse mesangial cells.
Abstract Our previous experiment confirmed that high mobility group box chromosomal protein 1 ( HMGB1 ) was involved in the pathogenesis of Lupus nephritis ( LN ) by up-regulating the proliferation of mouse mesangial cells ( MMC ) through the cyclin D1/CDK4/p16 system, but the precise mechanism is still unknown. Thereforein the present study, we demonstrated that HMGB1 induced the proliferation of MMC in time- and concentration-dependent manner, down-regulated phosphatase and tensin homolog deleted on chromosome ten ( PTEN ) expression, increased the level of Akt serine 473 phosphorylation, and induced p65 subunit...
Source: American Journal of Physiology. Cell Physiology - April 23, 2014 Category: Cytology Authors: Feng XJ, Liu SX, Wu C, Kang PP, Liu Q, Hao J, Li HB, Li F, Zhang Y, Fu XH, Zhang SB, Zuo LF Tags: Am J Physiol Cell Physiol Source Type: research

P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway
ConclusionActivation of the P2X7 signaling pathway accelerates murine LN by activating the NLRP3/ASC/caspase 1 inflammasome, resulting in increased IL‐1β production and enhanced Th17 cell polarization. Thus, targeting of the P2X7/NLRP3 pathway should be considered as a novel therapeutic strategy in patients with lupus.
Source: Arthritis and Rheumatism - November 27, 2013 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Systemic Lupus Erythematosus Source Type: research

A critical role for SOCS3 in promoting M1 macrophage activation and function in vitro and in vivo.
This article is protected by copyright. All rights reserved. PMID: 24088176 [PubMed - as supplied by publisher]
Source: Immunology - September 21, 2013 Category: Allergy & Immunology Authors: Arnold CE, Whyte CS, Gordon P, Barker RN, Rees AJ, Wilson HM Tags: Immunology Source Type: research

P2X7 blockade attenuates lupus nephritis by inhibiting NLRP3/ASC/caspase‐1 activation
Conclusion. Activation of the P2X7 signaling pathway accelerates murine LN by activating NLRP3/ASC/caspase‐1 inflammasome, resulting in increased IL‐1β and enhanced Th17 cell polarization. Thus, targeting the P2X7/NLRP3 pathway as a therapeutic strategy for lupus patients should be considered. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - September 10, 2013 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Full Length Source Type: research