The novel involvement of podocyte autophagic activity in the pathogenesis of lupus nephritis.

CONCLUSIONS: This study demonstrates that autophagic activity of podocytes is a crucial factor in renal injury by directly affecting the function of podocyte; thus, inhibiting this activity during the early stages of LN is implicated as a potential therapeutic strategy for delaying the progression of LN. Also, clinical application in LN needs to consider patients' pathological type and drugs' comprehensive effectiveness.
PMID: 29446059 [PubMed - as supplied by publisher]

Source: Histology and Histopathology - February 17, 2018 Category: Cytology Tags: Histol Histopathol Source Type: research