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Condition: Age-Related Macular Degeneration (AMD)

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Total 41 results found since Jan 2013.

Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1 α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells
ConclusionDEC2 could upregulate retinalVEGF gene expression through modulation of HIF1 α levels under hypoxic conditions.
Source: Japanese Journal of Ophthalmology - September 24, 2018 Category: Opthalmology Source Type: research

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival
In conclusion, we clarified the relationship between acceleration of the autophagy pathway and the cytoprotective effects of Nrf2 activation in RPE cells and zebrafish retina. These findings indicated that Nrf2 activation could be a promising therapeutic approach for non-exudative AMD by supporting RPE maintenance.Graphical abstract
Source: Redox Biology - September 5, 2018 Category: Biology Source Type: research

Role of retinal pigment epithelium-derived exosomes and autophagy in new blood vessel formation.
Abstract Autophagy and exosome secretion play important roles in a variety of physiological and disease states, including the development of age-related macular degeneration. Previous studies have demonstrated that these cellular mechanisms share common pathways of activation. Low oxidative damage in ARPE-19 cells, alters both autophagy and exosome biogenesis. Moreover, oxidative stress modifies the protein and genetic cargo of exosomes, possibly affecting the fate of surrounding cells. In order to understand the connection between these two mechanisms and their impact on angiogenesis, stressed ARPE-19 cells were ...
Source: J Cell Mol Med - August 21, 2018 Category: Molecular Biology Authors: Atienzar-Aroca S, Serrano-Heras G, Freire Valls A, Ruiz de Almodovar C, Muriach M, Barcia JM, Garcia-Verdugo JM, Romero FJ, Sancho-Pelluz J Tags: J Cell Mol Med Source Type: research

Osmotic and hypoxic induction of the complement factor C9 in cultured human retinal pigment epithelial cells: Regulation of VEGF and NLRP3 expression.
Conclusions: The expression of the C9 gene in cultured RPE cells is highly induced by extracellular hyperosmolarity, hypoxia, and oxidative stress. The data may support the assumption that C9 gene expression may stimulate the expression of inflammatory (NLRP3) and angiogenic growth factors (VEGF) in RPE cells. Extracellular C9 protein may attenuate this effect, in part via negative regulation of the C9 mRNA level. PMID: 30090015 [PubMed - in process]
Source: Molecular Vision - August 11, 2018 Category: Molecular Biology Tags: Mol Vis Source Type: research

Cancers, Vol. 10, Pages 80: Aptamer Therapeutics in Cancer: Current and Future
mi Tanaka Aptamer-related technologies represent a revolutionary advancement in the capacity to rapidly develop new classes of targeting ligands. Structurally distinct RNA and DNA oligonucleotides, aptamers mimic small, protein-binding molecules and exhibit high binding affinity and selectivity. Although their molecular weight is relatively small—approximately one-tenth that of monoclonal antibodies—their complex tertiary folded structures create sufficient recognition surface area for tight interaction with target molecules. Additionally, unlike antibodies, aptamers can be readily chemically synthesized and modifi...
Source: Cancers - March 19, 2018 Category: Cancer & Oncology Authors: Yoshihiro Morita Macall Leslie Hiroyasu Kameyama David Volk Takemi Tanaka Tags: Review Source Type: research

Inhibition of YAP ameliorates choroidal neovascularization via inhibiting endothelial cell proliferation.
Conclusions: This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. PMID: 29422766 [PubMed - in process]
Source: Molecular Vision - February 11, 2018 Category: Molecular Biology Tags: Mol Vis Source Type: research

Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells.
Abstract Age-related macular degeneration (AMD) is an irreversible vision loss disease that primarily results from oxidative stress that causes oxidative damage to the retinal pigment epithelial (RPE) cells. Hesperetin (Hesp) is a common flavanone glycoside compound that has been demonstrated to exhibit a variety of biological and pharmacological properties that include anti-inflammatory and antioxidant properties. The aim of this study is to explore the ability of Hesp to attenuate oxidative damage in hydrogen peroxide (H2O2)-stimulated ARPE-19 cells. The results indicated that Hesp treatment not only increased c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 15, 2017 Category: Drugs & Pharmacology Authors: Zhu C, Dong Y, Liu H, Ren H, Cui Z Tags: Biomed Pharmacother Source Type: research

Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells
Publication date: April 2017 Source:Biomedicine & Pharmacotherapy, Volume 88 Author(s): Chao Zhu, Yuchen Dong, Haile Liu, Hua Ren, Zhihua Cui Age-related macular degeneration (AMD) is an irreversible vision loss disease that primarily results from oxidative stress that causes oxidative damage to the retinal pigment epithelial (RPE) cells. Hesperetin (Hesp) is a common flavanone glycoside compound that has been demonstrated to exhibit a variety of biological and pharmacological properties that include anti-inflammatory and antioxidant properties. The aim of this study is to explore the ability of Hesp to attenuate ...
Source: Biomedicine and Pharmacotherapy - January 15, 2017 Category: Drugs & Pharmacology Source Type: research

Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light.
In this study, we evaluated the effect of blue light exposure on photoreceptors and its relationship to Nrf2 using cultured murine photoreceptor (661W) cells. 661W cells were exposed to blue light at 2500 lux. Exposure to blue light for 6-24 h resulted in a significant increase in intracellular reactive oxygen species (ROS) and death of 661W cells in a time-dependent fashion. Blue light exposure resulted in activation of Nrf2, as indicated by an increase in nuclear translocation of Nrf2. This was associated with a significant induction of expression of Nrf2 as well as an array of Nrf2 target genes, including antioxidant g...
Source: Experimental Eye Research - December 2, 2016 Category: Opthalmology Authors: Chen WJ, Wu C, Xu Z, Kuse Y, Hara H, Duh EJ Tags: Exp Eye Res Source Type: research

Osmotic induction of placental growth factor in retinal pigment epithelial cells in vitro: contribution of NFAT5 activity.
Abstract One risk factor of neovascular age-related macular degeneration is systemic hypertension; hypertension is mainly caused by extracellular hyperosmolarity after consumption of dietary salt. In retinal pigment epithelial (RPE) cells, high extracellular osmolarity induces vascular endothelial growth factor (VEGF)-A (Hollborn et al. in Mol Vis 21:360-377, 2015). The aim of the present study was to determine whether extracellular hyperosmolarity and chemical hypoxia trigger the expression of further VEGF family members including placental growth factor (PlGF) in human RPE cells. Hyperosmotic media were made up ...
Source: Molecular Biology Reports - May 25, 2016 Category: Molecular Biology Authors: Hollborn M, Reichmuth K, Prager P, Wiedemann P, Bringmann A, Kohen L Tags: Mol Biol Rep Source Type: research

Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells
Publication date: Available online 4 May 2016 Source:Life Sciences Author(s): Po-Min Yang, Zhi-Zhen Wu, Yu-Qi Zhang, Being-Sun Wung Aims Age-related macular degeneration (AMD) is one of the most common diseases leading to blindness in elderly people. The progression of AMD may be prevented through anti-inflammation and antioxidation in retinal pigment epithelial (RPE) cells. Lycopene, a carotenoid, has been shown to possess both antioxidative and anti-inflammatory properties. This research was conducted to detail the mechanisms of these effects of lycopene-treated RPE cells. Main methods We exposed ARPE-19 cells to ...
Source: Life Sciences - May 4, 2016 Category: Biology Source Type: research

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.
Abstract Bromodomain-containing proteins are vital for controlling the expression of many pro-inflammatory genes. Consequently, compounds capable of inhibiting specific bromodomain-facilitated protein-protein interactions would be predicted to alleviate inflammation, making them valuable agents in the treatment of diseases caused by dysregulated inflammation, such as age-related macular degeneration. Here, we assessed the ability of known inhibitors JQ-1, PFI-1, and IBET-151 to protect from the inflammation and cell death caused by etoposide exposure in the human retinal pigment epithelial cell line, ARPE-19. The ...
Source: Biochemical Pharmacology - April 18, 2016 Category: Drugs & Pharmacology Authors: Hytti M, Tokarz P, Määttä E, Piippo N, Korhonen E, Suuronen T, Honkakoski P, Kaarniranta K, Lahtela-Kakkonen M, Kauppinen A Tags: Biochem Pharmacol Source Type: research

TNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activation.
CONCLUSIONS: Our results support the thinking that TNF-α contributes to CNV by upregulating VEGF production in RPE cells through ROS-dependent activation of β-catenin signaling. These results provide mechanisms of crosstalk between inflammatory mediator, TNF-α, and ROS in RPE cells. PMID: 26900328 [PubMed - in process]
Source: Molecular Vision - February 25, 2016 Category: Molecular Biology Tags: Mol Vis Source Type: research

The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation
In conclusion, our data suggest that RTA 408 protect primary human RPE cells from oxidative stress-induced damage by activating Nrf2 and its downstream genes.
Source: Redox Biology - December 20, 2015 Category: Biology Source Type: research

RAGE mediated intracellular Aβ uptake contributes to the breakdown of tight junction in retinal pigment epithelium.
In this study, we demonstrated that intracellular Aβ was found concomitantly with the breakdown of tight junction in RPE after subretinal injection of Aβ into the mouse eye. We also presented evidence that receptor for advanced glycation end products (RAGE) contributed to endocytosis of Aβ in RPE. siRNA-mediated knockdown of RAGE prevented intracellular Aβ accumulation as well as subsequent tight junction breakdown in RPE. In addition, we found that RAGE-mediated p38 MAPK signaling contributed to endocytosis of Aβ. Blockade of RAGE/p38 MAPK signaling inhibited Aβ endocytosis, thereby preventing tight junction breakdo...
Source: Oncotarget - October 3, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research