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Condition: Keloids

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Total 29 results found since Jan 2013.

AMF siRNA treatment of keloid through inhibition signaling pathway of RhoA/ROCK1
In conclusion, AMF siRNA is expected to be a novel strategy to treat KD by inhibiting signaling pathway of RhoA/ROCK1.
Source: Genes and Diseases - May 19, 2018 Category: Genetics & Stem Cells Source Type: research

Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts.
CONCLUSION: Hsp70 overexpression likely plays an important role in the excessive collagen production by keloid fibroblasts. RNA interference has therapeutic potential for the treatment of keloids. PMID: 26446645 [PubMed - in process]
Source: Yonsei Medical Journal - October 9, 2015 Category: Universities & Medical Training Authors: Shin JU, Lee WJ, Tran TN, Jung I, Lee JH Tags: Yonsei Med J Source Type: research

Treatment of keloids through Runx2 siRNA ‑induced inhibition of the PI3K/AKT signaling pathway.
In conclusion, the findings of the present study indicated that Runx2 silencing in HKFs might significantly inhibit the cell proliferation, migration and the expression levels of ECM‑related proteins, and promote apoptosis via suppressing the PI3K/AKT signaling pathway. Thus, Runx2 siRNA treatment may reverse the pathological phenotype of keloids through the inhibition of PI3K/AKT signaling in patients. PMID: 33200804 [PubMed - in process]
Source: Molecular Medicine - November 18, 2020 Category: Molecular Biology Authors: Lv W, Wu M, Ren Y, Luo X, Hu W, Zhang Q, Wu Y Tags: Mol Med Rep Source Type: research

Wnt2 knock down by RNAi inhibits the proliferation of in vitro-cultured human keloid fibroblasts
To study the effect of knocking down wingless-related MMTV integration site 2 (Wnt2) expression by RNAi on the growth and signaling pathways of ex vitro-cultured keloid fibroblasts (KFB). Human KFB were isolated from 10 keloid patient specimens. The KFB cells were then transfected with 4 pairs of small interfering RNA (siRNA) targeting human Wnt2, respectively. Reverse transcriptase-polymerase chain reaction and Western blot analysis were conducted to verify the knock down of Wnt2, and the expression of β-catenin glycogen synthase kinase-3β (GSK-3β) and cyclin D1 were examined. siRNA Wnt2 transfection (siWnt2) resulte...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Quality Improvement Study Source Type: research

NADPH oxidase‐2 is a key regulator of human dermal fibroblasts: a potential therapeutic strategy for the treatment of skin fibrosis
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - June 30, 2014 Category: Dermatology Authors: Guo‐You Zhang, Liang‐Cai Wu, Tao Dai, Shi‐Yi Chen, An‐Yuan Wang, Kang Lin, Da‐Mu Lin, Jing‐Quan Yang, Biao Cheng, Li Zhang, Wei‐Yang Gao, Zhi‐Jie Li Tags: Regular Article Source Type: research

Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue.
CONCLUSION: Collectively, our data indicate that Nrf2 expression is downregulated in keloid tissues, and that Nrf2 is involved in the development of apoptosis in Nrf2 siRNA-transfected fibroblasts. We propose that a defective antioxidant system and apoptotic dysregulation may participate in keloid pathogenesis. PMID: 26512164 [PubMed]
Source: Annals of Dermatology - October 31, 2015 Category: Dermatology Tags: Ann Dermatol Source Type: research

Role of Homeodomain-Interacting Protein Kinase 2 in the Pathogenesis of Tissue Fibrosis in Keloid-Derived Keratinocytes
Abstract: Epithelial-mesenchymal transition (EMT) plays a critical role in fibrotic keloid formation, which is characterized by excessive collagen and extracellular matrix synthesis and deposition. Growing evidence suggests that the serine/threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) acts upstream of several major fibrosis signaling pathways; however, the role of HIPK2 in the keloid fibrogenesis remains unknown. In the current study, we investigated the roles of HIPK2 in the pathogenesis of keloids. Primary normal skin and keloid keratinocytes were cultured and pretreated with transforming growth facto...
Source: Annals of Plastic Surgery - November 11, 2017 Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research

The mechanisms of β-catenin on keloid fibroblast cells proliferation and apoptosis.
CONCLUSIONS: Knockdown of β-catenin significantly decreased the proliferation and increased apoptosis of KFB, which could inhibit the formation of pathological scar. PMID: 29509234 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The molecular mechanism of GADD153 in apoptosis of keloid fibroblasts exposed to botulinum toxin type A
J Cell Mol Med. 2021 Sep 2. doi: 10.1111/jcmm.16881. Online ahead of print.ABSTRACTApoptosis plays a key role in keloids. Growth arrest and DNA damage-inducible gene 153 (GADD153) is regulated by apoptosis. Botulinum toxin type A (BTXA) can induce apoptosis in keloid fibroblasts. This research aimed to explore the hypothesis that GADD153 mediates apoptosis in keloid fibroblasts exposed to BTXA. BTXA significantly induced GADD153 protein and mRNA expression in keloid fibroblasts. Treatment with c-Jun N-terminal kinase (JNK) inhibitor SP600125, JNK small interfering RNA (siRNA) and tumour necrosis factor-alpha (TNF-α) antib...
Source: J Cell Mol Med - September 2, 2021 Category: Molecular Biology Authors: Ming-Shiuan Nien Wen-Pin Cheng Jun Feng Yong-Yan Cui Source Type: research

miR-21 promotes collagen production in keloid via Smad7
Conclusions miR-21 promoted collagen production in keloid by negatively regulating the expression of the Smad7.
Source: Burns - October 4, 2016 Category: Dermatology Source Type: research

1063 Topically applied NanoFlares to measure gene expression in vivo: Proof-of-concept
Spherical nucleic acids (SNAs) are topical agents that penetrate human skin to knock down genes via antisense and siRNA pathways. NanoFlares, SNAs that release sequence-specific fluorescence when binding to intracellular mRNA targets, measure mRNA levels in live cells. We hypothesized that NanoFlares could be topically applied to measure gene expression in vivo. As proof-of-concept, we detected connective tissue growth factor (CTGF), known to be increased in hypertrophic scars and keloids. Using fibroblasts from normal skin, keloids, hypertrophic scars and peri-scar tissue, we found that: a) NanoFlares are specific; b) exp...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: A.S. Paller, D. Yeo, C. Wiraja, C. Mirkin, C. Xu Tags: Pharmacology and Drug Development Source Type: research

Keloid Core Factor CTRP3 Overexpression Significantly Controlled TGF- < em > β < /em > 1-Induced Propagation and Migration in Keloid Fibroblasts
CONCLUSION: CTRP3 exerted an antifibrotic role through inhibiting proliferation, migration, and ECM accumulation of KFs via regulating TGF-β1/Smad signal path.PMID:37091895 | PMC:PMC10115533 | DOI:10.1155/2023/9638322
Source: Disease Markers - April 12, 2023 Category: Laboratory Medicine Authors: Lin He Chan Zhu Huicong Dou Xueyuan Yu Jing Jia Maoguo Shu Source Type: research