Treatment of keloids through Runx2 siRNA ‑induced inhibition of the PI3K/AKT signaling pathway.

In conclusion, the findings of the present study indicated that Runx2 silencing in HKFs might significantly inhibit the cell proliferation, migration and the expression levels of ECM‑related proteins, and promote apoptosis via suppressing the PI3K/AKT signaling pathway. Thus, Runx2 siRNA treatment may reverse the pathological phenotype of keloids through the inhibition of PI3K/AKT signaling in patients.
PMID: 33200804 [PubMed - in process]

Source: Molecular Medicine - November 18, 2020 Category: Molecular Biology Authors: Lv W, Wu M, Ren Y, Luo X, Hu W, Zhang Q, Wu Y Tags: Mol Med Rep Source Type: research