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Cancer: Lung Cancer
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Total 1667 results found since Jan 2013.
Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1
In this study, the role of lung cancer associated transcript 1 (lncRNA LUCAT 1) in glioma occurrence and development, as well as its possible regulatory mechanism, was explored. We utilized the gene chip technology in the preliminary experiment, and based on the experiment results, selected LUCAT1（NONHSAT102745）, which was significantly upregulated in glioma, and ATP-binding cassette Subfamily B member l (ABCB1), which was significantly down-regulated in co-expression analysis, for study. Next, the expression of LUCAT1 and ABCB1 in cells and tissues was immediately evaluated. Subsequently, the cells were transfected wi...
Source: Experimental Cell Research - October 21, 2022 Category: Cytology Authors: Xia Wu Lvmeng Song Xiangrong Chen Yalan Zhang Shun Li Xiaoping Tang Source Type: research
PDS5B inhibits the proliferation of A549 human lung cancer cells via downregulation of Wnt5a
Conclusion PDS5B inhibits lung cancer cell proliferation by down-regulating Wnt5a expression.PMID:36631010
Source: Cancer Control - January 11, 2023 Category: Cancer & Oncology Authors: Li Ma Tongtong Ma Wenjing Zhou Juan Li Yuyun Li Hui Xu Source Type: research
S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
ConclusionOur study suggests that the S100A8/A9-RAGE signal pathway is the mainstream of the inflammation-immune response induced in cancer progression in CSE-related smoke-induced lung carcinogenesis in vitro and in vivo. Further studies are needed to identify the therapeutic targets of cigarette smoke-induced inflammation and immunosuppression in the tumor microenvironment.
Source: Molecular and Cellular Toxicology - March 15, 2023 Category: Cytology Source Type: research
Aberrant PI3K δ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
ConclusionIn summary, our study has suggested a promising potential of utilizing PI3Kδ-S (an oncogenic isoform conferring drug resistance and exempt from PTEN regulation) as a prognostic biomarker and drug target in advanced endocrine cancers.
Source: Frontiers in Endocrinology - August 21, 2023 Category: Endocrinology Source Type: research
Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel.
Abstract
Metformin, an extensively used and well-tolerated drug for treating individuals with type 2 diabetes, has recently gained significant attention as an anticancer drug. On the other hand, paclitaxel (Taxol) is a new antineoplastic drug that has shown promise in the treatment of non-small cell lung cancer (NSCLC). High expression levels of excision repair cross-complementary 1 (ERCC1) in cancers have been positively associated with the DNA repair capacity and a poor prognosis in NSCLC patients treated with platinum-containing chemotherapy. In this current study, paclitaxel was found to increase phosphorylati...
Source: Biochemical Pharmacology - December 7, 2012 Category: Drugs & Pharmacology Authors: Tseng SC, Huang YC, Chen HJ, Chiu HC, Huang YJ, Wo TY, Weng SH, Lin YW Tags: Biochem Pharmacol Source Type: research
Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells
Conclusions:
These data together show that Mirk/Dyrk1B mediates cell cycle and survival via interacting with MAPK/ERK signals and simultaneous inhibition of both pathways may be a novel therapeutic target for human cancer.
Source: Cancer Cell International - January 11, 2013 Category: Cancer & Oncology Authors: Jingchun GaoYi ZhaoYunyi LvYamin ChenBing WeiJianxin TianZhihai YangFandou KongJian PangJiwei LiuHong Shi Source Type: research
Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance.
In this study, we investigated the role of Nrf2 in the regulation of antiapoptotic Bcl-xL protein and its effect on cellular apoptosis. Treatment of mouse Hepa-1 cells with the antioxidant tert-butylhydroquinone led to the induction of Bcl-xL gene expression. Promoter mutagenesis, transfection, and chromatin immunoprecipitation assays identified an ARE between nucleotides -608 and -600 in the forward strand of the proximal Bcl-xL promoter that bound to Nrf2 and led to increased Bcl-xL gene expression. In addition, short interfering RNA (siRNA) inhibition and overexpression of Nrf2 led to a respective decrease and increase ...
Source: Free Radical Biology and Medicine - December 27, 2012 Category: Biology Authors: Niture SK, Jaiswal AK Tags: Free Radic Biol Med Source Type: research
Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE2 and PGE3 and Alteration of Akt Phosphorylation
Abstract
The beneficial effects of omega‐3 fatty acids are believed to be due in part to selective alteration of arachidonate metabolism that involves cyclooxygenase (COX) enzymes. Here we investigated the effect of eicosapentaenoic acid (EPA) on the proliferation of human non‐small cell lung cancer A549 (COX‐2 over‐expressing) and H1299 (COX‐2 null) cells as well as their xenograft models. While EPA inhibited 50% of proliferation of A549 cells at 6.05 µM, almost 80 µM of EPA was needed to reach similar levels of inhibition of H1299 cells. The formation of prostaglandin (PG)E3 in A549 cells was almost three...
Source: Molecular Carcinogenesis - January 31, 2013 Category: Molecular Biology Authors: Peiying Yang, Carrie Cartwright, Diana Chan, Jibin Ding, Edward Felix, Yong Pan, Jihai Pang, Patrea Rhea, Keith Block, Susan M. Fischer, Robert A. Newman Tags: Research Article Source Type: research
TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma
In conclusion, BDNF/TrkB signal is involved in malignant progression of invasiveness and tumorigenicity for LCNEC, and may be a potential target for LCNEC without standard therapy.
Source: Lung Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Seiichi Odate, Katsuya Nakamura, Hideya Onishi, Masayuki Kojima, Akihiko Uchiyama, Kenji Nakano, Masato Kato, Masao Tanaka, Mitsuo Katano Tags: Carcinogenesis and molecular biology Source Type: research
Thromboxane A2 receptor‐mediated release of matrix metalloproteinase‐1 (MMP‐1) induces expression of monocyte chemoattractant protein‐1 (MCP‐1) by activation of protease‐activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells
Abstract
Matrix metalloproteinases (MMPs) and monocyte chemoattractant protein‐1 (MCP‐1, CCL2) are known to be upregulated in many tumors. Their roles in tumor invasion and metastasis are being uncovered. How they are related to each other and involved in tumor progression remains to be determined. Earlier it was reported that I‐BOP‐initiated activation of thromboxane A2 receptor (TP) induced the release of MMP‐1, MMP‐3, and MMP‐9 from lung cancer A549 cells overexpressing TPα (A549‐TPα). Herein it was found that MMP‐1, but not MMP‐3 or MMP‐9, induced the expression of MCP‐1 in A549 cells. Conditi...
Source: Molecular Carcinogenesis - March 8, 2013 Category: Molecular Biology Authors: Xiuling Li, Hsin‐Hsiung Tai Tags: Research Article Source Type: research
Functional disruption of macrophage migration inhibitory factor (MIF) suppresses proliferation of human H460 lung cancer cells by caspase-dependent apoptosis
Conclusions:
In a model of NSCLC, knockdown of MIF mRNA expression dampened H460 proliferation by mechanisms partly dependent on entry of cells into apoptosis and enhanced production of caspase-3 and -4. MIF expression may thus be important in NSCLC progression. Targeting MIF may have clinical utility in the management of human lung cancer.
Source: Cancer Cell International - March 24, 2013 Category: Cancer & Oncology Authors: Yubiao GuoJunna HouYifeng LuoDujuan Wang Source Type: research
Lipoplex mediated silencing of membrane regulators (CD46, CD55 and CD59) enhances complement-dependent anti-tumor activity of trastuzumab and pertuzumab
Abstract: The therapeutic potential of anticancer antibodies is limited by the resistance of tumor cells to complement-mediated attack, primarily through the over-expression of membrane complement regulatory proteins (mCRPs: CD46, CD55 and CD59). Trastuzumab, an anti- HER2 monoclonal antibody, approved for the treatment of HER2-positive breast and gastric cancers, exerts only minor complement-mediated cytotoxicity (CDC). Pertuzumab is a novel anti-HER2 monoclonal antibody, which blocks HER2 dimerization with other ligand-activated HER family members. Here, we explored the complement-mediated anti-tumor effects of trastuzum...
Source: Molecular Oncology - February 27, 2013 Category: Cancer & Oncology Authors: Srinivas Mamidi, Marc Cinci, Max Hasmann, Volker Fehring, Michael Kirschfink Tags: Papers Source Type: research
Characterization of a Novel Long Non-Coding RNA, SCAL1, Induced by Cigarette Smoke and Elevated in Lung Cancer Cell Lines.
This report describes a novel long non-coding RNA (LncRNA) that is induced by cigarette smoke extract (CSE) both in vitro and in vivo and is elevated in numerous lung cancer cell lines. We have termed this lncRNA, SCAL1 (Smoke and Cancer Associated LncRNA 1). This lncRNA is located in chromosome 5 and initial sequencing analysis reveals a transcript with 4 exons and three introns. Expression of SCAL1 is regulated transcriptionally by NRF2 as determined by siRNA knockdown of NRF2 and KEAP1. An NF-E2 motif is identified in the promoter region that shows binding to NRF2 following its activation. Functionally, siRNA knockdown ...
Source: American Journal of Respiratory Cell and Molecular Biology - May 14, 2013 Category: Molecular Biology Authors: Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R Tags: Am J Respir Cell Mol Biol Source Type: research
Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.
CONCLUSION: This study identified a wide array of druggable genes for both lung and head and neck cancer. In particular, multiple genes involved in the G2-M checkpoint were shown to be essential for tumor cell survival, indicating their potential as anticancer targets. Clin Cancer Res; 19(8); 1994-2003. ©2013 AACR.
PMID: 23444224 [PubMed - in process]
Source: Clinical Lung Cancer - April 15, 2013 Category: Cancer & Oncology Authors: Martens-de Kemp SR, Nagel R, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJ, Brakenhoff RH Tags: Clin Cancer Res Source Type: research
RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy.
CONCLUSIONS: Our novel findings add to the knowledge of RRM2 in regulating expression of the anti-apoptotic protein Bcl-2 and reveal a critical link between RRM2 and Bcl-2 in apoptosis signaling.
PMID: 23719266 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - May 29, 2013 Category: Cancer & Oncology Authors: Rahman MA, Amin AR, Wang D, Koenig L, Nannapaneni S, Chen Z, Wang Z, Sica GL, Deng X, Chen ZG, Shin DM Tags: Clin Cancer Res Source Type: research
