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Specialty: Gastroenterology
Cancer: Adenocarcinoma

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Total 20 results found since Jan 2013.

Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
ConclusionThese findings demonstrate a previously unidentified vitamin D/VDR-MUC1 signaling axis involved in the regulation of gemcitabine resistance in PDA and suggests that combinational therapies that include targeted activation of vitamin D/VDR signaling may improve the outcomes of patients with PDA.
Source: Digestive Diseases and Sciences - April 18, 2023 Category: Gastroenterology Source Type: research

EZH2 Regulates Intestinal Inflammation and Necroptosis Through the JNK Signaling Pathway in Intestinal Epithelial Cells
ConclusionOur data suggest that EZH2 plays an important role in the development of intestinal inflammation and necroptosis. Hence, EZH2 could be a potential therapeutic target for IBD.
Source: Digestive Diseases and Sciences - July 3, 2019 Category: Gastroenterology Source Type: research

Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway
ConclusionsCircular RNA ciRS-7 plays an oncogene role in PDAC, partly by targeting miR-7 and regulating the EGFR/STAT3 signaling pathway.
Source: Hepatobiliary and Pancreatic Diseases International - March 10, 2019 Category: Gastroenterology Source Type: research

Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.
CONCLUSION: HuR mediated overexpression of IAP1 significantly correlates with poor outcomes and early progression of pancreatic cancer. Further studies are needed to assess the underlying mechanisms. PMID: 30670910 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z Tags: World J Gastroenterol Source Type: research

Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells
ConclusionsOur results highlight KRT17 as a possible biomarker in gastric cancer promoting tumor growth, motility, and invasion, and suggest that KRT17 can be a valuable molecular target for development of anti-gastric cancer-specific therapies.
Source: Gastric Cancer - March 14, 2017 Category: Gastroenterology Source Type: research

The role of MALAT-1 in the invasion and metastasis of gastric cancer.
CONCLUSIONS: MALAT-1 may promote the migration and invasion of GC cells in part by regulating EMT. PMID: 28276823 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - March 11, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with low survival rates and limited therapeutic options. Thus elucidation of signaling pathways involved in PDAC pathogenesis is essential for identifying novel potential therapeutic gene targets. Here, we used a systems approach to elucidate those pathways by integrating gene and microRNA profiling analyses together with CRISPR/Cas9 technology to identify novel transcription factors involved in PDAC pathogenesis. FOXA2 transcription factor was found to be significantly downregulated in PDAC relative to control pancreatic tissues. Functional experiments reveal...
Source: AJP: Gastrointestinal and Liver Physiology - June 7, 2016 Category: Gastroenterology Authors: Vorvis, C., Hatziapostolou, M., Mahurkar-Joshi, S., Koutsioumpa, M., Williams, J., Donahue, T. R., Poultsides, G. A., Eibl, G., Iliopoulos, D. Tags: CALL FOR PAPERS Source Type: research

Chemosensitisation of PDAC cell lines by the VCP inhibitor NMS-873
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is often characterized by defective DNA damage repair (DDR), which can be associated with resistance to DNA damaging chemotherapies. We carried out an siRNA screen assessing the potential of 639 DDR genes as therapeutic and chemosensitisation targets for PDAC. We identified several ubiquitin proteasome pathway regulators, including valosin-containing protein/p97 (VCP), whose silencing decreased cell viability and increased caspase 3/7 activities in the PANC-1 cell line.
Source: Pancreatology - May 31, 2016 Category: Gastroenterology Authors: Yuliana Astuti, Euan Stronach, Edward W. Curry, Hani Gabra, Harpreet S. Wasan, Elaina N. Maginn Source Type: research

Linc00675 is a novel marker of short survival and recurrence in patients with pancreatic ductal adenocarcinoma.
CONCLUSION: Linc00675 may function as an oncogene during PDAC development, and its expression is an independent predictor of unfavorable prognosis in patients with PDAC. PMID: 26309360 [PubMed - as supplied by publisher]
Source: World Journal of Gastroenterology : WJG - August 21, 2015 Category: Gastroenterology Authors: Li DD, Fu ZQ, Lin Q, Zhou Y, Zhou QB, Li ZH, Tan LP, Chen RF, Liu YM Tags: World J Gastroenterol Source Type: research

Long non-coding RNAs era in liver cancer.
Authors: Guerrieri F Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies leading to high mortality rates in the general population and the sixth most common cancer worldwide. HCC is characterized by deregulation of multiple genes and signalling pathways. These genetic effects can involve both protein coding genes as well as non-coding RNA genes. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nt, constituting a subpopulation of ncRNAs. Their biological effects are not well understood compared to small non-coding RNA (microRNAs), but they have been recently recognized to exe...
Source: World Journal of Hepatology - August 12, 2015 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma
ConclusionsPGT expression is an independent predictor of poor survival and is associated with tumor angiogenesis in gastric adenocarcinoma. This article is protected by copyright. All rights reserved.
Source: Journal of Gastroenterology and Hepatology - August 6, 2015 Category: Gastroenterology Authors: Shogo Takeda, Tetsuya Tanigawa, Toshio Watanabe, Hiroshi Tatsuwaki, Yuji Nadatani, Koji Otani, Yasuaki Nagami, Fumio Tanaka, Noriko Kamata, Hirokazu Yamagami, Masatsugu Shiba, Kazunari Tominaga, Yasuhiro Fujiwara, Kazuya Muguruma, Masaichi Ohira, Kosei Hi Tags: Original Article ‐ Gastroenterology (Experimental) Source Type: research

Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner
Conclusions Our results provide novel evidence that tumorigenicity associated with H. pylori infection is linked to inhibition of p53 protein by CagA. We propose a model in which CagA-induced degradation of p53 protein is determined by a relative level of p14ARF. In cells in which p14ARF levels were decreased due to hypermethylation or deletion of the p14ARF gene, H. pylori efficiently degraded p53, whereas p53 is protected in cells expressing high levels of p14ARF.
Source: Gut - June 9, 2015 Category: Gastroenterology Authors: Wei, J., Noto, J. M., Zaika, E., Romero-Gallo, J., Piazuelo, M. B., Schneider, B., El-Rifai, W., Correa, P., Peek, R. M., Zaika, A. I. Tags: Stomach and duodenum, Pancreatic cancer Helicobacter pylori Source Type: research

Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma
Conclusions The enhanced expression of PHD3 might likely contribute to the poor neovascularization and affect the biological characterization in PDAC cancer cells.
Source: Journal of Gastroenterology - December 26, 2014 Category: Gastroenterology Source Type: research

Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells.
CONCLUSION: These results suggest that claudin 1 is an important messenger that regulates TNF-α-induced gene expression and migration in gastric cancer cells. A deeper understanding of these cellular processes may be helpful in establishing new therapeutic strategies for gastric cancer. PMID: 25548484 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 21, 2014 Category: Gastroenterology Authors: Shiozaki A, Shimizu H, Ichikawa D, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Iitaka D, Nakashima S, Nako Y, Liu M, Otsuji E Tags: World J Gastroenterol Source Type: research