Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner

Conclusions
Our results provide novel evidence that tumorigenicity associated with H. pylori infection is linked to inhibition of p53 protein by CagA. We propose a model in which CagA-induced degradation of p53 protein is determined by a relative level of p14ARF. In cells in which p14ARF levels were decreased due to hypermethylation or deletion of the p14ARF gene, H. pylori efficiently degraded p53, whereas p53 is protected in cells expressing high levels of p14ARF.

Source: Gut - June 9, 2015 Category: Gastroenterology Authors: Wei, J., Noto, J. M., Zaika, E., Romero-Gallo, J., Piazuelo, M. B., Schneider, B., El-Rifai, W., Correa, P., Peek, R. M., Zaika, A. I. Tags: Stomach and duodenum, Pancreatic cancer Helicobacter pylori Source Type: research