Chemosensitisation of PDAC cell lines by the VCP inhibitor NMS-873

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is often characterized by defective DNA damage repair (DDR), which can be associated with resistance to DNA damaging chemotherapies. We carried out an siRNA screen assessing the potential of 639 DDR genes as therapeutic and chemosensitisation targets for PDAC. We identified several ubiquitin proteasome pathway regulators, including valosin-containing protein/p97 (VCP), whose silencing decreased cell viability and increased caspase 3/7 activities in the PANC-1 cell line.

Source: Pancreatology - May 31, 2016 Category: Gastroenterology Authors: Yuliana Astuti, Euan Stronach, Edward W. Curry, Hani Gabra, Harpreet S. Wasan, Elaina N. Maginn Source Type: research