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Cancer: Fibrosarcoma

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Total 19 results found since Jan 2013.

Dual stimulus of hyperthermia and intracellular redox environment triggered release of siRNA for tumor-specific therapy
This study demonstrates that the constructed vesicle in combination with hyperthermia could greatly improve the in vivo stability of siRNA-CPPs and synergistically enhance its cancer therapy efficiency. Graphical abstract
Source: International Journal of Pharmaceutics - April 27, 2016 Category: Drugs & Pharmacology Source Type: research

Regulation of Mitophagy by the Gp78 E3 Ubiquitin Ligase.
This study therefore describes a novel role for the ER-associated Gp78 ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy. PMID: 23427266 [PubMed - as supplied by publisher]
Source: Mol Biol Cell - February 20, 2013 Category: Molecular Biology Authors: Fu M, Pierre PS, Shankar J, Wang PT, Joshi B, Nabi IR Tags: Mol Biol Cell Source Type: research

Negatively-regulated necroptosis by autophagy required caspase-6 activation in TNFα-treated murine fibrosarcoma L929 cells.
Abstract Autophagy and necroptosis have been known to be interconnected, while the relationship between autophagy and necroptosis remains unclear. Here, we demonstrated that pan-caspase inhibitor z-VAD-fmk (zVAD) exacerbated TNFα-induced necroptosis and autophagy in murine fibrosarcoma L929 cells. And the RIP-1 inhibitor necrostatin-1 inhibited TNFα+zVAD-induced necroptosis and autophagy. Inhibition of autophagy by 3-methyladenine (3MA) or small interfering RNA (siRNA) against Beclin 1 augmented TNFα-induced necroptosis, while, autophagy inhibition did not influence TNFα+zVAD-induced necroptosis. These results...
Source: International Immunopharmacology - August 10, 2013 Category: Allergy & Immunology Authors: Ye YC, Wang HJ, Chen L, Liu WW, Tashiro SI, Onodera S, Xia MY, Ikejima T Tags: Int Immunopharmacol Source Type: research

The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion
Conclusions: These results indicate that patupilone counteracts an IR-induced MMP activation process by the reduction of secreted TIMP-1 and TIMP-2 proteins, which are required for activation of MMPs. Since IR-induced MMP activity could contribute to tumor progression, treatment combination of IR with patupilone might be of great clinical benefit for tumor therapy.
Source: Radiation Oncology - April 30, 2013 Category: Cancer & Oncology Authors: Polina Furmanova-HollensteinAngela Broggini-TenzerMatthias EggelAnne-Laure MillardMartin Pruschy Source Type: research

Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
Conclusions: Providing first evidence of a cell biological function of CT45, we suggest that this cancer/testis antigen is involved in the modulation of cell morphology, cell adherence and cell motility. Enhanced motility and/or invasiveness of CT45-positive cells could contribute to the more severe disease progression that is correlated to CT45-positivity in several malignancies.
Source: Cell Communication and Signaling - June 10, 2013 Category: Molecular Biology Authors: Anja KoopNadia SellamiSabine Adam-KlagesMarcus LettauDieter KabelitzOttmar JanssenHans-Jürgen Heidebrecht Source Type: research

Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice
Conclusions/interpretationThese results suggest novel roles for DNA-binding proteins and fatty acid signalling in obesity-induced epigenomic regulation of beta cell function.Data availabilityThe next-generation sequencing data in the present study were deposited at ArrayExpress.RNA-Seq:Dataset name: ERR2538129 (Control), ERR2538130 (Diet-induced obesity)Repository name and number: E-MTAB-6718 - RNA-Seq of pancreatic islets derived from mice fed a long-term high-fat diet against chow-fed controls.ChIP-Seq:Dataset name: ERR2538131 (Control), ERR2538132 (Diet-induced obesity)Repository name and number: E-MTAB-6719 - H3K27ac C...
Source: Diabetologia - November 5, 2018 Category: Endocrinology Source Type: research

Molecules, Vol. 25, Pages 5192: Antiglioma Potential of Coumarins Combined with Sorafenib
ubowicz-Gil Coumarins, which occur naturally in the plant kingdom, are diverse class of secondary metabolites. With their antiproliferative, chemopreventive and antiangiogenetic properties, they can be used in the treatment of cancer. Their therapeutic potential depends on the type and location of the attachment of substituents to the ring. Therefore, the aim of our study was to investigate the effect of simple coumarins (osthole, umbelliferone, esculin, and 4-hydroxycoumarin) combined with sorafenib (specific inhibitor of Raf (Rapidly Accelerated Fibrosarcoma) kinase) in programmed death induction in human glioblastom...
Source: Molecules - November 8, 2020 Category: Chemistry Authors: Joanna Sumorek-Wiadro Adrian Zaj ąc Ewa Langner Krystyna Skalicka-Wo źniak Aleksandra Maciejczyk Wojciech Rzeski Joanna Jakubowicz-Gil Tags: Article Source Type: research

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
AbstractGliomas are aggressive brain tumors with very high resistance to chemotherapy throughout the overexpression of multiple intracellular survival pathways. Therefore, the aim of the present study was to investigate for the first time the anticancer activity of LY294002, phosphatidylinositol 3-kinase (PI3K) inhibitor and sorafenib, and rapidly accelerated fibrosarcoma kinase (Raf) inhibitor in the elimination of human glioma cells by programmed cell death. MOGGCCM (anaplastic astrocytoma, III) and T98G (glioblastoma multiforme, IV) cell lines incubated with LY294002 and/or sorafenib were used in the experiments. Simult...
Source: Cell and Tissue Research - July 8, 2021 Category: Cytology Source Type: research

mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in Psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells.
In conclusion, mTOR inactivation by ROS-JNK-p53 pathway played an important role in autophagy-dependent senescence in PAB-treated L929 cells. PMID: 23810968 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - June 26, 2013 Category: Drugs & Pharmacology Authors: Qi M, Zhou H, Fan S, Li Z, Yao G, Tashiro SI, Onodera S, Xia M, Ikejima T Tags: Eur J Pharmacol Source Type: research

A mechanistic study on the metastasis inducing function of FUS‐CHOP fusion protein in liposarcoma
Abstract The FUS‐CHOP fusion protein has been found to be instrumental for specific oncogenic processes in liposarcoma, but its ability to induce metastasis and the underlying mechanisms by which this can be achieved remain unknown. In order to dissect its functional role in this context, we stably overexpressed this protein in SW872 liposarcoma and HT1080 fibrosarcoma cell lines, and were able to demonstrate that forced expression of FUS‐CHOP significantly increases migration and invasion, as well as enhances lung and liver metastasis in the in vivo chicken chorioallantoic membrane (CAM) model, that is proliferation i...
Source: International Journal of Cancer - November 28, 2013 Category: Cancer & Oncology Authors: Nitin Patil, Suhail Ahmed Kabeer Rasheed, Mohammed Abba, Jörg Hendrik Leupold, Matthias Schwarzbach, Heike Allgayer Tags: Cancer Cell Biology Source Type: research

Proteomic analysis indicates that overexpression and nuclear translocation of lactoylglutathione lyase (GLO1) is associated with tumor progression in murine fibrosarcoma
This article is protected by copyright. All rights reserved
Source: Electrophoresis - February 1, 2014 Category: Biochemistry Authors: Yufeng Wang, Yasuhiro Kuramitsu, Kazuhiro Tokuda, Futoshi Okada, Byron Baron, Junko Akada, Takao Kitagawa, Kazuyuki Nakamura Tags: Research Article Source Type: research

EPHB4 tyrosine‐kinase receptor expression and biological significance in soft tissue sarcoma
Abstract Soft tissue sarcomas (STS) are heterogeneous malignant tumors of mesenchymal origin. Due to low incidence and high number of different histological subtypes, their pathogenesis and thus potential targets for their therapy remain barely investigated. Several studies revealed significant higher EPHB4 expression in malignancies such as prostate and colorectal cancer showing survival advantages for these tumor cells. Therefore we studied the expression of EPHB4 in a total of 46 clinical human specimens of different STS and human fibroblasts. EPHB4 mRNA and protein expression were significantly increased in synovial sa...
Source: International Journal of Cancer - October 1, 2014 Category: Cancer & Oncology Authors: M Becerikli, B Merwart, MC Lam, P Suppelna, A Rittig, A Mirmohammedsadegh, I Stricker, C Theiss, B.B. Singer, F Jacobsen, L Steinstraesser Tags: Carcinogenesis Source Type: research

Abstract A06: The role of the epidermal growth factor receptor (EGFR) in primary tumor cell escape and development of an intravasation-sustaining vasculature
In this study, we investigated the specific roles of EGFR in the early steps of tumor metastasis such as escape of cancer cells from the primary tumor and development of angiogenic vasculature, the two critical events required for tumor cell intravasation. For this purpose we employed the EGFR-overexpressing highly disseminating variant of human fibrosarcoma HT-1080 cell line, HT-hi/diss, in several independent in vivo CAM models. In the spontaneous metastasis model, siRNA silencing of EGFR significantly reduced the levels of HT-hi/diss intravasation, suggesting a role of EGFR overexpression in tumor cell escape and/or dev...
Source: Cancer Research - January 12, 2015 Category: Cancer & Oncology Authors: Minder, P., Deryugina, E. I., Quigley, J. P. Tags: Tumor-Associated Blood Vessels and Lymphatics Source Type: research

Abstract 3378: Discoidin domain receptor 2 differentially controls HT-1080 cell proliferation in young-adult and old type I collagen 3D matrices
In this study, we analyzed the effect of collagen aging on human HT-1080 fibrosarcoma cell proliferation in 3D matrix model. For this, type I collagen was extracted from tail tendons of young-adult (2 months) and old (2 years) rats. In 3D matrix, the rate of HT-1080 cell growth was significantly lower in young-adult collagen. This was accompanied by a down-regulation of ERK1/2 phosphorylation and an increase in the cyclin-dependent kinase inhibitor p21 expression. Blocking antibodies and siRNA strategy against β1 integrin and AGEs receptor (RAGE) did not increase cell growth in young-adult collagen.Accumulating evidence s...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Saby, C., Garnotel, R., El Btaouri, H., Van Gulick, L., Jeannesson, P., Morjani, H. Tags: Tumor Biology Source Type: research