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UVB-Induced Secretion of IL-1 < em > β < /em > Promotes Melanogenesis by Upregulating TYR/TRP-1 Expression In Vitro
CONCLUSIONS: UVB-induced melanogenesis is mediated in part by IL-1β, leading to upregulation of the TYR/TRP1 expression in melanoma B16 cells. IL-1β can also stimulate the expression of COX-2 and SCF in HaCaT cells, which in turn increase melanin synthesis in melanocytes. These results suggest that anti-inflammatory approaches could possibly mitigate UVB-induced hyperpigmentation.PMID:35572734 | PMC:PMC9106468 | DOI:10.1155/2022/8230646
Source: Biomed Res - May 16, 2022 Category: Research Authors: Chun-Yan Yang Yanni Guo Wen-Juan Wu Mao-Qiang Man Ying Tu Li He Source Type: research

PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes
Conclusion: RIG-I and MDA5 may play a role in the antiviral responses of podocytes.
Source: In Vivo - January 5, 2021 Category: Research Authors: NAKATA, M., SHIMADA, M., NARITA-KINJO, I., NAGAWA, D., KITAYAMA, K., HAMADATE, M., MIURA, N., NOZAKA, M., KAWAMURA, Y., FUJITA, T., MURAKAMI, R., IMAIZUMI, T., NAKAMURA, N., TOMITA, H. Tags: Experimental Studies Source Type: research

miR-652 Promotes Proliferation and Migration of Uveal Melanoma Cells by Targeting HOXA9.
CONCLUSIONS Our data demonstrate an oncogenic role of miR-652 in uveal melanoma, showing that miR-652 may be a useful biomarker for prediction of prognosis for patients with uveal melanoma. PMID: 31740654 [PubMed - in process]
Source: Medical Science Monitor - November 21, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of peptidyl-prolyl isomerase (PIN1) and BRAF signaling to target melanoma.
Authors: Braun C, Schneider N, Pei D, Bosserhoff A, Kuphal S Abstract PIN1 is a phosphorylation-dependent peptidyl-prolyl cis/trans isomerase, overexpressed in many cancers, including melanoma. Our immunohistochemistry data of melanoma patient tissue underline the up-regulation of PIN1 in metastases. Here, we demonstrate important functions of PIN1 and its selective and cell permeable inhibitor 37 for the treatment of melanoma. To analyze its possible role in oncogenesis and as a therapeutic target, we first suppressed PIN1 expression by a siRNA pool. PIN1 knockdown potently inhibited melanoma cell proliferation an...
Source: American Journal of Translational Research - August 11, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells.
CONCLUSION: Our data proves tumor-promoting role of MAGEA3 and provides the rationale to target MAGEA3 and/or its functional mediators like CCL2 for PCA, which may have a better impact in PCA therapy. PMID: 31287009 [PubMed - in process]
Source: Clin Med Res - July 7, 2019 Category: Research Authors: Das B, Senapati S Tags: J Exp Clin Cancer Res Source Type: research

Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/ β-catenin pathway.
In conclusion, we demonstrated that GPNMB contributed to the tumorigenesis of cervical cancer, at least in part, by regulating MMP-2/MMP-9 activity in tumor cells via activation of canonical Wnt/β-catenin signaling. This might be a potential therapeutic target for treating human cervical cancer. PMID: 30484490 [PubMed - in process]
Source: Brazilian Journal of Medical and Biological Research - November 30, 2018 Category: Research Tags: Braz J Med Biol Res Source Type: research

Mitochondrial Complex IV Inhibition and Exogenous Oxidants Potently Synergize in Melanoma Cell Death Induction
In this study, we investigated murine (metastatic B16F10 and non-metastatic B16F0) as well as human (SK-Mel 28) melanoma cells, and compared them with murine (primary fibroblasts) and human (HaCaT keratinocytes) non-cancer cells. Mitochondrial complex IV inhibition was realized using sodium azide (NaN3) and potassium cyanide (KCN) and pharmacological inhibitor ADDA5. Exogenous oxidants were generated using cell culture medium that has been treated with the cold physical plasma effluent of an atmospheric pressure argon plasma jet (kINPen). This plasma-treated medium was subsequently applied to different cells. Metabolic act...
Source: Clinical Plasma Medicine - April 10, 2018 Category: Research Source Type: research

Juxtanuclear Drebrin-Enriched Zone.
Authors: Ludwig-Peitsch WK Abstract Drebrin E contributes to remodeling of the actin cytoskeleton and formation of cell processes. Therefore, its role in cell migration was studied in prototypes of motile cells with prominent lamellipodia such as murine B16F1 melanoma and Swiss 3T3 cells and in human SV80 fibroblasts. Confocal microscopy revealed absence of drebrin from the tips of lamellipodia but enrichment in the tail of the cells, in retraction zones and in a specific juxtanuclear actin filament compartment, named "drebrin-enriched zone." A similar subset of juxtanuclear actin filaments is characterized by the ...
Source: Advances in Experimental Medicine and Biology - September 4, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Expression of G Protein-coupled Receptor 56 Is an Unfavorable Prognostic Factor in Osteosarcoma Patients.
This study aimed at figuring out whether expression of the GPR56 was associated with clinicopathological features of osteosarcoma. Eighty-nine patients who received osteosarcoma operation between March 2004 and February 2011 in Linyi People's Hospital were recruited. Immunohistochemical staining (IHC) was carried out to identify the expression of GPR56 in those osteosarcoma tissues, and our cohort was divided into higher-expression group and lower-expression group according to the cut-off of IHC score. Expression of GPR56 in osteosarcoma tissues was correlated with the TNM stage and overall survival. Univariate and multiva...
Source: The Tohoku Journal of Experimental Medicine - July 13, 2016 Category: Research Authors: Chen Z, Gao P, Li Z Tags: Tohoku J Exp Med Source Type: research

Identification of Preferentially Expressed Antigen of Melanoma as a Potential Tumor Suppressor in Lung Adenocarcinoma.
CONCLUSIONS In line with its roles in controlling cell growth, RPAME regulates multiple critical cell-growth related genes, including IGF1R oncogene. IGF1R up-regulation contributes to increase of cell growth upon the knockdown of PRAME. Taken together, our results suggest that PRAME has inhibitory roles in lung cancer. PMID: 27241212 [PubMed - in process]
Source: Medical Science Monitor - June 1, 2016 Category: Research Tags: Med Sci Monit Source Type: research

α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid.
CONCLUSIONS These results indicate that the combination of these novel natural agents with retinoid acid may be clinically effective in NRAS mutant melanoma. PMID: 27104669 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - April 23, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Dual mechanisms of action of the RNA-binding protein HuR explains its regulatory effect on melanoma cell migration
Overexpression of WNT5A plays a significant role in melanoma cancer progression; however, the mechanism(s) involved remains unknown. In breast cancer, the Human antigen R (HuR) has been implicated in the regulation of WNT5A expression. Here, we demonstrate that endogenous expression of WNT5A correlates with levels of active HuR in HTB63 and WM852 melanoma cells and that HuR binds to WNT5A mRNA in both cell lines. Although the HuR inhibitor MS-444 significantly impaired migration in both melanoma cell lines, it reduced WNT5A expression only in HTB63 cells, as did siRNA knockdown of HuR.
Source: Translational Research - February 23, 2016 Category: Research Authors: Farnaz Moradi, Pontus Berglund, Rickard Linnskog, Karin Leandersson, Tommy Andersson, Chandra Prakash Prasad Source Type: research

Toll-like receptor 4 signaling promotes the migration of human melanoma cells.
Abstract Immune cell Toll-like receptors (TLRs) recognize conserved microbial components, leading to immune and inflammatory responses. However, TLRs are also expressed in cancer cells, including melanoma cells, which express TLR2-4. TLR4 ligands have received attention as immunotherapies; therefore, we assessed the expression of TLR4 in human melanoma specimens (29 primary lesions and 28 metastatic lesions) representing different types of melanoma. A high percentage (≥ 90%) of melanoma lesions expressed TLR4, as judged by immunohistochemistry. Next, the role of TLR4 in cell proliferation and migration was asses...
Source: The Tohoku Journal of Experimental Medicine - September 6, 2014 Category: Research Authors: Takazawa Y, Kiniwa Y, Ogawa E, Uchiyama A, Ashida A, Uhara H, Goto Y, Okuyama R Tags: Tohoku J Exp Med Source Type: research