Review of clinical applications of nitric oxide-containing air-plasma gas flow generated by Plason device
Publication date: Available online 12 November 2020Source: Clinical Plasma MedicineAuthor(s): Alexandra V. Butenko, Anatoly B. Shekhter, Alexander V. Pekshev, Andrey B. Vagapov, Alexey L. Fayzullin, Natalia B. Serejnikova, Nikolay A. Sharapov, Viktoria A. Zaborova, Victor N. Vasilets (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - November 12, 2020 Category: Research Source Type: research

Cold Atmospheric plasma (CAP) as a promising therapeutic option for mild to moderate acne vulgaris: clinical and non-invasive evaluation of two cases.
Publication date: Available online 9 October 2020Source: Clinical Plasma MedicineAuthor(s): Dr. Arisi Mariachiara, Venturuzzo Anna, Gelmetti Alessandra, Guasco Pisani Edoardo, Bassissi Stefania, Rossi Mariateresa, Calzavara-Pinton Piergiacomo (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - October 10, 2020 Category: Research Source Type: research

Canady Cold Plasma Conversion System Treatment: An Effective Inhibitor of Cell Viability in Breast Cancer Molecular Subtypes
Publication date: Available online 7 September 2020Source: Clinical Plasma MedicineAuthor(s): Lawan Ly, Xiaoqian Cheng, Saravana R K Murthy, Taisen Zhuang, Olivia Z Jones, Giacomo Basadonna, Michael Keidar, Jerome Canady (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - September 8, 2020 Category: Research Source Type: research

A comparison of two cold atmospheric helium plasma devices which utilise the same RF power generator
Publication date: Available online 12 August 2020Source: Clinical Plasma MedicineAuthor(s): Cian D. Madigan, Denis O'Sullivan, Liam O'Neill, Darren F. Kavanagh (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - August 13, 2020 Category: Research Source Type: research

Changes in enamel after bleaching pre-treatment with non-thermal atmospheric plasma
Publication date: September–December 2020Source: Clinical Plasma Medicine, Volumes 19–20Author(s): Melissa A. Ruivo, Gabriel Nima, Rafael R. Pacheco, Ailla C.R.A. Lancellotti, Regina G. Palma-Dibb, Juliana J. Faraoni, Luis E.S. Soares, Airton A. Martins, Bruno B. Lopes, Marcelo Giannini (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - August 5, 2020 Category: Research Source Type: research

Effect of Plasma Application Combined to 38% Hydrogen Peroxide on Enamel Color, Composition and Roughness
Publication date: Available online 20 July 2020Source: Clinical Plasma MedicineAuthor(s): Melissa Araújo Ruivo, Gabriel Nima, Rafael Rocha Pacheco, Ailla C.R.A. Lancellotti, Regina G. Palma-Dibb, Juliana J.F. Romano, Luis E.S. Soares, Airton A. Martins, Bruno Bellotti Lopes, Marcelo Giannini (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 20, 2020 Category: Research Source Type: research

Cold atmospheric plasma treatment on failed finger perforator flap: A case report
Publication date: Available online 17 July 2020Source: Clinical Plasma MedicineAuthor(s): Minh Dinh Nguyen, Quynh Thi Do, Thanh-Tu Luong, Ngoc-Thanh Le, Tran-Thuy Nguyen, Thao Phuong Bui, Hoang-Tung Do, Hans Metelmann, Thom Thi Vu (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 18, 2020 Category: Research Source Type: research

Cold Atmospheric Plasma, the Removal of Blood from Steel and its Effect on Staphylococcal Biofilm Formation. A Pilot Study
Publication date: Available online 12 July 2020Source: Clinical Plasma MedicineAuthor(s): Muireann Fallon, Maria Boyle, Sarah Kennedy, Stephen Daniels, Hilary Humphreys (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 12, 2020 Category: Research Source Type: research

Breast Cancer Treatment Using Cold Atmospheric Plasma Generated by the FE-DBD Scheme
Publication date: Available online 12 June 2020Source: Clinical Plasma MedicineAuthor(s): Ban H. Adil, Ahmed Majeed Al-Shammri, Hamid H. Murbit (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - June 13, 2020 Category: Research Source Type: research

Dose-dependent effect of plasma-chemical NO-containing gas flow on wound healing. An experimental study
Publication date: Available online 3 June 2020Source: Clinical Plasma MedicineAuthor(s): Anatoly B. Shekhter, Alexander V. Pekshev, Andrey B. Vagapov, Alexandra V. Butenko, Alexey L. Fayzullin, Tatyana G. Rudenko, Nikolay A. Sharapov, Natalia B. Serejenkova, Victor N. Vasilets (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - June 5, 2020 Category: Research Source Type: research

Inhibition of murine melanoma tumor growth in vitro and in vivo using an argon-based plasma jet
Publication date: Available online 1 June 2020Source: Clinical Plasma MedicineAuthor(s): Alireza Rafiei, Farshad Sohbatzadeh, Seyedehniaz Hadavi, Sander Bekeschus, Mina Alimohammadi, Reza Valadan (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - June 2, 2020 Category: Research Source Type: research

Cold atmospheric pressure plasma treatment to assist the restoration of the apical region of a root canal in endodontic procedures
Publication date: Available online 2 June 2020Source: Clinical Plasma MedicineAuthor(s): Alina Bisag, Michele Manzini, Emanuele Simoncelli, Augusto Stancampiano, Riccardo Tonini, Matteo Gherardi, Vittorio Colombo (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - June 2, 2020 Category: Research Source Type: research

Selective treatments of prostate tumor cells with a cold atmospheric plasma jet
Publication date: Available online 13 March 2020Source: Clinical Plasma MedicineAuthor(s): Mohamed Fofana, Julio Buñay, Florian Judée, Silvère Baron, Sébastien Menecier, Marc Nivoix, Frédéric Perisse, Antoine Vacavant, Xavier Balandraud (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 14, 2020 Category: Research Source Type: research

Wound healing improvement in large animals using an indirect helium plasma treatment
ConclusionsThe obtained results suggest that the plasma action, at the used dose, induces an increase in cell proliferation, a reduction of inflammation, a reduction of the bacterial load, a stimulation of blood vessel formation, and an improvement in the formation of cutaneous adnexa with a positive consequence on hair regrowth. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - February 11, 2020 Category: Research Source Type: research

Combination of Cold Plasma and Pulsed Electric Fields – A Rationale for Cancer Patients in Palliative Care
Publication date: Available online 3 February 2020Source: Clinical Plasma MedicineAuthor(s): Christina M. Wolff, Anna Steuer, Ingo Stoffels, Thomas von Woedtke, Klaus-Dieter Weltmann, Sander Bekeschus, Juergen F. KolbAbstractCancer continues to be a significant threat to human health. Oncotherapy, therefore, relies on the combination of different approaches to increase a patient's chances. If therapeutic options are exhausted, effective palliation can at least still improve the quality of life. Over two decades ago, electrochemotherapy (ECT), which is based on pulsed electric field (PEF) exposures, was introduced in pallia...
Source: Clinical Plasma Medicine - February 3, 2020 Category: Research Source Type: research

Healing of wounds in lower extremities employing a non-thermal plasma
Conclusion: The non-thermal plasma generated in a needle reactor with helium gas is a promising candidate for clinical and therapeutic use in the treatment of neuropathic leg ulcers, with time reduction healing, and it can be applied everyday. In the study conducted, it was found that the non-thermal plasma applied to patients with autoimmune diseases clinically was not beneficial. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - January 30, 2020 Category: Research Source Type: research

Innovative Cold Atmospheric Plasma (iCAP) Decreases Mucopurulent Corneal Ulcer Formation and Edema and Reduces Bacterial Load in Pseudomonas Keratitis
ConclusionOur results strongly suggest that iCAP treatment was effective in improving corneal epithelial defect closure in vitro, reducing ulcer formation and decreasing inflammation in P. aeruginosa infected corneas in vivo and decreasing bacterial loads in P. aeruginosa infected corneas in vivo which led to improved overall cornea health outcomes in vivo. Further studies to investigate iCAP's safety and efficacy against other infectious microbes responsible for causing ulcerative keratitis, with and without co-treatment with antimicrobial therapies are warranted. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - December 28, 2019 Category: Research Source Type: research

Magnetic Field Enhanced Cold Plasma Sterilization
Publication date: Available online 19 October 2019Source: Clinical Plasma MedicineAuthor(s): Madeline A. Mackinder, Keliang Wang, Bocong Zheng, Maheshwar Shrestha, Qi Hua FanAbstractCold plasma sterilization offers an efficient way to sterilize medical components and instruments. This paper reports using a magnetized plasma to realize low-temperature sterilization. A radio frequency dielectric barrier discharge is created in a quartz tube using a mixture of argon and oxygen gas. A uniform amount of Escherichia coli is applied onto glass slides and exposed to the plasma afterglow at different pressures with and without a ma...
Source: Clinical Plasma Medicine - October 19, 2019 Category: Research Source Type: research

Biofilm Inactivation by Synergistic Treatment of Atmospheric Pressure Plasma and Chelating Agents
In this study, we investigated the bacterial biofilm reduction by combined treatment of atmospheric pressure plasma (APP) and chelating agents. Many of hospital acquired infections (HAI) are related to biofilm infections. APP and chelating agents were reported to be effective in bacterial biofilm inactivation and eradication. It is believed that chelating agents disrupt the biofilm formation through bonding metal ions, while APP inactivates bacteria mainly through reactive species [1], [2], [3]. In our study, we used a surface micro-discharge (SMD) driven by sinusoidal power input of 2 kHz and peak to peak voltage of 9 kV ...
Source: Clinical Plasma Medicine - June 22, 2019 Category: Research Source Type: research

Ethanolic extract of the natural product of Daun sirih (Piper betle) leaves may impede the effectiveness of the plasma jet contact style for acute wounds
ConclusionPlasma jet treatment alone is able to promote inflammation, neo-epithelialisation and new collagen formation to accelerate acute wound healing; however, its admixture with EPB may impede such effectiveness. Based on the characterization of the ROS and RNS results, the ethanol solvent may play a primary role in impeding its effectiveness. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - June 13, 2019 Category: Research Source Type: research

Publishers Note
Publication date: June 2019Source: Clinical Plasma Medicine, Volume 14Author(s): (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - May 29, 2019 Category: Research Source Type: research

Can the effect of cold physical plasma-derived oxidants be transported via thiol group oxidation?
ConclusionExtracellular thiol groups scavenge plasma-generated species and form a multitude of covalent modifications. Unexpectedly, human keratinocytes show only small functional consequences for treated physiologic cysteine concentrations. Results for high concentrated cysteine solutions indicate an improved cytostatic/cytotoxic impact by plasma treatment suggesting a potential application as a “preserving agent” of the chemical energy of plasma-derived species. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 28, 2019 Category: Research Source Type: research

When plasma jet is effective for chronic wound bacteria inactivation, is it also effective for wound healing?
ConclusionIn the context of wound healing, the non-contact style of plasma jet treatment may be better than the contact style of plasma jet treatment. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 24, 2019 Category: Research Source Type: research

Safety Evaluation of the Plasma on Ocular Surface Tissue: an Animal Study and Histopathological Findings
ConclusionAccording to the plasma safety results, it seems that plasma soft surgery has the potential to be used as an alternative method for treatment of some of the ocular surface disorders without needing to conventional surgical procedures. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 16, 2019 Category: Research Source Type: research

Cold physical plasma-induced oxidation of cysteine yields reactive sulfur species (RSS)
ConclusionTranslating these data into the in-vivo application, a strong direct oxidation of protein thiol groups with subsequent changes in protein biochemistry must be considered. Plasma derived RSS may in part contribute to the observed biomedical effects of CAP. Care must be taken to control discharge parameter tightly as chemical dynamics at or in the liquid are subject to change easily. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - March 9, 2019 Category: Research Source Type: research

Cold atmospheric plasma (CAP) differently affects migration and differentiation of keratinocytes via hydrogen peroxide and nitric oxide-related products
ConclusionCAP treatment theoretically could kill several birds with one stone—overcome bacterial contamination, improve microcirculation and additionally compensate missing H2O2 and nitric oxide— facilitating wound healing. However, clinical CAP treatment must be well balanced to avoid possible unwanted side effects, such as a delayed healing process and tissue damage. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - November 29, 2018 Category: Research Source Type: research

Wound Healing using Plasma Modified Collagen
Publication date: Available online 27 October 2018Source: Clinical Plasma MedicineAuthor(s): Liam O'Neill, Peter Dobbyn, Mangesh Kulkarni, Abhay PanditAbstractBackgroundWound healing remains a challenge in diabetic or immune-compromised patients and often requires the use of advanced biologic dressings to treat slow healing ulcers. The emergence of plasma medicine has provided some hope for advancement in wound closure rates for non-healing patients and some positive clinical results have already been observed. However, the potential to combine biologic dressings with plasma medicine has not yet been widely explored and th...
Source: Clinical Plasma Medicine - October 27, 2018 Category: Research Source Type: research

Potentiating Anti-Tumor Immunity with Physical Plasma
Publication date: Available online 5 October 2018Source: Clinical Plasma MedicineAuthor(s): Sander Bekeschus, Ramona Clemen, Hans-Robert MetelmannAbstractThe age of checkpoint blockage emphasizes the importance of adaptive antitumor immune responses. This arm of immune defense is key in recognizing molecules via specific receptors to distinguish between self and foreign or mutated structures. Antigen-specific T-cells identify non-self epitopes, tumor-associated antigens, or neo-epitopes on tumors to carry out attacks on malignant cells. Although tumor cells are immunogenic by nature, they have developed strategies to evade...
Source: Clinical Plasma Medicine - October 6, 2018 Category: Research Source Type: research

Surface treatment with non-thermal humid argon plasma as a treatment for allergic contact dermatitis in a mouse model
Publication date: December 2018Source: Clinical Plasma Medicine, Volume 12Author(s): Qing Xiong, Xia Wang, Rui Yin, Lin Xiong, Qiang Chen, Meng-Xue Zheng, Le Xu, Qing-Hua Huang, Michael R HamblinAbstractCold plasma generated at atmospheric pressure has attracted intense interest in biomedical applications, particularly as an antimicrobial treatment. Here we report the therapeutic effect of humidified cold argon plasma on allergic contact dermatitis (ACD) in a mouse model. Treatment was carried out with different gas compositions: argon gas containing small amounts of either N2, O2, or H2O. The best effect was obtained usin...
Source: Clinical Plasma Medicine - October 6, 2018 Category: Research Source Type: research

Study of a Cold Atmospheric Pressure Plasma jet device for indirect treatment of Squamous Cell Carcinoma
Publication date: Available online 5 September 2018Source: Clinical Plasma MedicineAuthor(s): S. Pereira, E. Pinto, P.A. Ribeiro, S. SérioABSTRACTThe possibility of obtaining plasmas at low temperatures and atmospheric conditions, the Cold Atmospheric Plasmas (CAPs), has triggered several studies on its possible medical applications. The use of CAPs devices applied to oncological treatments is still in a pre-clinical stage, but early investigations have shown promising results, both in vitro and in vivo. In this work, is reported the study of a custom made Cold Atmospheric Pressure Plasma jet device for indirect tre...
Source: Clinical Plasma Medicine - September 6, 2018 Category: Research Source Type: research

Comparative Study on Manuka and Indonesian Honeys to Support the Application of Plasma Jet during Proliferative Phase on Wound Healing
Publication date: Available online 11 August 2018Source: Clinical Plasma MedicineAuthor(s): Eka Sakti Wahyuningtyas, Arya Iswara, Yunita Sari, Sodiq Kamal, Budi Santosa, Tatsuo Ishijima, Toshio Nakatani, Indri Kartika Putri, N NasruddinAbstractA comparative investigation was conducted to determine the effectiveness of Manuka and Indonesian honeys to support the application of plasma jet treatment during the proliferative phase of cutaneous wound healing in 8-week-old, BALB/c male mice. The effect of honey containing different concentrations to reactive oxygen and nitrogen species (RONS) produced by plasma jet in liquid med...
Source: Clinical Plasma Medicine - August 12, 2018 Category: Research Source Type: research

Side effects in cold plasma treatment of advanced oral cancer—Clinical data and biological interpretation
ConclusionUnderstanding the lack of severe side effects in plasma medicine, the role of radical oxygen species (ROS) and radical nitrogen species (RNS) is discussed, proposing a model in which CAP is not a direct effector of antitumor action but rather triggers a singlet oxygen-mediated switch-on effect on the specific target, leading to reactivation of intercellular ROS/RNS-dependent apoptosis signaling in tumor cells. As these processes are strictly restricted to the specific targets and as normal tissue is devoid of the required target, it is neither harmed nor affected. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research

Targeting malignant melanoma with physical plasmas
Publication date: June 2018Source: Clinical Plasma Medicine, Volume 10Author(s): Gabriella Pasqual-Melo, Rajesh Kumar Gandhirajan, Ingo Stoffels, Sander BekeschusAbstractMelanoma is the deadliest form of cutaneous neoplasia. With a five-year survival rate of only 5–19%, metastatic melanoma presents severe challenges in clinical therapies. In addition, palliation is often problematic due to large numbers of fast growing metastasis. This calls for new therapeutic avenues targeting highly aggressive melanoma in palliative patients. One recently suggested innovative approach for eradication of topical tumor lesions is th...
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research

Connecting basic cold plasma technology to dermato-oncology
Publication date: June 2018Source: Clinical Plasma Medicine, Volume 10Author(s): Carsten Weishaupt, Steffen EmmertAbstractCold atmospheric plasma was intensively investigated for medical applications in the last decade and a new field of plasma medicine emerged. Basic components of cold plasma and their biomedical effects were deciphered and mainly relate to redox-biologic effects. With regard to wound treatment, cold plasma already reached standard medical care status. In terms of plasma effects in oncology, only preliminary research data are available. This emerging and highly dynamic field of plasma medicine in oncology...
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research

A myeloid and lymphoid infiltrate in murine pancreatic tumors exposed to plasma-treated medium
Publication date: Available online 7 July 2018Source: Clinical Plasma MedicineAuthor(s): Kim Rouven Liedtke, Eric Freund, Christine Hackbarth, Claus-Dieter Heidecke, Lars-Ivo Partecke, Sander BekeschusAbstractMetastatic pancreatic cancer often is fatal in patients. Palliation can include disseminating large amounts of chemotherapeutic liquid in the peritoneal cavity to slow tumor growth. We have previously demonstrated that repeated application of plasma-treated medium performed well in decreasing peritoneal tumor burden in mice and prolonging animal survival. We here extend on this study by detailed immune-related analysi...
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research

Plasma-treated medium tunes the inflammatory profile in murine bone marrow-derived macrophages
Publication date: September 2018Source: Clinical Plasma Medicine, Volume 11Author(s): Sander Bekeschus, Lukas Scherwietes, Eric Freund, Kim Rouven Liedtke, Christine Hackbarth, Thomas von Woedtke, Lars-Ivo ParteckeAbstractMacrophages are essential drivers of tumor rejection as well as tumor promotion. Especially tumor-associated macrophages (TAM) phenotypically resemble tumor-supporting alternatively activated macrophages (M2). Targeting their phenotype has long been a matter of preclinical research in oncology. Cold physical plasma and plasma-treated medium has recently been recognized as a new possible interventional str...
Source: Clinical Plasma Medicine - July 10, 2018 Category: Research Source Type: research

A myeloid and lymphoid infiltrate in murine pancreatic tumors exposed to plasma-treated medium
Publication date: Available online 7 July 2018Source: Clinical Plasma MedicineAuthor(s): Kim Rouven Liedtke, Eric Freund, Christine Hackbarth, Claus-Dieter Heidecke, Lars-Ivo Partecke, Sander BekeschusAbstractMetastatic pancreatic cancer often is fatal in patients. Palliation can include disseminating large amounts of chemotherapeutic liquid in the peritoneal cavity to slow tumor growth. We have previously demonstrated that repeated application of plasma-treated medium performed well in decreasing peritoneal tumor burden in mice and prolonging animal survival. We here extend on this study by detailed immune-related analysi...
Source: Clinical Plasma Medicine - July 8, 2018 Category: Research Source Type: research

Clinical experience with cold plasma in the treatment of locally advanced head and neck cancer
ConclusionThe trial demonstrates the clinical relevance of CAP in cancer treatment. There are three approaches for discussion of tumor remission: (i) the role of myeloid cells, (ii) the ROS/RNS model of cellular impact and (iii) the immunogenic cell death model of cancer treatment, and there is a reflection on non-sustainable tumor response due to adapted tumor microenvironment. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Cold atmospheric pressure plasma jet for the treatment of Aspergillus keratitis
ConclusionBoth in vitro and in vivo results demonstrated that CAPPJ treatment was effective in inactivating fungal pathogens and therefore it may be considered as a new treatment modality for fungal keratitis. However, further studies are required to investigate its long-term safety. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

The effect of polymeric denture modified in low-temperature glow discharge on human oral mucosa: Clinical case
Publication date: March 2018Source: Clinical Plasma Medicine, Volume 9Author(s): T. Vasilieva, Aung Myat Hein, A. Vargin, E. Kudasova, E. Kochurova, M. NekludovaAbstractThe modification hot curing poly(methyl methacrylate) (PMMA) denture base “Villacryl H Plus” in RF-discharge plasma is described The plasma chemical modification of PMMA plates in the oxygen RF-discharge (13.56 MHz) decreased the water contact angles by 1.5–2.5 times with respect to unmodified samples while their surface free energy increased up to 1.5 times due to the formation of additional oxygen containing polar chemical groups at...
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Alternative method for healing the diabetic foot by means of a plasma needle
This report presents the results of the case of an 83-year-old woman who was healed of a neuropathic ulcer after being exposed to a helium cold plasma using a plasma needle-type reactor. Along with this antecedent, we propose an alternative method consisting of the application of the helium cold plasma as an adequate option for the treatment and healing of this type of wounds. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Comparing two different plasma devices kINPen and Adtec SteriPlas regarding their molecular and cellular effects on wound healing
ConclusionsThis comparative study showed that cold atmospheric plasma has several positive effects on wound healing and that kINPen and MicroPlaSter are two devices with substantial, comparable basic research. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Permeabilization of human stratum corneum and full-thickness skin samples by a direct dielectric barrier discharge
Publication date: March 2018Source: Clinical Plasma Medicine, Volume 9Author(s): Monika Gelker, Christel C. Müller-Goymann, Wolfgang ViölAbstractA direct ex vivo treatment of human skin with cold atmospheric plasma, specifically a dielectric barrier discharge (DBD) using skin as the ground electrode, is able to permeabilize the stratum corneum (SC) throughout a treated area of 0.5 cm2. Silver sheet oxidation subsequent to a plasma treatment of isolated human SC revealed a regular pattern of local permeabilized regions greater in number than the expected number of skin appendages. The transepithelial electrical ...
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Side effects in cold plasma treatment of advanced oral cancer—Clinical data and biological interpretation
ConclusionUnderstanding the lack of severe side effects in plasma medicine, the role of radical oxygen species (ROS) and radical nitrogen species (RNS) is discussed, proposing a model in which CAP is not a direct effector of antitumor action but rather triggers a singlet oxygen-mediated switch-on effect on the specific target, leading to reactivation of intercellular ROS/RNS-dependent apoptosis signaling in tumor cells. As these processes are strictly restricted to the specific targets and as normal tissue is devoid of the required target, it is neither harmed nor affected. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Targeting malignant melanoma with physical plasmas
Publication date: June 2018Source: Clinical Plasma Medicine, Volume 10Author(s): Gabriella Pasqual-Melo, Rajesh Kumar Gandhirajan, Ingo Stoffels, Sander BekeschusAbstractMelanoma is the deadliest form of cutaneous neoplasia. With a five-year survival rate of only 5–19%, metastatic melanoma presents severe challenges in clinical therapies. In addition, palliation is often problematic due to large numbers of fast growing metastasis. This calls for new therapeutic avenues targeting highly aggressive melanoma in palliative patients. One recently suggested innovative approach for eradication of topical tumor lesions is th...
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Connecting basic cold plasma technology to dermato-oncology
Publication date: June 2018Source: Clinical Plasma Medicine, Volume 10Author(s): Carsten Weishaupt, Steffen EmmertAbstractCold atmospheric plasma was intensively investigated for medical applications in the last decade and a new field of plasma medicine emerged. Basic components of cold plasma and their biomedical effects were deciphered and mainly relate to redox-biologic effects. With regard to wound treatment, cold plasma already reached standard medical care status. In terms of plasma effects in oncology, only preliminary research data are available. This emerging and highly dynamic field of plasma medicine in oncology...
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Plasma-treated medium tunes the inflammatory profile in murine bone marrow-derived macrophages
Publication date: Available online 30 June 2018Source: Clinical Plasma MedicineAuthor(s): Sander Bekeschus, Lukas Scherwietes, Eric Freund, Kim Rouven Liedtke, Christine Hackbarth, Thomas von Woedtke, Lars-Ivo ParteckeAbstractMacrophages are essential drivers of tumor rejection as well as tumor promotion. Especially tumor-associated macrophages (TAM) phenotypically resemble tumor-supporting alternatively activated macrophages (M2). Targeting their phenotype has long been a matter of preclinical research in oncology. Cold physical plasma and plasma-treated medium has recently been recognized as a new possible interventional...
Source: Clinical Plasma Medicine - July 5, 2018 Category: Research Source Type: research

Plasma-treated medium tunes the inflammatory profile in murine bone marrow-derived macrophages
Publication date: Available online 30 June 2018 Source:Clinical Plasma Medicine Author(s): Sander Bekeschus, Lukas Scherwietes, Eric Freund, Kim Rouven Liedtke, Christine Hackbarth, Thomas von Woedtke, Lars-Ivo Partecke Macrophages are essential drivers of tumor rejection as well as tumor promotion. Especially tumor-associated macrophages (TAM) phenotypically resemble tumor-supporting alternatively activated macrophages (M2). Targeting their phenotype has long been a matter of preclinical research in oncology. Cold physical plasma and plasma-treated medium has recently been recognized as a new possible interventional stra...
Source: Clinical Plasma Medicine - June 30, 2018 Category: Research Source Type: research

Side effects in cold plasma treatment of advanced oral cancer —Clinical data and biological interpretation
Conclusion Understanding the lack of severe side effects in plasma medicine, the role of radical oxygen species (ROS) and radical nitrogen species (RNS) is discussed, proposing a model in which CAP is not a direct effector of antitumor action but rather triggers a singlet oxygen-mediated switch-on effect on the specific target, leading to reactivation of intercellular ROS/RNS-dependent apoptosis signaling in tumor cells. As these processes are strictly restricted to the specific targets and as normal tissue is devoid of the required target, it is neither harmed nor affected. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - May 11, 2018 Category: Research Source Type: research

Side effects in cold plasma treatment of advanced oral cancer – Clinical data and biological interpretation
Conclusion Understanding the lack of severe side effects in plasma medicine, the role of radical oxygen species (ROS) and radical nitrogen species (RNS) is discussed, proposing a model in which CAP is not a direct effector of antitumor action but rather triggers a singlet oxygen-mediated switch-on effect on the specific target, leading to reactivation of intercellular ROS/RNS-dependent apoptosis signaling in tumor cells. As these processes are strictly restricted to the specific targets and as normal tissue is devoid of the required target, it is neither harmed nor affected. (Source: Clinical Plasma Medicine)
Source: Clinical Plasma Medicine - April 27, 2018 Category: Research Source Type: research