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Cancer: Carcinoma
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Total 3372 results found since Jan 2013.
The HDAC inhibitor domatinostat induces type I interferon α in Merkel cell carcinoma by HES1 repression
CONCLUSION: Our results demonstrate that the direct anti-tumor effect of HDACi domatinostat on MCC cells is at least in part mediated via decreased HES1 expression allowing the induction of IFNα, which in turn causes apoptosis.PMID:37071208 | DOI:10.1007/s00432-023-04733-y
Source: Cell Research - April 18, 2023 Category: Cytology Authors: Nalini Srinivas Lina Song Kuan Cheok Lei Jan Gravemeyer Frauke Furtmann Thilo Gambichler J ürgen C Becker Ashwin Sriram Source Type: research
A functional genetic screen for metabolic proteins unveils GART and the de novo purine biosynthetic pathway as novel targets for the treatment of luminal A ER α expressing primary and metastatic invasive ductal carcinoma
In conclusion, GART inhibition by LMX or other inhibitors of the de novo purine biosynthetic pathway could be a novel effective strategy for the treatment of primary and metastatic BCs.
Source: Frontiers in Endocrinology - April 18, 2023 Category: Endocrinology Source Type: research
LIF Inhibits Proliferation of Esophageal Squamous Carcinoma Cells by Radiation Mediated Through JAK-STAT Signaling Pathway
Conclusion: The findings of this study reveal that Carbon ion knockdown was shown to downregulate LIF in ESCC cells. LIF is involved in ESCC proliferation and inhibited the ESCC cell proliferation by activating the STAT3 signaling pathways.PMID:37057285 | PMC:PMC10088534 | DOI:10.7150/jca.81222
Source: Cancer Control - April 14, 2023 Category: Cancer & Oncology Authors: Hongtao Luo Zhen Yang Qiuning Zhang Tingdong Li Ruifeng Liu Shuangwu Feng Zhiqiang Liu Shilong Sun Junru Chen Xiaohu Wang Xiaoling Xie Source Type: research
Cancers, Vol. 15, Pages 2189: THY1 (CD90) Maintains the Adherens Junctions in Nasopharyngeal Carcinoma via Inhibition of SRC Activation
In this study we show that tumor invasion could be suppressed by THY1 via adherens junction formation in a few NPC cell lines, and knockdown of THY1 would disrupt this cell-cell adhesion phenotype. Mechanistically, the activity of the SRC family kinase (SFK) member, SRC, and canonical Wnt signaling were dramatically reduced when THY1 was constitutively expressed. Previous studies by others have found that high levels of SRC activity in NPCs are associated with EMT and a poor prognosis. We hypothesized that THY1 can suppress tumor invasion in NPC via inhibition of SRC. By gene silencing of SRC, we found that the in vitro NP...
Source: Cancers - April 6, 2023 Category: Cancer & Oncology Authors: Luo Chen Wai Yin Chau Hei Tung Yuen Xiao Han Liu Robert Zhong Qi Maria Li Lung Hong Lok Lung Tags: Article Source Type: research
CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF- β/Smad/c-Myc pathway
CONCLUSION: CCT6A facilitates ESCC malignant activities by activating the TGF-β/Smad/c-Myc pathway, which sheds light on the identification of a possible therapeutic target in the management of ESCC.PMID:37017854 | DOI:10.1007/s11845-023-03357-y
Source: Cancer Control - April 5, 2023 Category: Cancer & Oncology Authors: Xiuli Xia Shushan Zhao Wenting Chen Chao Xu Dongqiang Zhao Source Type: research
Stratifin promotes the growth and proliferation of hepatocellular carcinoma
CONCLUSIONS: Our results suggest that SFN may play an important role in HCC progression and may interact with CDC25B to promote malignant progression of HCC, providing a molecular target for future HCC therapy.PMID:36996719 | DOI:10.1016/j.tice.2023.102080
Source: Tissue and Cell - March 30, 2023 Category: Cytology Authors: Xinyu Zhao Enqin Wang Hongkun Xu Lihong Zhang Source Type: research
Near-infrared fluorescence imaging of hepatocellular carcinoma cells regulated by β-catenin signaling pathway
ConclusionsOur study uncovers a mechanism that links the distribution and expression of the membrane transporters OATP2B1 and ABCG2 to the tumor-specific accumulation of MHI-148, and provides evidence supporting a regulating role of the β-catenin signaling pathway in OATP2B1 and ABCG2- induced retention of MHI-148 inHCC tissues, and strategy targeting key components of MHI-148 transport machinery may be a potential approach to improve HCC imaging.
Source: Frontiers in Oncology - March 29, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 2005: CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma
Conclusion: Targeting CDK4/6 can lead to improved efficacy when combined with radiation in OCSCC by inducing senescence and inhibiting DNA damage repair.
Source: Cancers - March 28, 2023 Category: Cancer & Oncology Authors: Nitisha Shrivastava Claudia Gutierrez Chavez Daniel Li Vikas Mehta Carlos Thomas Cory D. Fulcher Nicole Kawachi Danielle M. Bottalico Michael B. Prystowsky Indranil Basu Chandan Guha Thomas J. Ow Tags: Article Source Type: research
LncRNA RUNX1-IT1 regulating malignant pleomorphic adenoma via mir-195/CyclinD1
CONCLUSIONS: LncRNA RUNx1-IT1 may participate in the development of MPA by regulating the expression of miR-195/CyclinD1.PMID:36973850
Source: Shanghai Journal of Stomatology - March 27, 2023 Category: Dentistry Authors: Jun-Shu Wei Xin Sun Jin-Biao Xu Yi-da Chen Source Type: research
