Near-infrared fluorescence imaging of hepatocellular carcinoma cells regulated by β-catenin signaling pathway

ConclusionsOur study uncovers a mechanism that links the distribution and expression of the membrane transporters OATP2B1 and ABCG2 to the tumor-specific accumulation of MHI-148, and provides evidence supporting a regulating role of the β-catenin signaling pathway in OATP2B1 and ABCG2- induced retention of MHI-148 inHCC tissues, and strategy targeting key components of MHI-148 transport machinery may be a potential approach to improve HCC imaging.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research