The HDAC inhibitor domatinostat induces type I interferon α in Merkel cell carcinoma by HES1 repression

CONCLUSION: Our results demonstrate that the direct anti-tumor effect of HDACi domatinostat on MCC cells is at least in part mediated via decreased HES1 expression allowing the induction of IFNα, which in turn causes apoptosis.PMID:37071208 | DOI:10.1007/s00432-023-04733-y

Source: Cell Research - April 18, 2023 Category: Cytology Authors: Nalini Srinivas Lina Song Kuan Cheok Lei Jan Gravemeyer Frauke Furtmann Thilo Gambichler J ürgen C Becker Ashwin Sriram Source Type: research