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Total 3372 results found since Jan 2013.
The abrogation of GRP78 sensitizes liver cancer cells to lysionotin by enhancing ER stress-mediated pro-apoptotic pathway
Cell Stress Chaperones. 2023 Jun 16. doi: 10.1007/s12192-023-01358-5. Online ahead of print.ABSTRACTGlucose-regulated protein 78 (GRP78) is frequently and highly expressed in various human malignancies and protects cancer cells against apoptosis induced by multifarious stresses, particularly endoplasmic reticulum stress (ER stress). The inhibition of GRP78 expression or activity could enhance apoptosis induced by anti-tumor drugs or compounds. Herein, we will evaluate the efficacy of lysionotin in the treatment of human liver cancer as well as the molecular mechanism. Moreover, we will examine whether inhibition of GRP78 e...
Source: Cell Stress and Chaperones - June 16, 2023 Category: Cytology Authors: Ying Zou Hewen Shi Haiyan Lin Xiaoxue Wang Guoli Wang Yijia Gao Fan Yi Yancun Yin Defang Li Minjing Li Source Type: research
DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma
ConclusionCuproptosis and DLAT as a promising biomarker could help to determine the prognosis of HCC and may offer novel insights for effective treatment.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - June 8, 2023 Category: Research Source Type: research
MESP1-knockdown inhibits the proliferation and epithelial mesenchymal transition of hepatocellular carcinoma and enhances the tumor-suppressive effect of 5-fluorouracil
Biochem Biophys Res Commun. 2023 May 29;670:1-11. doi: 10.1016/j.bbrc.2023.05.036. Online ahead of print.ABSTRACTPrimary liver hepatocellular carcinoma (HCC) is the third most deadly malignancy worldwide,in part, because it is often diagnosed at an advanced stage. Thus, molecular markers are needed to aid in the early diagnosis and treatment of HCC. Expression of abnormal mesoderm posterior-1 (MESP1) promotes tumorigenesis; however,its role in the regulation of HCC proliferation, apoptosis,and invasion is unknown. Here,we analyzed data in The Cancer Genome Atlas (TCGA)and Genotype Tissue Expression (GTEx) databases on the ...
Source: Biochemical and Biophysical Research communications - June 4, 2023 Category: Biochemistry Authors: Shuqin Ji Man Xu Chenyu Cai Xinyue He Source Type: research
Serum Starvation Induces Matrix Metalloproteinase 9 Expression in Nasopharyngeal Carcinoma Cells Through the ERK-AP1 Pathway < em > In Vitro < /em >
CONCLUSION: Serum starvation could up-regulate MMP9 expression in NPC cells, contributing to NPC invasion. Therefore, serum starvation may promote malignancy of NPC cells but also support MMP9 as a potential therapeutic target to prevent NPC cell invasion and metastasis.PMID:37247927 | DOI:10.21873/anticanres.16425
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Yen-Ting Wu Chung-Chi Hsu Bu-Miin Huang Yun-Ching Chang Cheng-Han Lin Yu-Yan Lan Source Type: research
Remodeling Serine Synthesis and Metabolism via Nanoparticles (NPs)-Mediated CFL1 Silencing to Enhance the Sensitivity of Hepatocellular Carcinoma to Sorafenib
Adv Sci (Weinh). 2023 May 18:e2207118. doi: 10.1002/advs.202207118. Online ahead of print.ABSTRACTTyrosine kinase inhibitors represented by sorafenib are the first-line treatment for hepatocellular carcinoma (HCC), but the low response rate of HCC patient has become a clinical pain-point. Emerging evidences have revealed that metabolic reprogramming plays an important role in regulating the sensitivity of tumor cells to various chemotherapeutics including sorafenib. However, the underlying mechanisms are very complex and are not fully elucidated. By comparing the transcriptome sequencing data of sorafenib-sensitive and -in...
Source: Adv Data - May 19, 2023 Category: Epidemiology Authors: Senlin Li Lei Xu Guo Wu Ziqi Huang Linzhuo Huang Fengqian Zhang Chunfang Wei Qian Shen Rong Li Lei Zhang Xiaoding Xu Source Type: research
MiR-767-3p promotes the progression of hepatocellular carcinoma via targeting CASP-3/-9
CONCLUSION: MiR-767-3p promoted proliferation and prevented apoptosis in human hepatocellular carcinoma (HCC) through inhibiting the caspase-3/caspase-9 pathway.PMID:37193190 | PMC:PMC10182511
Source: American Journal of Translational Research - May 16, 2023 Category: Research Authors: Maolin Wu Jing Deng Dejiao Yao Shijie Li Source Type: research
