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Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023225. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in ESCC and adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) is the main upregulated transcription factor in ESCC. The results of the immunohistochemistry show that ELF4 is overexpressed in ESCC tissues and is signific...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aiping Xu Mingchuang Sun Zhaoxing Li Yuan Chu Kang Fang Yunwei Zhang Jingjing Lian Li Zhang Tao Chen Meidong Xu Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
Crosstalk between PD-L1 and Jak2-Stat3/ MAPK-AP1 signaling promotes oral cancer progression, invasion and therapy resistance
CONCLUSIONS: PD-L1 was regulated mainly by the Jak2-Stat3/ MAPK-AP1 pathway, and besides the routine immunological functions, it supports OSCC survival, invasion, and therapy resistance. PD-L1 can be used as an indicator of severity and can be targeted along with Jak2-Stat3/ MAPK-AP1 for a better outcome OSCC.PMID:37678027 | DOI:10.1016/j.intimp.2023.110894
Source: International Immunopharmacology - September 7, 2023 Category: Allergy & Immunology Authors: Arpita Jha Manzar Alam Tanushree Kashyap Nidhi Nath Anjali Kumari Kamdeo K Pramanik Siddavaram Nagini Rajakishore Mishra Source Type: research
"Squamous cell carcinoma developed in a trichilemmal cyst, an incidental finding"
Actas Dermosifiliogr. 2023 Sep 5:S0001-7310(23)00690-7. doi: 10.1016/j.ad.2023.05.032. Online ahead of print.NO ABSTRACTPMID:37678632 | DOI:10.1016/j.ad.2023.05.032
Source: Actas Dermo-Sifiliograficas - September 7, 2023 Category: Dermatology Authors: J P érez Wilson G Coulon C Whittle A Castro Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023225. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in ESCC and adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) is the main upregulated transcription factor in ESCC. The results of the immunohistochemistry show that ELF4 is overexpressed in ESCC tissues and is signific...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aiping Xu Mingchuang Sun Zhaoxing Li Yuan Chu Kang Fang Yunwei Zhang Jingjing Lian Li Zhang Tao Chen Meidong Xu Source Type: research
The level of macrophage migration inhibitory factor is negatively correlated with the efficacy of PD-1 blockade immunotherapy combined with chemotherapy as a neoadjuvant therapy for esophageal squamous cell carcinoma
CONCLUSION: Baseline MIF levels were negatively correlated with neoadjuvant therapy efficacy. Thus, MIF may serve as a predictive biomarker for this therapy. The accuracy of the prediction could be improved if the serum concentration of MIF is measured again after the patient received several weeks of treatment.PMID:37678132 | DOI:10.1016/j.tranon.2023.101775
Source: Translational Oncology - September 7, 2023 Category: Cancer & Oncology Authors: Liangliang Wu Yiming Gao Shengzhi Xie Wan Ye Yasushi Uemura Rong Zhang Yanju Yu Jinfeng Li Man Chen Qiyan Wu Pengfei Cui Hongyu Liu Shuai Mu Yilan Li Lingxiong Wang Chunxi Liu Jiahui Li Lijun Zhang Shunchang Jiao Guoqing Zhang Tianyi Liu Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
The role of microbiota in esophageal squamous cell carcinoma: A review of the literature
In conclusion, esophageal dysbiosis is associated with ESCC progression and chemoresistance. Screening the oral and esophageal microbiota is a potential diagnostic tool for predicting ESCC development or drug-resistance. Repairing esophageal dysbiosis is a novel treatment for ESCC. Clinical trials with probiotics in addition to current chemotherapy are warranted to study the therapeutic effects.
Source: Thoracic Cancer - September 7, 2023 Category: Cancer & Oncology Authors: Hsueh ‐Chien Chiang,
Michael Hughes,
Wei‐Lun Chang Tags: REVIEW Source Type: research
Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition
CONCLUSIONS: In UM patients treated with ICIs, the LDH levels were reliable indicators of prognosis.PMID:37671944 | DOI:10.18632/aging.204996
Source: Aging - September 6, 2023 Category: Biomedical Science Authors: Xiaocui Liang Shan Zhou Zefeng Xiao Source Type: research
Comprehensive analysis of P2Y family genes expression, immune characteristics, and prognosis in pan-cancer
CONCLUSION: P2Ys may be used as potential pan-cancer biomarkers in prognosis and immunology. They may also be new targets for tumor immunotherapy, which has wide clinical implications.PMID:37672858 | DOI:10.1016/j.tranon.2023.101776
Source: Translational Oncology - September 6, 2023 Category: Cancer & Oncology Authors: Chuan Liu Xiaoli Wang Siwei Wang Jiankang Xiang Huabing Xie Zongbiao Tan Xinshu Li Jixiang Zhang Weiguo Dong Source Type: research
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy
Nat Commun. 2023 Sep 6;14(1):5461. doi: 10.1038/s41467-023-41164-2.ABSTRACTThe cGAS-STING signaling pathway has emerged as a promising target for immunotherapy development. Here, we introduce a light-sensitive optogenetic device for control of the cGAS/STING signaling to conditionally modulate innate immunity, called 'light-inducible SMOC-like repeats' (LiSmore). We demonstrate that photo-activated LiSmore boosts dendritic cell (DC) maturation and antigen presentation with high spatiotemporal precision. This non-invasive approach photo-sensitizes cytotoxic T lymphocytes to engage tumor antigens, leading to a sustained anti...
Source: Cancer Control - September 6, 2023 Category: Cancer & Oncology Authors: Yaling Dou Rui Chen Siyao Liu Yi-Tsang Lee Ji Jing Xiaoxuan Liu Yuepeng Ke Rui Wang Yubin Zhou Yun Huang Source Type: research
