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A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma
Aging (Albany NY). 2023 Sep 8;15. doi: 10.18632/aging.205008. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most common subtype, accounting for about 90% of all primary liver cancers. The liver is rich in a large number of immune cells, thus forming a special immune microenvironment, which plays a key role in the occurrence and development of hepatocellular carcinoma. Nowadays, tumor immunotherapy has become one of the most promising cancer treatment methods. Immune checkpoint inhibitors (ICIs) combined with VEGF inhibitors are listed as first-line treatment options for advanced HCC. Therefore, the se...
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Tianyu Wang Kang Xia Tao Qiu Shangting Han Zhongbao Chen Xiaoxiong Ma Long Zhang Jilin Zou Yalong Zhang Bo Yu Chenyang Kong Jiayu Guo Yiting Liu Jiangqiao Zhou Shusen Zheng Source Type: research
Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using < em > Perilla frutescens < /em > Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells
In this study, we also explained the plausible mechanisms of the biosynthesis, anticancer, and antibacterial effects of PFFE-AgNPs. Overall, these findings suggest that PFFE-AgNPs have potential as a multi-functional nanomaterial for biomedical applications, particularly in cancer therapy and infection control. However, it is important to note that further research is needed to determine the safety and efficacy of these nanoparticles in vivo, as well as to explore their potential in other areas of medicine.PMID:37687260 | DOI:10.3390/molecules28176431
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Tianyu Hou Yurong Guo Wanyu Han Yang Zhou Vasudeva Reddy Netala Huizhen Li He Li Zhijun Zhang Source Type: research
Development and Validation of the Oxidative Stress Related lncRNAs for Prognosis in Esophageal Squamous Cell Carcinoma
In conclusion, our study demonstrated that a novel oxidative stress-related DElncRNA prognostic model performed favorably in predicting ESCC patient prognosis and benefits personalized clinical applications.PMID:37686677 | DOI:10.3390/cancers15174399
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Xuan Zheng Wei Liu Yingze Zhu Wenyue Kong Xin Su Lanxiang Huang Yishuang Cui Guogui Sun Source Type: research
A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma
Aging (Albany NY). 2023 Sep 8;15. doi: 10.18632/aging.205008. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most common subtype, accounting for about 90% of all primary liver cancers. The liver is rich in a large number of immune cells, thus forming a special immune microenvironment, which plays a key role in the occurrence and development of hepatocellular carcinoma. Nowadays, tumor immunotherapy has become one of the most promising cancer treatment methods. Immune checkpoint inhibitors (ICIs) combined with VEGF inhibitors are listed as first-line treatment options for advanced HCC. Therefore, the se...
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Tianyu Wang Kang Xia Tao Qiu Shangting Han Zhongbao Chen Xiaoxiong Ma Long Zhang Jilin Zou Yalong Zhang Bo Yu Chenyang Kong Jiayu Guo Yiting Liu Jiangqiao Zhou Shusen Zheng Source Type: research
The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells
Exp Eye Res. 2023 Sep 7:109647. doi: 10.1016/j.exer.2023.109647. Online ahead of print.ABSTRACTThe retinoic acid-inducible gene I (RIG)-I-like receptor (RLR) family of RNA sensor proteins plays a key role in the innate immune response to viral nucleic acids, including viral gene delivery vectors, but little is known about the expression of RLR proteins in the retina. The purpose of this study was to characterize cell-specific expression patterns of RLR proteins in non-human primate (NHP) neural retina tissue and to examine if RLR pathway signaling restricts viral gene delivery transduction. Since RLR protein signaling conv...
Source: Experimental Eye Research - September 9, 2023 Category: Opthalmology Authors: Monica M Sauter Hongyu Noel Curtis R Brandt Source Type: research
Dermoscopic Changes in Melanocytic Lesions in 368 Patients With Atypical Nevus Syndrome and Their Association With Melanoma Incidence: A Cohort Study
CONCLUSIONS: The main dermoscopic features of melanocytic lesions in patients with atypical nevus syndrome associated with progression to melanoma were grayish-white areas, asymmetric globules, asymmetric spots, and a negative pigment network.PMID:37689350 | DOI:10.1016/j.ad.2023.08.008
Source: Actas Dermo-Sifiliograficas - September 9, 2023 Category: Dermatology Authors: M I Mej ía Posada M Guti érrez Gómez E Mar ía Vásquez M A Garces Abad T Gonz ález Álvarez A M Londo ño García Source Type: research
The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells
Exp Eye Res. 2023 Sep 7:109647. doi: 10.1016/j.exer.2023.109647. Online ahead of print.ABSTRACTThe retinoic acid-inducible gene I (RIG)-I-like receptor (RLR) family of RNA sensor proteins plays a key role in the innate immune response to viral nucleic acids, including viral gene delivery vectors, but little is known about the expression of RLR proteins in the retina. The purpose of this study was to characterize cell-specific expression patterns of RLR proteins in non-human primate (NHP) neural retina tissue and to examine if RLR pathway signaling restricts viral gene delivery transduction. Since RLR protein signaling conv...
Source: Experimental Eye Research - September 9, 2023 Category: Opthalmology Authors: Monica M Sauter Hongyu Noel Curtis R Brandt Source Type: research
Dermoscopic Changes in Melanocytic Lesions in 368 Patients With Atypical Nevus Syndrome and Their Association With Melanoma Incidence: A Cohort Study
CONCLUSIONS: The main dermoscopic features of melanocytic lesions in patients with atypical nevus syndrome associated with progression to melanoma were grayish-white areas, asymmetric globules, asymmetric spots, and a negative pigment network.PMID:37689350 | DOI:10.1016/j.ad.2023.08.008
Source: Actas Dermo-Sifiliograficas - September 9, 2023 Category: Dermatology Authors: M I Mej ía Posada M Guti érrez Gómez E Mar ía Vásquez M A Garces Abad T Gonz ález Álvarez A M Londo ño García Source Type: research
Machine-Learning-Aided Prediction of Brain Metastases Development in Non-Small-Cell Lung Cancers
CONCLUSION: Analysis of the importance of input features suggests that the models are learning the relevant relationships between clinical features/development of BM. A higher number of samples is to be prioritized to improve performance. Employed prospectively at initial diagnosis, such models can help select high-risk subgroups for surveillance brain MRI.PMID:37689579 | DOI:10.1016/j.cllc.2023.08.002
Source: Clinical Lung Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Giovanni Vison à Lisa M Spiller Sophia Hahn Elke Hattingen Thomas J Vogl Gabriele Schweikert Katrin Bankov Melanie Demes Henning Reis Peter Wild Pia S Zeiner Fabian Acker Martin Sebastian Katharina J Wenger Source Type: research
The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells
Exp Eye Res. 2023 Sep 7:109647. doi: 10.1016/j.exer.2023.109647. Online ahead of print.ABSTRACTThe retinoic acid-inducible gene I (RIG)-I-like receptor (RLR) family of RNA sensor proteins plays a key role in the innate immune response to viral nucleic acids, including viral gene delivery vectors, but little is known about the expression of RLR proteins in the retina. The purpose of this study was to characterize cell-specific expression patterns of RLR proteins in non-human primate (NHP) neural retina tissue and to examine if RLR pathway signaling restricts viral gene delivery transduction. Since RLR protein signaling conv...
Source: Experimental Eye Research - September 9, 2023 Category: Opthalmology Authors: Monica M Sauter Hongyu Noel Curtis R Brandt Source Type: research
The prognostic value of lymphatic metastatic size in head and neck squamous cell carcinoma
CONCLUSIONS: Lymphatic metastatic size was an independently prognostic factor in HNSCC, which may assist in postoperative adjuvant treatment decisions.PMID:37682351 | DOI:10.1007/s00405-023-08199-z
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Wenqian Xie Peiliang Lin Zhijuan Li Huan Wan Faya Liang Jianming Fan Lanlan Deng Xiaoming Huang Source Type: research
Prevalence of human papillomavirus infection in abnormal pap smears
CONCLUSION: Our study shows that the percentage of HR-HPV-positive case increases with the severity of cytologic morphology. HPV had 4 times higher positivity in squamous intraepithelial lesion as compared to ASCUS.PMID:37681080 | PMC:PMC10481853 | DOI:10.25259/Cytojournal_8_2021
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Jaya Mishra Sweety Kalantri Vandana Raphael Biswajit Dey Yookarin Khonglah Ananya Das Source Type: research
Beta IV spectrin inhibits the metastatic growth of melanoma by suppressing VEGFR2-driven tumor angiogenesis
Cancer Med. 2023 Sep 7. doi: 10.1002/cam4.6522. Online ahead of print.ABSTRACTBACKGROUND: Tumor-associated angiogenesis mediates the growth and metastasis of most solid cancers. Targeted therapies of the VEGF pathways can effectively block these processes but often fail to provide lasting benefits due to acquired resistance and complications.RESULTS: Recently, we discovered βIV -spectrin as a powerful regulator of angiogenesis and potential new target. We previously reported that βIV -spectrin is dynamically expressed in endothelial cells (EC) to induce VEGFR2 protein turnover during development. Here, we explored how β...
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Eun-A Kwak Tasmia Ahmed Paola Cruz Flores Hannah R Ortiz Paul R Langlais Karthikeyan Mythreye Nam Y Lee Source Type: research
Clinicopathologic study of stage I adenosquamous carcinoma of the lung
CONCLUSIONS: Early-stage adenosquamous carcinoma of the lung is a histological type associated with severe prognosis and postoperative recurrence, often in distant sites, in approximately one-third of cases. High serum carcinoembryonic antigen levels and vascular invasion might be risk factors of recurrence.PMID:37681230 | DOI:10.1093/jjco/hyad122
Source: Clinical Lung Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Yoshinori Handa Takuhiro Ikeda Hideaki Hanaki Yoshihiro Miyata Hidenori Mukaida Morihito Okada Source Type: research
Combinations of EGFR and MET inhibitors reduce proliferation and invasiveness of mucosal melanoma cells
J Cell Mol Med. 2023 Sep 7. doi: 10.1111/jcmm.17935. Online ahead of print.ABSTRACTMucosal melanoma (MM) is a very rare and aggressive type of cancer for which immunotherapy or targeted therapy such as BRAF/MEK inhibitors, used in cutaneous melanoma, usually fail. Due to our earlier experience showing the high effectiveness of epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (MET) inhibitors in reducing the activation of the MAPK and PI3K/AKT signalling pathways, we aim to test whether these drugs would also be effective for mucosal melanoma. Cells representing two commercially available mucosa...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Aleksandra Simiczyjew Justyna W ądzyńska Magdalena Kot Marcin Zi ętek Rafa ł Matkowski Mai P Hoang Piotr Donizy Dorota Nowak Source Type: research
