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Personalized Biomarker-Based Umbrella Trial for Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: KCSG HN 15-16 TRIUMPH Trial
CONCLUSION: To our knowledge, this study is the first biomarker-driven umbrella trial for platinum-refractory HNSCC using matched molecular targeted agents. We found that NGS-based genomic phenotyping was methodologically feasible and applicable.PMID:37699162 | DOI:10.1200/JCO.22.02786
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Bhumsuk Keam Min Hee Hong Seong Hoon Shin Seong Gu Heo Ji Eun Kim Hee Kyung Ahn Yun-Gyoo Lee Keon-Uk Park Tak Yun Keun-Wook Lee Sung-Bae Kim Sang-Cheol Lee Min Kyoung Kim Sang Hee Cho So Yeon Oh Sang-Gon Park Shinwon Hwang Byung-Ho Nam Sangwoo Kim Hye Ryu Source Type: research
Bioinformatics analysis of CUL2/4A/9 and its function in head and neck squamous cell carcinoma
CONCLUSION: These results suggest that the transcriptional levels of CUL2/4A/9 were upregulated and these genes could affect proliferation and migration of HNSCC cells. Therefore, CUL2/4A/9 could potentially function as novel independent biomarkers in HNSCC patients.PMID:37695034 | DOI:10.5603/EP.a2023.0029
Source: Endokrynologia Polska - September 11, 2023 Category: Endocrinology Authors: Bingqing Xu Ruohuang Wang Jisheng Zhang Lin Wang Xin Cui Fangyu Chai Xiaoyun Du Yan Jiang Source Type: research
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
Bioinformatics analysis of CUL2/4A/9 and its function in head and neck squamous cell carcinoma
CONCLUSION: These results suggest that the transcriptional levels of CUL2/4A/9 were upregulated and these genes could affect proliferation and migration of HNSCC cells. Therefore, CUL2/4A/9 could potentially function as novel independent biomarkers in HNSCC patients.PMID:37695034 | DOI:10.5603/EP.a2023.0029
Source: Endokrynologia Polska - September 11, 2023 Category: Endocrinology Authors: Bingqing Xu Ruohuang Wang Jisheng Zhang Lin Wang Xin Cui Fangyu Chai Xiaoyun Du Yan Jiang Source Type: research
Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders
CONCLUSION: Our data of a pooled-analysis indicates that TP53 codon 72 polymorphism may not act as genetic factor for the risk of OPMD onset and progression. Combined with the conclusion by a systematic review and meta-analysis, we put forward a new opinion that TP53 genetic typing cloud not influence p53 protein expression in OPMD.PMID:37697274 | DOI:10.1186/s12903-023-03316-0
Source: Cancer Control - September 11, 2023 Category: Cancer & Oncology Authors: Huangkai Li Yu Liu Shanxin Zhou Qin Zhou Xi Yang Source Type: research
A pH-Activatable Nanoprobe Labels Diverse Histologic Subtypes of Human Lung Cancer During Resection
CONCLUSIONS: This translational study demonstrates the feasibility of pegsitacianine as an IMI probe to label the two most common histologic subtypes of human lung cancer.PMID:37697109 | DOI:10.1007/s11307-023-01853-2
Source: Mol Biol Cell - September 11, 2023 Category: Molecular Biology Authors: Gregory Thomas Kennedy Feredun S Azari Ashley Chang Austin Chang Patrick Bou-Samra Charuhas Desphande Edward J Delikatny Evgeniy Eruslanov John C Kucharczuk David C Rice Sunil Singhal Source Type: research
Ribosomal RNA gene downregulation in head and neck squamous carcinoma cells correlates with rDNA promoter hypermethylation
Gene. 2023 Sep 9:147793. doi: 10.1016/j.gene.2023.147793. Online ahead of print.ABSTRACTEukaryotes carry hundreds of ribosomal RNA (rRNA) genes as tandem arrays, which generate rRNA for protein synthesis. Humans carry ∼ 400 rRNA gene copies and their expression is epigenetically regulated. Dysregulation of rRNA synthesis and ribosome biogenesis are characteristic features of cancers. Targeting aberrant rRNA expression for cancer therapy is being explored. Head and neck squamous cell carcinoma (HNSCC) is among the most prevalent cancers globally. Using quantitative PCR and bisulfite sequencing, we show that rRNA genes are...
Source: Gene - September 11, 2023 Category: Genetics & Stem Cells Authors: Neha Priyadarshini Navinchandra Venkatarama Puppala Jayasree Peroth Jayaprakash Piyush Khandelia Vivek Sharma Gireesha Mohannath Source Type: research
A pH-Activatable Nanoprobe Labels Diverse Histologic Subtypes of Human Lung Cancer During Resection
CONCLUSIONS: This translational study demonstrates the feasibility of pegsitacianine as an IMI probe to label the two most common histologic subtypes of human lung cancer.PMID:37697109 | DOI:10.1007/s11307-023-01853-2
Source: Mol Biol Cell - September 11, 2023 Category: Molecular Biology Authors: Gregory Thomas Kennedy Feredun S Azari Ashley Chang Austin Chang Patrick Bou-Samra Charuhas Desphande Edward J Delikatny Evgeniy Eruslanov John C Kucharczuk David C Rice Sunil Singhal Source Type: research
Bioinformatics analysis of CUL2/4A/9 and its function in head and neck squamous cell carcinoma
CONCLUSION: These results suggest that the transcriptional levels of CUL2/4A/9 were upregulated and these genes could affect proliferation and migration of HNSCC cells. Therefore, CUL2/4A/9 could potentially function as novel independent biomarkers in HNSCC patients.PMID:37695034 | DOI:10.5603/EP.a2023.0029
Source: Endokrynologia Polska - September 11, 2023 Category: Endocrinology Authors: Bingqing Xu Ruohuang Wang Jisheng Zhang Lin Wang Xin Cui Fangyu Chai Xiaoyun Du Yan Jiang Source Type: research
PRAME/MELAN-A double immunostaining as a diagnostic tool for conjunctival melanocytic lesions: A South American experience
CONCLUSION: PRAME/MELAN-A double immunostain is particularly useful to differentiate benign from malignant conjunctival melanocytic lesions.PMID:37696245 | DOI:10.1016/j.prp.2023.154776
Source: Pathology, Research and Practice - September 11, 2023 Category: Pathology Authors: Pedro Carvajal Pablo Zoroquiain Source Type: research
Ribosomal RNA gene downregulation in head and neck squamous carcinoma cells correlates with rDNA promoter hypermethylation
Gene. 2023 Sep 9:147793. doi: 10.1016/j.gene.2023.147793. Online ahead of print.ABSTRACTEukaryotes carry hundreds of ribosomal RNA (rRNA) genes as tandem arrays, which generate rRNA for protein synthesis. Humans carry ∼ 400 rRNA gene copies and their expression is epigenetically regulated. Dysregulation of rRNA synthesis and ribosome biogenesis are characteristic features of cancers. Targeting aberrant rRNA expression for cancer therapy is being explored. Head and neck squamous cell carcinoma (HNSCC) is among the most prevalent cancers globally. Using quantitative PCR and bisulfite sequencing, we show that rRNA genes are...
Source: Gene - September 11, 2023 Category: Genetics & Stem Cells Authors: Neha Priyadarshini Navinchandra Venkatarama Puppala Jayasree Peroth Jayaprakash Piyush Khandelia Vivek Sharma Gireesha Mohannath Source Type: research
Inhibition of microRNA-15b-5p Attenuates the Progression of Oral Squamous Cell Carcinoma via Modulating the < em > PTPN4 < /em > /STAT3 Axis Retraction
Cancer Manag Res. 2023 Sep 5;15:981-982. doi: 10.2147/CMAR.S438019. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.2147/CMAR.S272498.].PMID:37693220 | PMC:PMC10492538 | DOI:10.2147/CMAR.S438019
Source: Cell Research - September 11, 2023 Category: Cytology Source Type: research
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
