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Vaccination: Influenza Vaccine

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Total 427 results found since Jan 2013.

Needle-free delivery of DNA: Targeting of hemagglutinin to MHC class II molecules protects rhesus macaques against H1N1 influenza.
Abstract Conventional influenza vaccines are hampered by slow and limited production capabilities, whereas DNA vaccines can be rapidly produced for global coverage in the event of an emerging pandemic. However, a drawback of DNA vaccines is their generally low immunogenicity in non-human primates and humans. We have previously demonstrated that targeting of influenza hemagglutinin to human HLA class II molecules can increase antibody responses in larger animals such as ferrets and pigs. Here, we extend these observations by immunizing non-human primates (rhesus macaques) with a DNA vaccine encoding a bivalent fusi...
Source: Vaccine - January 9, 2019 Category: Allergy & Immunology Authors: Mooij P, Grødeland G, Koopman G, Andersen TK, Mortier D, Nieuwenhuis IG, Verschoor EJ, Fagrouch Z, Bogers WM, Bogen B Tags: Vaccine Source Type: research

Distinguishing between Orbital and Preseptal Cellulitis
​Some medical conditions have signs and symptoms that significantly overlap, making a diagnosis a little more difficult. Epididymitis, testicular torsion, and torsion of the testicular appendage are examples, but orbital and preseptal cellulitis are others that can cause significant diagnostic confusion.Both conditions are more common in children than in adults, and preseptal or periorbital cellulitis is more common in children under 5. The preseptal and orbital spaces are separated by only a thin membranous septum that originates in the orbital periosteum and inserts into the tarsal plates. It is only this thin septum t...
Source: M2E Too! Mellick's Multimedia EduBlog - December 31, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Safety assessment of seasonal trivalent influenza vaccine produced by Instituto Butantan from 2013 to 2017.
Abstract Vaccination has been a successful strategy in influenza prevention. However, despite the safety and efficacy of the vaccines, they can cause adverse events following immunization (AEFI). Moreover, due to the vaccination success, most of vaccine-preventable diseases (VPD) have become rare, and public attention has been shifted from VPD to the AEFI associated with vaccination. This manuscript describes the safety of Instituto Butantan (IB) seasonal trivalent influenza vaccine (TIV) from 2013 to 2017. AEFI data were received by the Department of Pharmacovigilance of IB (PV-IB), from January the 1st 2013 to D...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - December 20, 2018 Category: Tropical Medicine Authors: Gattás VL, Braga PE, Koike ME, Lucchesi MBB, Oliveira MMM, Piorelli RO, Queiroz V, Precioso AR Tags: Rev Inst Med Trop Sao Paulo Source Type: research

What Is This International Traveler's Diagnosis?
​BY GREGORY TAYLOR, DO; DAWN ZELENKA-JOSHOWITZ, DO; & ANDREW TAECKER, DOA 34-year-old man presented with intermittent fever and body aches for 10 days. He had been visiting family in India, and the symptoms began when he returned home. His fever had been as high as 104°F, and he was experiencing nausea, two episodes of bilious emesis, body aches, nonspecific abdominal pain, and multiple episodes of watery, nonbloody diarrhea.He said he knew of no tuberculosis exposure or ill contacts, and he was current on his routine influenza and hepatitis A vaccines. His temperature was 101.4°F (he had taken acetaminophen three ...
Source: The Case Files - December 12, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Novel imiquimod nanovesicles for topical vaccination
Publication date: 1 February 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 174Author(s): Ayelen Tatiana Caimi, Maria Julia Altube, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Ana Paula Perez, Eder Lilia Romero, Maria Jose MorillaAbstractDevelopment of needle and pain free noninvasive immunization procedures is a top priority for public health agencies. In this work the topical adjuvant activity of the immunomodulator imiquimod (IMQ) carried by ultradeformable archaeosomes (UDA2) (nanovesicles containing sn-2,3 ether linked phytanyl saturated archaeolipids) was surveyed and compared with that of ult...
Source: Colloids and Surfaces B: Biointerfaces - November 28, 2018 Category: Biochemistry Source Type: research

Racial Disparities in the Utilization of Recommended Supportive Care Among Patients with Multiple Myeloma in the United States
Conclusion: We found significant under-utilization of supportive care measures focused at bone health and infection prevention among elderly adults with MM in the US. Similar to prior work evaluating utilization of novel MM therapies and transplantation, we found significant racial disparities in receipt of MM supportive care. Future studies should seek to identify reasons for such under-utilization of supportive care during MM therapy so that appropriate interventions may be implemented.DisclosuresZeidan: Agios: Consultancy; Celgene: Consultancy; Novartis: Consultancy; Incyte: Employment; Gilead: Consultancy; Ariad: Consu...
Source: Blood - November 21, 2018 Category: Hematology Authors: Giri, S., Zhu, W., Wang, R., Zeidan, A. M., Podoltsev, N. A., Gore, S. D., Ma, X., Davidoff, A. J., Huntington, S. F. Tags: 902. Health Services Research-Malignant Diseases: Quality Of Life Studies Source Type: research

Quality of Care Indicators in Patients with Sickle Cell Disease (SCD): Influenza Vaccination and Routine Eye Examination Are Associated with Outpatient Utilization but Not Acute Hospital Care, Whereas Comorbidity Indexes Are Strongly Associated with Both
In conclusion, outpatient-based candidate quality indicators of care examined (influenza vaccination and eye examination), were associated with increased outpatient utilization, but not acute visits or hospitalizations. Co-morbidity indexes have significant confounding effects on outpatient and hospital utilization. Administrative data based quality indicators of care such as influenza vaccination, as well as SCD specific comorbidity indexes warrant further studies as these may help better understand optimal allocation of health care resources for patients with SCD.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Adamkiewicz, T., Baltrus, P., Li, C., Carter-Wicker, K., Gaglioti, A. Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster II Source Type: research

What is the Recurrence Rate for Guillian-Barr é Syndrome and Should She Get An Influenza Vaccine?
Discussion Guillian-Barré syndrome (GBS) is an acquired, acute, inflammatory, demyelinating polyneuropathy. It is the most common cause of acute and subacute flaccid paralysis in children. GBS causes about 0.4-1.3 cases per 100,000 persons/year in children. It can occur in any age group and the incidence increases among all age groups until a peak in the 50s. Both genders are affected and there may be a slight increase in males. GBS usually occurs 2-4 weeks after a prodromal gastroenteritis or respiratory illness. GBS causes autoantibody production against Schwann cells of the neuron and the axon itself. There is ...
Source: PediatricEducation.org - November 19, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Late Breaking Abstract - Safety and immunogenicity of non-typeable H. influenzae (NTHi) and M. catarrhalis (Mcat) adjuvanted vaccines in adults
Conclusion: NTHi-Mcat vaccines have an acceptable reactogenicity/safety profile and are immunogenic.Funding: GlaxoSmithKline Biologicals SA
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Van Damme, P., Leroux-Roels, G., Vandermeulen, C., De Ryck, I., Tasciotti, A., Dozot, M., Moraschini, L., Testa, M., Arora, A. K. Tags: Clinical Problems Source Type: research

Late Breaking Abstract - Safety and immunogenicity of non-typeable H. influenzae (NTHi) adjuvanted vaccine in older adults with chronic obstructive pulmonary disease (COPD)
Conclusion: NTHi vaccine has an acceptable safety profile, induces substantial increases in humoral responses and moderate CD4+ T-cell responses.Funding: GlaxoSmithKline Biologicals SA
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wilkinson, T., Schembri, S., Brightling, C., Bakerly, N. D., Macnee, W., Rombo, L., Hedner, J., Allen, M., Walker, P., De Ryck, I., Tasciotti, A., Casula, D., Testa, M., Arora, A. K. Tags: Clinical Problems Source Type: research

Influencing Vaccinations: A Buzzy Approach to Ease the Discomfort of a Needle Stick —a Prospective, Randomized Controlled Trial
The rate of annual influenza immunization in both the general public and health care workers is less than desirable. Mechanisms to improve compliance with recommendations are needed; prevention of immunization site pain has been suggested as a viable route because fear of pain and needles has been cited as a barrier.
Source: Pain Management Nursing - November 10, 2018 Category: Nursing Authors: Roberta E. Redfern, Jennifer Micham, Sara Seegert, John T. Chen Tags: Original Article Source Type: research

A 19-year old man with IgA vasculitis after vaccination
Publication date: Available online 30 October 2018Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Alexandre Malek, Sara Isabel Gomez-Villegas, Alejandro de la Hoz, Cima Nowbakht, Cesar A. AriasAbstractA 19-year-old patient who mistakenly received two doses of influenza vaccine 10 days before presentation, was admitted with malaise, weakness, and a purpuric non-blanching rash most prominent on the ankles followed by abdominal pain and hematochezia 72 h later. The diagnosis of influenza vaccine-related Henoch–Schonlein vasculitis was made. This complication, although rare, is the most common vasculitis ...
Source: The Brazilian Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Source Type: research

A 19-year old man with IgA vasculitis after vaccination.
Abstract A 19-year-old patient who mistakenly received two doses of influenza vaccine 10 days before presentation, was admitted with malaise, weakness, and a purpuric non-blanching rash most prominent on the ankles followed by abdominal pain and hematochezia 72h later. The diagnosis of influenza vaccine-related Henoch-Schonlein vasculitis was made. This complication, although rare, is the most common vasculitis related to immunization. PMID: 30389353 [PubMed - as supplied by publisher]
Source: Braz J Infect Dis - October 30, 2018 Category: Infectious Diseases Authors: Malek A, Gomez-Villegas SI, de la Hoz A, Nowbakht C, Arias CA Tags: Braz J Infect Dis Source Type: research

A phase III, open-label, single-arm, study to evaluate the safety and immunogenicity of a trivalent, surface antigen inactivated subunit influenza virus vaccine produced in mammalian cell culture (Optaflu ®) in healthy adults
AbstractVaccination is an essential tool in reducing the impact of seasonal influenza infections. The viral strains responsible for seasonal outbreaks vary annually, and preventive vaccines have to be adapted accordingly. The aim of this study was to evaluate the safety, clinical tolerability and the antibody response to each of the three influenza vaccine antigens after vaccination with a cell-derived, trivalent, surface antigen, inactivated influenza vaccine (TIVc), as measured by single radial haemolysis (SRH) or haemagglutination inhibition (HI) assay in accordance with European Union licensing guidelines in place for ...
Source: Infection - October 8, 2018 Category: Infectious Diseases Source Type: research

The effect of exercise on local and systemic adverse reactions after vaccinations - Outcomes of two randomized controlled trials.
DISCUSSION: In two separate trials, a short bout of exercise reduced reported adverse reactions after vaccinations for local and systemic adverse reactions. Gender differences in reported local and systemic adverse reactions were more evident among adolescents than young adults. These findings support the need for further work to examine the potential benefit of exercise in improving vaccination procedures. PMID: 30301642 [PubMed - as supplied by publisher]
Source: Vaccine - October 6, 2018 Category: Allergy & Immunology Authors: Lee VY, Booy R, Skinner SR, Fong J, Edwards KM Tags: Vaccine Source Type: research