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Efficient elimination of phenazone by an electro-assisted Fe < sup > 3+ < /sup > -EDDS/PS process at neutral pH: Kinetics, mechanistic insights and toxicity evaluation
Chemosphere. 2023 Apr 5:138598. doi: 10.1016/j.chemosphere.2023.138598. Online ahead of print.ABSTRACTThe feasibility of the degradation of phenazone (PNZ), a common anti-inflammatory drug used for reducing pain and fever, in water at neutral pH by an electrochemically assisted Fe3+-ethylenediamine disuccinate-activated persulfate process (EC/Fe3+-EDDS/PS) was investigated. The efficient removal of PNZ at neutral pH condition was mainly attributed to the continuous activation of PS via electrochemically driven regenerated Fe2+ from a Fe3+-EDDS complex at the cathode. The influence of several critical parameters, including ...
Source: Chemosphere - April 7, 2023 Category: Chemistry Authors: Yuqiong Gao Han Ning Yanyan Rao Kexuan Li Chaole Zeng Naiyun Gao Source Type: research

Molecules, Vol. 28, Pages 3206: Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion
VanWert Oxalate is a divalent organic anion that affects many biological and commercial processes. It is derived from plant sources, such as spinach, rhubarb, tea, cacao, nuts, and beans, and therefore is commonly found in raw or processed food products. Oxalate can also be made endogenously by humans and other mammals as a byproduct of hepatic enzymatic reactions. It is theorized that plants use oxalate to store calcium and protect against herbivory. Clinically, oxalate is best known to be a major component of kidney stones, which commonly contain calcium oxalate crystals. Oxalate can induce an inflammatory response t...
Source: Molecules - April 4, 2023 Category: Chemistry Authors: Bryan Misiewicz Donald Mencer William Terzaghi Adam L. VanWert Tags: Review Source Type: research

α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms
In conclusion, glial α7 nAChR stimulation/potentiation downregulates neuroinflammatory targets, and thereby remains a promising therapeutic option for cancer chemotherapy-induced neuroinflammation and neuropathic pain.PMID:36966906 | DOI:10.1016/j.biocel.2023.106405
Source: The International Journal of Biochemistry and Cell Biology - March 26, 2023 Category: Biochemistry Authors: Ilias Marmouzi Stephanie Myers Daniel J Buck Randall L Davis Hugo R Arias Source Type: research

A Link Between Inflammatory Mechanisms and Fibromyalgia
Adv Exp Med Biol. 2023;1411:357-378. doi: 10.1007/978-981-19-7376-5_16.ABSTRACTFibromyalgia (FM) is a condition characterized by chronic widespread pain, which has traditionally been considered psychogenic in nature due to lack of known underlying organic pathophysiology. In more recent years, inflammation of the nervous system has become increasingly recognized as a sign of neuropsychiatric conditions, and this association may enhance our knowledge of conditions such as FM. Emerging evidence has suggested inflammation, particularly neuroinflammation, as a potential contributor underlying the etiology of FM. Studies have s...
Source: Advances in Experimental Medicine and Biology - March 23, 2023 Category: Research Authors: Ashika Bains Samuel Kohrman Diana Punko Gregory Fricchione Source Type: research

Positive Schemas, Coping, and Quality of Life in Pediatric Recurrent Abdominal Pain
AbstractPediatric recurrent abdominal pain is commonly associated with negative impacts on quality of life (QOL). Positive schemas (core beliefs about the self with subthemes of self-efficacy, optimism, trust, success, and worthiness) are a resilience factor that has not yet been examined within a pediatric recurrent pain context. This cross-sectional study examined (a) associations between positive schemas, pain coping, and youth QOL, and (b) exploratory analyses to investigate whether specific positive schema subthemes predicted QOL outcomes in youth with recurrent abdominal pain. Participants were 98 youth with recurren...
Source: Journal of Clinical Psychology in Medical Settings - March 23, 2023 Category: Psychiatry & Psychology Source Type: research

Sensing interface based on electrodeposited Cu-BTC microporous film for electrochemical detection of pain killer paracetamol
Analyst, 2023, Accepted Manuscript DOI: 10.1039/D3AN00110E, PaperThu Thi Vu, Tien Dat Nguyen, Ngoc Tien Nguyen, Nguyen Thi Thanh Ngan The use of metal-organic framework materials in electrochemical sensors are gaining more attention in last few years due to their highly porous structure and electrocatalytic activity. In this work, a... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - March 9, 2023 Category: Chemistry Authors: Thu Thi Vu Source Type: research

Evaluation and Management of the Dysesthetic Patient
Dysesthesia is symptomatology that includes, but is not limited to, sensations of pain, burning, crawling, biting, numbness, piercing, pulling, cold, shock-like, pulling, wetness, and heat. These sensations can cause significant emotional distress and functional impairment in affected individuals. While some cases of dysesthesias are secondary to organic etiologies, most cases exist without an identifiable infectious, inflammatory, autoimmune, metabolic, or neoplastic process. Ongoing vigilance is required for concurrent or evolving processes, including paraneoplastic presentations.
Source: Clinics in Dermatology - March 4, 2023 Category: Dermatology Authors: Alexis Holmes, Richard Fried Source Type: research

The role and regulation mechanism of Chinese traditional fitness exercises on the bone and cartilage tissue in patients with osteoporosis: A narrative review
Osteoporosis (ops) is a systemic degenerative bone disease characterized by bone mass reduction, bone mineral density loss, bone microstructure destruction, bone fragility, and increased fracture susceptibility. Thus far, drug therapy is the main method used to prevent and treat osteoporosis. However, long-term drug treatment will inevitably lead to drug resistance and certain side effects. In response, rehabilitation treatment is generally recommended, which involves drug supplementation combined with the treatment. A Chinese traditional fitness exercise is an organic combination of sports and traditional Chinese medicine...
Source: Frontiers in Physiology - February 28, 2023 Category: Physiology Source Type: research

What is PAN?
Discussion Vasculitis is an inflammation of the blood vessels. Often, the term implies the arterial vessels, but venous and capillary vessels can be affected. The nomenclature to describe vasculitis and its classification have varied over time. Arterial vessel size is one method and some more common entities include: Small vessel, mainly Granulomatous – granulomatosis with polyangiitis (aka Wegener’s granulomatosis), eosinophilic granulomatosis with polyangiitis (aka Churg Strauss syndrome) Nongranulomatous – Henoch-Schonlein purpura (HSP), microscopic polyangiitis Medium vessel, mainly Childhood sys...
Source: PediatricEducation.org - February 27, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Trichobezoar-A rare cause of hyperemesis in a pregnant woman
We present a case of young pregnant women who was admitted on few occasions with vomiting in early pregnancy and was treated as hyperemesis gravidarum. Failure of response to conventional management prompted further investigation, revealing trichobezoar. Our case highlights the diagnostic challenge posed by trichobezoars in young pregnant women.PMID:36842899 | DOI:10.1016/j.ejogrb.2023.02.007
Source: Reproductive Biology - February 26, 2023 Category: Reproduction Medicine Authors: Sunitha Ramaiah Spyridon Bekas Thangamma-Katimada Annaiah Source Type: research