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Total 147 results found since Jan 2013.

Anti-SRP Myopathy with Sensorimotor Polyneuropathy: A Case Report
CONCLUSION: Anti-SRP myopathy can present with sensorimotor polyneuropathy. Thus, the possibility that the same pathological process affected the skeletal muscles and peripheral nerves should be considered.PMID:37723914
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Lei-Ying Huang Yi-Jen Peng Yueh-Feng Sung Source Type: research

Immune ‐mediated necrotizing myopathy with concomitant development of Kikuchi–Fujimoto disease
AbstractImmune-mediated necrotizing myopathy (IMNM) is a distinct type of idiopathic inflammatory myositis, pathologically characterized by myofiber necrosis and degeneration in the absence of lymphocyte infiltration. Herein, we present a case of IMNM with concomitant development of Kikuchi –Fujimoto disease (KFD), characterized by histiocytic necrotizing lymphadenitis, in a 36-year-old woman who had a treatment history for rheumatoid arthritis (RA). Treatment with oral prednisolone and tacrolimus as immunosuppressants resulted in the remission of the skeletomuscular involvement and lymphadenopathy. To the best of our kn...
Source: International Journal of Rheumatic Diseases - September 1, 2023 Category: Rheumatology Authors: Takanori Ichikawa, Ryo Furukawa, Yasuhiro Shimojima, Yumi Hoshino, Dai Kishida, Yoshiki Sekijima Tags: CASE REPORT Source Type: research

Single fibre cytoarchitecture in ventilator-induced diaphragm dysfunction (VIDD) assessed by quantitative morphometry second harmonic generation imaging: Positive effects of BGP-15 chaperone co-inducer and VBP-15 dissociative corticosteroid treatment
Ventilator-induced diaphragm dysfunction (VIDD) is a common sequela of intensive care unit (ICU) treatment requiring mechanical ventilation (MV) and neuromuscular blockade (NMBA). It is characterised by diaphragm weakness, prolonged respirator weaning and adverse outcomes. Dissociative glucocorticoids (e.g., vamorolone, VBP-15) and chaperone co-inducers (e.g., BGP-15) previously showed positive effects in an ICU-rat model. In limb muscle critical illness myopathy, preferential myosin loss prevails, while myofibrillar protein post-translational modifications are more dominant in VIDD. It is not known whether the marked decl...
Source: Frontiers in Physiology - June 27, 2023 Category: Physiology Source Type: research

Challenges in the diagnosis and management of immune-mediated necrotising myopathy (IMNM) in a patient on long-term statins
We present a case report and brief review of the literature regarding the pathogenesis, diagnosis, and management of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) positive IMNM (HMGCR IMNM). There are no randomised clinical trials, but several smaller studies and cases suggest a triple therapy of corticosteroids, IVIG, and a corticosteroid-sparing immunosuppressant appears efficacious in patients with IMNM and proximal weakness. The mechanism of statin-induced IMNM is uncertain, and this is further complicated by the reports of HMGCR IMNM in statin-na ïve patients, including children. We present a case of b...
Source: Rheumatology International - February 1, 2023 Category: Rheumatology Source Type: research

Proximal muscle weakness as the sole manifestation of Cushing ’s disease, misdiagnosed as dermatomyositis: a case report
ConclusionThis case report emphasizes the high diagnostic importance of proximal muscle weakness as the sole presenting manifestation of Cushing ’s syndrome/disease.
Source: Journal of Medical Case Reports - December 22, 2022 Category: General Medicine Source Type: research

New-onset dermatomyositis following COVID-19: A case report
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Most of the infected individuals have recovered without complications, but a few patients develop multiple organ involvements. Previous reports suggest an association between COVID-19 and various inflammatory myopathies, in addition to autoimmune diseases. COVID-19 has been known to exacerbate preexisting autoimmune diseases and trigger various autoantibodies and autoimmune disease occurrence. Here we report a case of complicated COVID-19 with anti-synthetase autoantibodies (ASSs) presenting ...
Source: Frontiers in Immunology - October 24, 2022 Category: Allergy & Immunology Source Type: research

A Case of Autoimmune Pulmonary Alveolar Proteinosis During the Treatment of Idiopathic Inflammatory Myopathy
Intern Med. 2022 Jul 14. doi: 10.2169/internalmedicine.9558-22. Online ahead of print.ABSTRACTApproximately 50% of idiopathic inflammatory myopathies (IIMs) are associated with interstitial lung disease (ILD). Typically, IIM-ILD manifests as nonspecific interstitial pneumonia. We herein report a rare case of a 78-year-old man with autoimmune pulmonary alveolar proteinosis (PAP) that developed during IIM treatment. The diagnosis of autoimmune PAP was based on detecting anti-granulocyte-macrophage colony-stimulating factor antibodies. We postulated that PAP may have been induced by IIM treatment with prednisolone. Our case s...
Source: Internal Medicine - July 13, 2022 Category: Internal Medicine Authors: Naoki Shijubou Takeyuki Sawai Taku Hatakeyama Satoru Munakata Masami Yamazoe Hirofumi Chiba Source Type: research

Case Report: Hereditary Fibrosing Poikiloderma With Tendon Contractures, Myopathy, and Pulmonary Fibrosis (POIKTMP) Presenting With Liver Cirrhosis and Steroid-Responsive Interstitial Pneumonia
Conclusions: We report a case of POIKTMP in which interstitial pneumonia was improved by corticosteroids, suggesting that corticosteroids could be an option for the treatment of interstitial pneumonia associated with this disease.
Source: Frontiers in Genetics - May 5, 2022 Category: Genetics & Stem Cells Source Type: research