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Total 147 results found since Jan 2013.

Antimitochondrial Antibody-associated Myopathy with Slowly Progressive Cardiac Dysfunction: A Case Report.
Authors: Takahashi F, Sawada J, Minoshima A, Sakamoto N, Ono T, Akasaka K, Takei H, Nishino I, Hasebe N Abstract A 45-year-old woman was referred to our hospital for the evaluation of proximal muscle weakness and serum creatinine kinase elevation. She had atrial fibrillation and left ventricular asynergy. She was diagnosed with myopathy, accompanied by cardiomyopathy of unknown etiology. She was treated with prednisolone. After long-term follow-up and a detailed examination, the patient was diagnosed with antimitochondrial antibody (AMA)-associated myopathy with cardiac involvement. Although the patient received me...
Source: Internal Medicine - October 30, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Resection of Gastric Cancer Remitted Anti-signal Recognition Particle Myopathy
Intern Med. 2022 Feb 1. doi: 10.2169/internalmedicine.9055-21. Online ahead of print.ABSTRACTA 72-year-old woman presented with gradually-worsening myalgia and muscle weakness of the proximal lower limbs as well as elevated serum creatine kinase level. Based on a clinicoseropathological examination including a muscle biopsy, she was diagnosed with anti-signal recognition particle (SRP) myopathy. Although the myopathy relapsed two times in two years under oral prednisolone and intravenous immunoglobulin therapy, the myopathy remained in remission for more than three years after resection of gastric cancer. Although the anti...
Source: Internal Medicine - February 3, 2022 Category: Internal Medicine Authors: Yoshihide Sehara Kyoichiro Tsuchiya Ichizo Nishino Hirotake Sato Yoshihito Ando Source Type: research

Anti-SRP Myopathy with Sensorimotor Polyneuropathy: A Case Report
CONCLUSION: Anti-SRP myopathy can present with sensorimotor polyneuropathy. Thus, the possibility that the same pathological process affected the skeletal muscles and peripheral nerves should be considered.PMID:37723914
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Lei-Ying Huang Yi-Jen Peng Yueh-Feng Sung Source Type: research

Paraneoplastic Anti-3-hydroxy-3-methylglutary-coenzyme A Reductase Antibody-positive Immune-mediated Necrotizing Myopathy in a Patient with Uterine Cancer.
We report the case of a 69-year-old woman with proximal limb muscle weakness, who received post-operative chemotherapy for uterine cancer. Her serum creatinine kinase level was high (10,779 mg/dL) and a muscle biopsy from her left biceps revealed various sizes of muscle fibers accompanied by necrotic and regenerating fibers. She was positive for anti-3 hydroxy-3-methylglutary-coenzyme A reductase (anti-HMGCR) antibodies, but negative for anti-signal recognition particle (anti-SRP) antibodies. She was diagnosed with immune-mediated necrotizing myopathy (IMNM) and treated with prednisolone. Our findings indicate that not onl...
Source: Internal Medicine - July 20, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

G.P.75: A rare inflammatory myopathy with cytochrome oxidase negative muscle fiber patient which presents in chidhood: Case report
We describe a 10-year old girl with progressive lower limb weakness and myalgia. With increased serum muscle enzymes, erythrocyte sedimentation rate, proximal muscle weakness, and EMG findings, she was considered as an inflammatory myopathy. Oral prednisolone (2mg/kg/day) treatment was started. During clinical observation patient showed no response to treatment and muscle biopsy was performed. Muscle biopsy showed COX-negative fibers without discrete inflammatory infiltrates and necrotizing features. Mitochondrial DNA analysis did not reveal any mutation. The patient was diagnosed as “inflammatory myopathy with COX negat...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: G. Diniz, O. Yavascan, Z. Yildirim, B. Sarkis, C. Alparslan, C. Ozturk Source Type: research

Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody.
Authors: Kusumoto T, Okamori S, Masuzawa K, Asakura T, Nishina N, Chubachi S, Naoki K, Fukunaga K, Betsuyaku T Abstract A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year later, anti-signal recognition particle (SRP) antibody was confirmed and he was re-admitted for hypoxemia with elevated CK. MRI revealed muscle edema and a histopathological examination of a muscle biops...
Source: Internal Medicine - March 3, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Sarcoid Orbital Myopathy: Clinical Presentation and Outcomes
Conclusions: This study presents the long-term results of patients with sarcoid-related orbital myopathy and systemic disease may be found in over 80% of newly diagnosed cases. The superior rectus/levator complex and lateral rectus are most commonly involved—possibly due to spill-over inflammation from granulomatous dacryoadenitis. Approximately two-thirds of cases respond well to systemic corticosteroids, while one-third develop recurrent disease. Sarcoid orbital myopathy is rare and mainly affects the superior rectus/levator complex and lateral rectus, possibly due to neighboring dacryoadenitis. Most settle with sys...
Source: Ophthalmic Plastic and Reconstructive Surgery - January 1, 2020 Category: Opthalmology Tags: Original Investigations Source Type: research

Juvenile Idiopathic Inflammatory Myopathy in a Patient With Dyskeratosis Congenita Due to C16orf57 Mutation
Dyskeratosis congenita (DC) is a rare inherited disorder characterized by reticular skin pigmentation, oral cavity leukoplakia, and nail dystrophy. A variety of noncutaneous (dental, pulmonary, gastrointestinal, neurological, genitourinary, ophthalmic, and skeletal) abnormalities also have been reported. An 8-year-old boy with DC developed juvenile idiopathic inflammatory myopathy. C16orf57 mutation was identified as a genetic cause of DC. Treatment with methylprednisolone was initiated, followed with methotrexate, prednisolone, and high-dose intravenous immunoglobulin treatment. This is the first report on a patient with ...
Source: Journal of Pediatric Hematology Oncology - February 19, 2016 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

P035  Inflammatory myopathy and metabolic disorders causing myopathies
Conclusion This lady was initially managed as inflammatory myopathy but did not respond to high dose methylprednisolone. There were atypical features including normal inflammatory markers, MRI thighs showing predominantly fatty infiltration and muscle atrophy and the muscle biopsy with abundant lipid accumu lation suggestive of a metabolic disorder. We are awaiting full results of genetic testing. This case is a reminder of the importance of tissue diagnosis and reassessing the initial diagnosis if the clinical picture changes or patients do not respond as expected to treatment.Disclosure M. Malik: None.A. Mason: None....
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research