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Total 48 results found since Jan 2013.

A Case of Statin-Associated Autoimmune Myopathy: Management and Treatment
We present a case of a male patient who developed progressively worsening muscle weakness and elevated muscle enzyme markers upon initiation of a statin. His symptoms persisted despite a trial of an alternative statin and subsequent discontinuation of all statin medications. A multitude of possible etiologies were considered and ranged from infectious, autoimmune, cancerous, to congenital in nature. Environmental factors, such as exposure to medications or toxins, were also considered as one of the possible precipitating factors. The association between his statin consumption and muscle weakness were not easily apparent at...
Source: Primary Care - January 23, 2023 Category: Primary Care Authors: Mercedes Malone Abdelilah Lahmar Atif Siddique Michael Rozboril Jesse L Kresak Source Type: research

Life-Long Steroid Responsive Familial Myopathy With Docking Protein 7 Mutation
Docking protein 7 (DOK7) congenital myasthenic syndrome (CMS) is characterized by limb-girdle weakness and lack of fluctuating fatigability simulating many familial myopathies. Albuterol is the first line of therapy in view of consistent improvement. Two brothers with progressive predominant biceps weakness for 1–3 years responded to prednisone treatment for 40–50 years. Various studies including muscle biopsy and many laboratory studies were unsuccessful for the definite diagnosis. Gene study, 40 years after the initial evaluation, confirmed the diagnosis of DOK7 CMS. These are the first reported cases of DOK7 CMS ass...
Source: Journal of Clinical Neuromuscular Disease - November 24, 2022 Category: Neurology Tags: Case Reviews Source Type: research

Clinicopathologic Profiles of Sporadic Late-Onset Nemaline Myopathy: Practical Importance of Anti-{alpha}-Actinin Immunostaining
Discussion SLONM is a treatable myopathy with ASCT or traditional immunotherapy, especially when combined with steroids and immunosuppressants. Anti–α-actinin immunostaining is the most reliable pathologic marker to identify rod-bearing fibers, and it should be performed routinely in adult patients with undiagnosed nonnecrotic myopathies.
Source: Neurology Neuroimmunology and Neuroinflammation - May 17, 2022 Category: Neurology Authors: Zhao, B., Dai, T., Zhao, D., Ma, X., Zhao, C., Li, L., Sun, Y., Zhang, Y., Yan, Y., Lu, J.-Q., Liu, F., Yan, C. Tags: MRI, All Immunology, Autoimmune diseases, All Clinical Neurology, Muscle disease Research Article Source Type: research

Role of Intravenous Immunoglobulin in Necrotizing Autoimmune Myopathy
Conclusions Based on objective, meaningful improvement in MMT-8 and CK as well as marked reduction in prednisone doses with acceptable tolerability, early implementation of IVIg should be considered in adult IMNM.
Source: JCR: Journal of Clinical Rheumatology - February 22, 2022 Category: Rheumatology Tags: Original Articles Source Type: research

Thymoma may explain the confusion: a case report
ConclusionThis case illustrates an exceptional association of two entities and the difficulty encountered during their diagnosis and treatment. The management of these two diseases is different, so it is essential to recognize this concomitant presentation.
Source: Journal of Medical Case Reports - December 16, 2021 Category: General Medicine Source Type: research

Statin-Induced Autoimmune Necrotizing Myopathy
J Prim Care Community Health. 2021 Jan-Dec;12:21501327211028714. doi: 10.1177/21501327211028714.ABSTRACTStatin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvast...
Source: Primary Care - July 5, 2021 Category: Primary Care Authors: Sahani Jayatilaka Kunal Desai Swarup Rijal Debra Zimmerman Source Type: research

Anti-HMGCR myopathy overlaps with dermatomyositis-like rash: a distinct subtype of idiopathic inflammatory myopathy
ConclusionsOptimization of cutoff of anti-HMGCR antibody assays with confirmation by alternative assays can result in higher sensitivity and specificity. DM-like skin rashes and lymphocytic infiltrates were not rare in patients with anti-HMGCR myopathy. These findings suggest that while anti-HMGCR myopathy may overlap with DM-like rash, it is pathologically different from classic DM, and should be considered a distinct subgroup of IIM.
Source: Journal of Neurology - May 21, 2021 Category: Neurology Source Type: research

Interstitial Lung Disease and Myositis in a Patient With Antisynthetase Syndrome and PL12 and Ro52 Co-positivity in a Retired Medical Officer.
Authors: Loncharich MF, Anderson CW, Collins J, Edison J Abstract Antisynthetase syndrome (ASS) is an idiopathic inflammatory myopathy characterized by myositis, arthritis, interstitial lung disease (ILD), Raynaud's phenomenon, and distinctive cutaneous manifestations. Anti-PL12 is a rare myositis-specific autoantibody classically associated with an amyopathic presentation and rapidly progressive ILD. Anti-Ro52 is a myositis-associated antibody that has been postulated to be directly pathogenic in inflammatory myopathy patients. The disease phenotype, course, and response to treatment associated with anti-PL12 and ...
Source: Military Medicine - November 18, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Dermatomyositis in a patient undergoing nivolumab therapy for metastatic melanoma: a case report and review of the literature
We present the case of a 63-year-old man with metastatic melanoma undergoing treatment with nivolumab who developed significant motor weakness, paresthesias of both hands, swollen fingers, and a pruritic rash over the face, chest, and upper back after two cycles. Creatine kinase was elevated. Electromyography revealed a myopathic pattern, muscle biopsy of the deltoid revealed an inflammatory myopathy, and skin biopsy showed interface dermatitis. There were no detectable autoantibodies except positive antinuclear antibody. He was diagnosed with immunotherapy-induced dermatomyositis, nivolumab was held, and he was treated wi...
Source: Melanoma Research - May 2, 2020 Category: Cancer & Oncology Tags: Short Communications Source Type: research

Anti-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody in necrotizing myopathy: treatment outcomes, cancer risk, and role of autoantibody level.
Conclusion: HMGCR Ab-positive NM patients are associated with statin exposure, have severe muscle weakness and high CK at presentation, lack other organ manifestations, and generally have favourable outcomes from immunosuppression. Anti-HMGCR Abs should be assessed in MSA-negative NM patients, particularly those with a history of statin exposure. PMID: 31801390 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - December 4, 2019 Category: Rheumatology Authors: Aggarwal R, Moghadam-Kia S, Lacomis D, Malik A, Qi Z, Koontz D, Burlingame RW, Oddis CV Tags: Scand J Rheumatol Source Type: research

Favorable Response in Statin-Naive Paraneoplastic Anti-HMGCR Antibody-Associated Myopathy to Single Dose of Rituximab and Persistent Remission With Management of Underlying Lung Cancer.
We report a case of a statin-naive paraneoplastic anti-HMGCR myopathy, who unlike other reported cases, responded to a single dose of 1000 mg of intravenous rituximab and subsequent chemoradiation therapy for an underlying lung cancer, despite failing to completely respond to prior high-dose oral prednisone and methotrexate. PMID: 31453850 [PubMed - in process]
Source: Clinical Lung Cancer - August 28, 2019 Category: Cancer & Oncology Authors: Waheed W, Jones C, Gentchos G, DeWitt J, Tandan R Tags: J Clin Neuromuscul Dis Source Type: research

Favorable Response in Statin-Naive Paraneoplastic Anti-HMGCR Antibody–Associated Myopathy to Single Dose of Rituximab and Persistent Remission With Management of Underlying Lung Cancer
We report a case of a statin-naive paraneoplastic anti-HMGCR myopathy, who unlike other reported cases, responded to a single dose of 1000 mg of intravenous rituximab and subsequent chemoradiation therapy for an underlying lung cancer, despite failing to completely respond to prior high-dose oral prednisone and methotrexate.
Source: Journal of Clinical Neuromuscular Disease - August 27, 2019 Category: Neurology Tags: Case Review Source Type: research

A case report of cyclosporine-induced myopathy with subacute muscular atrophy as initial presentation
Rationale: Cyclosporine A (CsA) is a potent immunosuppressive agent originally used to prevent rejection after organ transplantation but now more frequently used for treatment of refractory autoimmune diseases. It can induce adverse effects, such as nephrotoxicity, gastrointestinal reactions, and gingival hyperplasia whist myopathy with subacute muscular atrophy are rare. Patient concerns: A 55-year-old male patient with idiopathic membranous nephropathy treated with cyclosporine A at 3 mg/kg/d and prednisone at 0.5 mg/kg.d for more than 20 days, gradually developed lower limb weakness, which were progressively ag...
Source: Medicine - April 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Tacrolimus combined with corticosteroids effectively improved the outcome of a cohort of patients with immune-mediated necrotising myopathy.
CONCLUSIONS: Early co-administration of tacrolimus with corticosteroid promoted the remission and recovery of patients with IMNM and seemed to be a relatively safe treatment programme for physician managing immune-mediated necrotising myopathy. PMID: 30620290 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research