Dermatomyositis Associated With a Skull Base Chondrosarcoma
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Concomitant Parvimonas micra Septic Arthritis and Pseudogout After Total Knee Arthroplasty
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Cavernous Transformation and Granulomatous Epididymis in Behçet Disease
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Successful Treatment of Amyloid A–Type Amyloidosis Due to Behçet Disease With Tocilizumab
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Why Is My Foot Swollen?
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Remission of Refractory Systemic-Onset Juvenile Idiopathic Arthritis After Treatment With Siltuximab
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Neuromyelitis Optica Spectrum Disorder in a Patient With Systemic Lupus Erythematosus
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Asymmetric Calcinosis in an Adult Patient With Antisynthetase Syndrome
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Images Source Type: research

Systemic Calcinosis in NXP2-Dermatomyositis
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Images Source Type: research

Maybe Mikulicz
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Crossword Puzzle Source Type: research

Ascending Aortic Aneurysm Secondary to Isolated Noninfectious Ascending Aortitis
Isolated noninfectious ascending aortitis (I-NIAA) is increasingly diagnosed at histopathologic review after resection of an ascending aortic aneurysm. PubMed was searched using the term aortitis; publications addressing the issue were reviewed, and reference lists of selected articles were also reviewed. Eleven major studies investigated the causes of an ascending aortic aneurysm or dissection requiring surgical repair: the prevalence of noninfectious aortitis ranged from 2% to 12%. Among 4 studies of lesions limited to the ascending aorta, 47% to 81% of cases with noninfectious aortitis were I-NIAA, more frequent than Ta...
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Review Source Type: research

Systemic Sclerosis at an Intensive Care Unit: A Case Series and Literature Review
Conclusions The severity of the disease at ICU admission and comorbidity are independently associated with ICU-related mortality. Furthermore, the optimal management of SSc patients includes accurate detection of SSc-associated organ involvement. More studies involving this category of patients are needed to establish the best effective protocols. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Factors Related to Surgical Treatment and Outcomes of Thai Patients With Septic Arthritis
Objective The aim of this study was to identify factors associated with the surgical treatment of Thai patients with septic arthritis. Methods This cohort study used a university hospital database in Thailand to identify 450 adult patients with confirmed septic arthritis. Data related to baseline characteristics, clinical and laboratory findings, treatment, and outcomes were collected. A multivariate analysis identified the factors related to surgical treatment. Results The patients had a mean age (±SD) of 53.6 (±17.8) years, and 51% were male. Surgical drainage was performed on 332 patients (74%). Th...
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Increased Arterial Stiffness Adversely Affects Left Ventricular Mechanics in Patients With Pediatric Takayasu Arteritis From a Toronto Cohort
Background/Objective Takayasu arteritis (TA) is characterized by extensive aortic, large and midsize arterial wall inflammation. The aim of this study was to assess the morphological and elastic properties of the aorta and large arteries and the impact on left ventricular (LV) mechanics in children with TA. Methods Seven pediatric TA patients (6 female patients, 13.8 ± 3.2 years) were assessed with magnetic resonance imaging, vascular ultrasound, applanation tonometry, and echocardiography from February 2015 until July 2017 and compared with 7 age- and sex-matched controls. Takayasu arteritis disease activity w...
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Comparison of Adults With Polyarticular Juvenile Idiopathic Arthritis to Adults With Rheumatoid Arthritis: A Cross-sectional Analysis of Clinical Features and Medication Use
Background/Objective Many individuals with juvenile idiopathic arthritis (JIA) have persistent disease into adulthood. Polyarticular JIA (pJIA) is often mislabeled as rheumatoid arthritis (RA) in adult rheumatology clinics, and treatment for adult pJIA patients is not well defined. We aimed to describe clinical features and medication use in the adult pJIA population in relation to an RA control cohort. Methods We performed a cross-sectional study of 45 adults with pJIA and 94 with RA seen from 2013 to 2017. Clinical characteristics including RA classification criteria were compared using χ2 and McNemar tests. Med...
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

The Profile of Serum Transferrin Isoforms in Rheumatoid Arthritis
Introduction Transferrin, a microheterogeneous iron-transporting N-glycoprotein, is an optimal model for the analysis of the glycosylation profile in rheumatoid arthritis (RA). The aim of this study was to assess the transferrin isoforms profile in RA patients at the time of diagnosis and then look into their associations with disease activity. Methods Serum samples were collected from 48 patients with RA. The patients were males (6) and females (42) (age range: 33–85 years). Control group consisted of 30 healthy volunteers. Transferrin isoforms were analysed by capillary electrophoresis on MINICAP electrophoret...
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Medical Scientific Publications From Latin America: A Commentary
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 29, 2019 Category: Rheumatology Tags: Editorial Source Type: research

Stiff-Types
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Crossword Puzzle Source Type: research

Gout in the Gilded Age: The Case of Richard Morris Hunt
Richard Morris Hunt, a distinguished American architect of the late 19th century (the Gilded Age), had onset of gout at age 41 years. His attacks became more frequent and severe, eventually leading to chronic pain and disability. His medical care by highly regarded physicians resulted in very limited benefit, but through his dedication and work ethic, he remained productive until his death at age 67 years. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Rheumatology Retrospective Source Type: research

Ultrasound-Guided Interventions in Lateral Epicondylitis
Lateral epicondylitis is a painful condition related to the myotendinous origin of the extensor muscles at the lateral epicondyle of the humerus. Primary treatment typically involves the use of rest, non-steroidal anti-inflammatory drugs (NSAIDs), and physiotherapy. However, in refractory cases where conventional therapy is ineffective, ultrasound-guided injection therapies have become a growing form of treatment. These include needle tenotomy, autologous whole blood injection (AWB), platelet-rich plasma (PRP) injection and steroid injection. The consensus regarding the efficacy of individual approaches of ultrasound-guide...
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Reviews Source Type: research

Lymphocytic Thrombophilic Arteritis: A Review
Macular lymphocytic arteritis or lymphocytic thrombophilic arteritis (LTA) is a recently described cutaneous arteritis that is characterized by asymptomatic macules and patches of the extremities associated with lymphocytic arteritis at the deep dermal/subcuticular junction for which little information exists on demographics, evaluation, and management. There has been recent debate in the literature whether this disease is a new distinct entity, misdiagnosed cutaneous polyarteritis nodosa (cPAN), or a disease on a spectrum with cPAN. We systematically review the literature on demographic information, medical history, histo...
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Reviews Source Type: research

Clinical Profile of Levamisole-Adulterated Cocaine-Induced Vasculitis/Vasculopathy: A 30-Case Series
Conclusions Because of rising cocaine consumption and levamisole adulteration frequency, levamisole-adulterated cocaine-induced vasculitis/vasculopathy is becoming more common. Detailed characterization of skin involvement coupled with multiple antibody positivity is essential for a diagnosis. Renal involvement is frequent, clinically and histologically heterogeneous, and potentially serious. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Nailfold Videocapillaroscopy Changes Are Associated With the Presence and Severity of Systemic Sclerosis–Related Interstitial Lung Disease
Conclusions Capillary loss and avascular area showed a significant association with the presence of ILD, supported by ROC curve analysis. These results may reinforce a prognostic role for NVC and a physiopathology mechanism for ILD based on vascular damage. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Obesity Impacts Swelling of Ankle and Foot Joints in Early Rheumatoid Arthritis Patients
This study examines the effect of obesity on the American College of Rheumatology (ACR) core set measures used in assessing RA disease activity with specific focus on the swollen joint count (SJC). Methods We examined a cross-sectional cohort of 323 early seropositive RA patients (symptom duration ≤15 months). Patients were biologic-naive with equal to or more than 6/44 SJC and equal to or more than 9/44 tender joint count. The ACR core set measures, components of Disease Activity Score (DAS) 44/erythrocyte sedimentation rate (ESR), DAS28/ESR4 item, Clinical Disease Activity Index (CDAI), and body mass index (BMI) we...
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Assessing Unwanted Variations in Rheumatology Clinic Previsit Rooming
Background Rheumatologists face time pressures similar to primary care but have not generally benefitted from optimized team-based rooming during the time from the waiting room until the rheumatologist enters the room. Objective The aim of this study was to assess current capacity for population management in rheumatology clinics; we aimed to measure the tasks performed by rheumatology clinic staff (medical assistants or nurses) during rooming. Methods We performed a cross-sectional time-study and work-system analysis to measure rooming workflows at 3 rheumatology clinics in an academic multispecialty practice duri...
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Planning for the Rheumatologist Workforce: Factors Associated With Work Hours and Volumes
Objective The aim of this study was to evaluate factors associated with rheumatologists' clinical work hours and patient volumes based on a national workforce survey in rheumatology. Methods Adult rheumatologists who participated in a 2015 workforce survey were included (n = 255). Univariate analysis evaluated the relationship between demographics (sex, age, academic vs. community practice, billing fee for service vs. other plan, years in practice, retirement plans) and workload (total hours and number of ½-day clinics per week) or patient volumes (number of new and follow-up consults per week). Multiple linear...
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Mobile Apps for Individuals With Rheumatoid Arthritis: A Systematic Review
Conclusions Most current RA apps do not provide a comprehensive experience for individuals with RA. Areas for optimization include the implementation of smartphone accessibility features and secure methods of protecting individual health information. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Women's Health Initiative Observational Cohort
Conclusions In a large prospective cohort of older women, there was no association between coffee consumption and incident RA. A small association between daily caffeinated, nonherbal tea consumption and incident RA was found. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Tofacitinib 5 mg Twice Daily in Patients with Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs: A Comprehensive Review of Phase 3 Efficacy and Safety
Conclusions Tofacitinib 5 mg BID reduced RA signs and symptoms and improved physical function versus placebo in patients with inadequate response to prior disease-modifying antirheumatic drugs. Tofacitinib 5 mg BID had a consistent, manageable safety profile across studies, with no new safety signals identified. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - March 29, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Factors Associated With Initiation of Biologics in Patients With Axial Spondyloarthritis in an Urban Asian City: A PRESPOND Study
Objective The aim of this study was to examine if patients' sociodemographic, clinical characteristics, and patient-reported outcomes were associated with biologics initiation in patients with axial spondyloarthritis in Singapore. Methods Data from a dedicated registry from a tertiary referral center in Singapore from January 2011 to July 2016 were used. Initiation of first biologics was the main outcome of interest. Logistic regression analyses were used to explore the association of various factors on biologics initiation. Results Of 189 eligible patients (aged 37.7 ± 13.3 years; 76.2% were males), 30 (15....
Source: JCR: Journal of Clinical Rheumatology - March 1, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Thank You to Our 2018 Reviewers!
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 28, 2019 Category: Rheumatology Tags: Thank You to Our 2018 Reviewers Source Type: research

Thanks to our 2018 Reviewers
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Thank You to Our 2018 Reviewers Source Type: research

Oh My Aching Muscles
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Crossword Puzzle Source Type: research

Auguste Renoir, Sculptor With Hired Hands: A Masterful Artistic Cooperation Overshadowed by Legal Issues and Copyright Infringement
The coping with rheumatoid arthritis of the famous French impressionist painter Pierre-Auguste Renoir (1841–1919) is described in former publications. The heavily handicapped painter has in his last years created sculptures in cooperation with the sculptor Richard Guino (1890–1973). The extraordinary genesis of the sculptures through a masterful artistic cooperation, as well as the resulting legal issues and shameful copyright infringements, is reported. Renoir's decision to create sculptures with the help of Guido can be attributed to his remarkable artistic vision, vitality, optimistic nature, and strong will...
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Rheumatology Retrospective Source Type: research

Pan-American League of Associations for Rheumatology–Central American, Caribbean and Andean Rheumatology Association Consensus-Conference Endorsements and Recommendations on the Diagnosis and Treatment of Chikungunya-Related Inflammatory Arthropathies in Latin America
Background/Objective Although mortality rates related with chikungunya (CHIK) outbreaks in Latin America's (LA's) dengue-endemic rural and new urban regions are low, dealing with symptoms and sequelae can both produce a significant burden of disease and diminish quality of life—from many months to years—after the acute phase of the infection, with a significant impact on public and individual health. The aim of this work was to establish Pan-American League of Associations for Rheumatology–Central American, Caribbean and Andean Rheumatology Association (ACCAR) consensus-conference endorsements and reco...
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Practice and Health Policy Source Type: research

Practical Guidance on Biosimilars, With a Focus on Latin America: What Do Rheumatologists Need to Know?
Conclusions and Future Directions Practicing rheumatologists in Latin America need to understand the regulatory situation for biosimilars in their countries. When considering bDMARDs that are not innovator products, clinicians should use only those that have been approved according to the WHO recommendations. For clarification, local health authorities or professional associations should be contacted. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Review Source Type: research

Role of Interleukin 37 as a Novel Proangiogenic Factor in Juvenile Idiopathic Arthritis
Objective The aim of this study was to investigate interleukin 37 (IL-37) levels in the serum and synovial fluid of patients with juvenile idiopathic arthritis (JIA), its expression in peripheral blood mononuclear cells, and correlation with disease activity and angiogenesis. Methods Seventy JIA patients and 50 control subjects were examined. The Juvenile Arthritis Disease Activity Score in 27 joints (JADAS-27) was calculated. Immunoassays were used to measure the serum and synovial fluid levels of IL-37, vascular endothelial growth factor (VEGF), soluble VEGF receptor 1 (sVEGF-R1), and sVEGF-R2. Relative expression o...
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Validation of a Quality of Life Instrument in Spanish Patients With Rheumatic Diseases: The Rosser Classification System
Conclusions The Rosser classification system showed satisfactory reliability and suitable criterion validity for patients with musculoskeletal disorders. The instrument seems to be suitable for clinical decision making and research. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Constrictive Bronchiolitis in Patients With Primary Sjögren Syndrome
Conclusions Constrictive bronchiolitis is a rare extraglandular manifestation and can sometimes be the presenting manifestation of pSS. This pulmonary manifestation is associated with an indolent clinical course and does not respond well to immunosuppressive therapy. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Sacroiliitis in Children With Familial Mediterranean Fever
Conclusions Sacroiliitis can be seen in patients with FMF during childhood, and M694V mutation seems to be a susceptibility factor for its development. Inflammatory low-back pain and leg and heel pain could suggest sacroiliitis. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Evaluation of Learned Helplessness, Perceived Self-efficacy, and Functional Capacity in Patients With Fibromyalgia and Rheumatoid Arthritis
Conclusions Both LH and SE correlate significantly with functional capacity, perceived pain, disease activity, and disease impact in RA and FM patients. Learned helplessness was higher in patients with active disease or high disease impact, as opposed to those in remission or with low disease impact, and the reverse was true for SE. Patients with FM had significantly more LH, pain, fatigue, and depression and less SE compared with those with RA. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

Factors Associated With Initiation of Biologics in Patients With Axial Spondyloarthritis in an Urban Asian City: A PRESPOND Study
Objective The aim of this study was to examine if patients' sociodemographic, clinical characteristics, and patient-reported outcomes were associated with biologics initiation in patients with axial spondyloarthritis in Singapore. Methods Data from a dedicated registry from a tertiary referral center in Singapore from January 2011 to July 2016 were used. Initiation of first biologics was the main outcome of interest. Logistic regression analyses were used to explore the association of various factors on biologics initiation. Results Of 189 eligible patients (aged 37.7 ± 13.3 years; 76.2% were males), 30 (15....
Source: JCR: Journal of Clinical Rheumatology - February 26, 2019 Category: Rheumatology Tags: Original Articles Source Type: research

A Consensus Position Paper From REAL-PANLAR Group About the Methodological Approach for the Accreditation Process of Centers of Excellence in Rheumatoid Arthritis in Latin America
Conclusions This is the second REAL-PANLAR consensus paper with the purpose to define the parameters for the accreditation process for future CoE in RA in LA. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - December 23, 2018 Category: Rheumatology Tags: Practice and Health Policy Source Type: research

Prevalence of Crystals in Knee Osteoarthritis: Experience From Patients Undergoing Arthroscopic Procedures
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - December 23, 2018 Category: Rheumatology Tags: Concise Report Source Type: research

Team Effort
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - December 23, 2018 Category: Rheumatology Tags: Crossword Puzzle Source Type: research

Prevalence and Associations of Avascular Necrosis of the Hip in a Large Well-characterized Cohort of Patients With Inflammatory Bowel Disease
Conclusions We found that a significant proportion of IBD patients with AVN are reported in their records as having hip or low-back pain, and review of CT imaging under dedicated bone windows may identify AVN among this population. Our findings also suggest that additional etiological factors, beyond corticosteroids, contribute to the development of AVN in IBD. Further investigation is warranted regarding the mechanisms associated with AVN in IBD. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - December 23, 2018 Category: Rheumatology Tags: Original Articles Source Type: research

Outcomes, Satisfaction, and Costs of a Rheumatology Telemedicine Program: A Longitudinal Evaluation
Objectives Rural veterans with inflammatory arthritis (IA) lack medical access because of geographic barriers. Telemedicine (TM) holds great promise in relieving these disparities. We have prospectively measured patient-centered data surrounding a TM care program at a federal health system and compared these with usual care (UC). Methods Veterans with previously established IA were enrolled in TM follow-up. Data collected longitudinally before and after entering the program included Routine Assessment of Patient Index Data 3 (RAPID-3), out-of-pocket visit costs and distances traveled, and patient satisfaction instrume...
Source: JCR: Journal of Clinical Rheumatology - December 23, 2018 Category: Rheumatology Tags: Original Articles Source Type: research

A New Comorbidity in Female Patients With Ankylosing Spondylitis: Pelvic Organ Prolapse
Conclusions The incidence of POP is higher among patients with AS compared with normal population. These patients should be questioned about the symptoms of POP and recommended, if necessary, regular gynecological examinations, as well as specific exercises including those targeting AS. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - December 23, 2018 Category: Rheumatology Tags: Original Articles Source Type: research

Cyclophosphamide Versus Mycophenolate Versus Rituximab in Lupus Nephritis Remission Induction: A Historical Head-to-Head Comparative Study
We report comparative efficacy between high-dose cyclophosphamide (HDCyC), low-dose cyclophosphamide (LDCyC), mycophenolate mofetil (MMF) and rituximab in patients with lupus nephritis (LN). Methods We analyzed comparative efficacy of 4 induction regimens of biopsy-proven LN: LDCyC: 500 mg fortnightly, HDCyC: 750 to 1200 mg monthly, MMF: 1.5 to 3 g/d, and rituximab. Outcomes of 4 groups were analyzed at the sixth month. Results Among a total 222 patients, 26 received LDCyC (3-g total dose), 113 received HDCyC (mean, 5.1-g total dose), 61 received MMF (mean, 2.2 g/d), and 22 received rituximab (mean, 1.9-g total dose)...
Source: JCR: Journal of Clinical Rheumatology - December 23, 2018 Category: Rheumatology Tags: Original Articles Source Type: research

ASCA (Anti-Saccharomyces cerevisiae Antibody) in Patients With Scleroderma
In this study we aimed to investigate ASCA positivity in SSc patients and its association with clinical, serological and epidemiological data. Methods Seventy-four SSc patients and 57 healthy controls were studied for ASCA (IgG and IgA) positivity by ELISA. ASCA positivity was associated with demographic, clinical severity index (by Medsger score) and serological data in SSc patients. Results ASCA-IgG was positive in 32/74 (43.2%) patients of the SSc group and 1/57 (1.7%) of controls (p (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - December 23, 2018 Category: Rheumatology Tags: Original Articles Source Type: research