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Statin-Associated Polymyositis Following Omeprazole Treatment.
Abstract Statins are an extensively used class of drugs, and myopathy is an uncommon, but well-described side effect of statin therapy. Inflammatory myopathies, including polymyositis, dermatomyositis, and necrotizing autoimmune myopathy, are even rarer, but debilitating, side effects of statin therapy that are characterized by the persistence of symptoms even after discontinuation of the drug. It is important to differentiate statin-associated inflammatory myopathies from other self-limited myopathies, as the disease often requires multiple immunosuppressive therapies. Drug interactions increase the risk of stati...
Source: Clinical Medicine and Research - April 12, 2013 Category: Journals (General) Authors: Kanth R, Shah MS, Flores RM Tags: Clin Med Res Source Type: research

Therapy of myositis.
Abstract Idiopathic inflammatory myopathy consists of dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM). At all stages of myositis, physiotherapy is effective in improving muscle strength, endurance and in maintaining joint motion. In DM and PM the therapy is initiated with glucocorticosteroids. Steroid-sparing agents (azathioprine, methotrexate and cyclosporin A) are added to prevent Cushing's syndrome or an unsatisfactory response. Therapy can also be escalated with intravenous immunoglobulins. Tacrolimus and mycophenolate mofetil (MMF) were effectiv...
Source: Zeitschrift fur Rheumatologie - April 1, 2013 Category: Rheumatology Authors: Keck AD, Walker UA Tags: Z Rheumatol Source Type: research

Ciclosporin/prednisone: Acute renal failure and myopathy: case report
Source: Reactions - January 28, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

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