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Therapy: Antiviral Therapy

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Total 305 results found since Jan 2013.

Antiviral therapy of coronavirus disease 2019 (COVID-19)
J Formos Med Assoc. 2023 Sep 2:S0929-6646(23)00342-X. doi: 10.1016/j.jfma.2023.08.029. Online ahead of print.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has reached a turning point. The non-pharmaceutical interventions for preventing COVID-19 are lifting. Vaccination uptake is increasing in general, but this strategy is continuously challenged by the rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Of note, the Omicron subvariants spread globally for at least one year, and the most recently developed subvariants show strong immune evasion to preexisting immunity, either from pre...
Source: J Formos Med Assoc - September 4, 2023 Category: General Medicine Authors: Pao-Yu Chen Jann-Tay Wang Shan-Chwen Chang Source Type: research

SARS ‐CoV‐2 viral dynamic modeling to inform model selection and timing and efficacy of antiviral therapy
In this study, eight published viral dynamic models were assessed, and model selection was performed. Viral load data were collected from a community surveillance study, including 2155 measurements from 162 patients (124 household and 38 non-household contacts). An extended version of the target-cell limited model that includes an eclipse phase and an immune response component that enhances viral clearance described best the data. In general, the parameter estimates showed good precision (relative standard error<10), apart from the death rate of infected cells. The parameter estimates were used to simulate the outcomes ...
Source: CPT: Pharmacometrics and Systems Pharmacology - August 23, 2023 Category: Drugs & Pharmacology Authors: Shengyuan Zhang, Akosua A. Agyeman, Christoforos Hadjichrysanthou, Joseph F. Standing Tags: ARTICLE Source Type: research

Management of chronic myelogenous leukemia with COVID-19 and hepatitis B
This article also provides an overview of TKI-related hepatitis B reactivation. If not managed, patients may face adverse consequences such as hepatitis B reactivation-related hepatitis, liver failure, and progression of CML after forced withdrawal of medication. Therefore, this review aimed to comprehensively describe the management of CML patients with comorbid COVID-19, the pathogenesis of hepatitis B reactivation, the indicated population for prophylactic antiviral therapy, the time of antiviral drug discontinuation, and drug selection.
Source: Frontiers in Oncology - August 3, 2023 Category: Cancer & Oncology Source Type: research

In Silico Identification and Analysis of Potentially Bioactive Antiviral Phytochemicals against SARS-CoV-2: A Molecular Docking and Dynamics Simulation Approach
Biomed Res Int. 2023 May 11;2023:5469258. doi: 10.1155/2023/5469258. eCollection 2023.ABSTRACTSARS-CoV-2, a deadly coronavirus sparked COVID-19 pandemic around the globe. With an increased mutation rate, this infectious agent is highly transmissible inducing an escalated rate of infections and death everywhere. Hence, the discovery of a viable antiviral therapy option is urgent. Computational approaches have offered a revolutionary framework to identify novel antimicrobial treatment regimens and allow a quicker, cost-effective, and productive conversion into the health center by evaluating preliminary and safety investigat...
Source: Biomed Res - May 22, 2023 Category: Research Authors: Sajal Kumar Halder Ive Sultana Md Nazmussakib Shuvo Aparna Shil Mahbubul Kabir Himel Md Ashraful Hasan Mohammad Mahfuz Ali Khan Shawan Source Type: research

Prevalence of inappropriate use of nirmatrelvir-ritonavir antiviral therapy in hospitalized patients: A multicenter retrospective study in China
CONCLUSIONS: The proportion of inappropriate use of NMVr was particularly high in the Chinese hospital setting, highlighting the urgent need to improve the appropriate use of NMVr.PMID:37211263 | DOI:10.1016/j.ijantimicag.2023.106857
Source: Cancer Control - May 21, 2023 Category: Cancer & Oncology Authors: Changcheng Shi Lei Qiu Juanjuan Zhuo Yingying Fang Limin Wang Junbo Xia Shuying Wang Qing Luo Kang Zhou Yongchen Li Qingyu Li Gang Wang Nengming Lin Source Type: research

Dextran sulfate from Leuconostoc mesenteroides B512F exerts potent antiviral activity against SARS-CoV-2 in vitro and in vivo
The emergent human coronavirus SARS-CoV-2 and its resistance to current drugs makes the need for new potent treatments for COVID-19 patients strongly necessary. Dextran sulfate (DS) polysaccharides have long demonstrated antiviral activity against different enveloped viruses in vitro. However, their poor bioavailability has led to their abandonment as antiviral candidates. Here, we report for the first time the broad-spectrum antiviral activity of a DS-based extrapolymeric substance produced by the lactic acid bacterium Leuconostoc mesenteroides B512F. Time of addition assays with SARS-CoV-2 pseudoviruses in in vitro model...
Source: Frontiers in Microbiology - May 3, 2023 Category: Microbiology Source Type: research

Nirmatrelvir/ritonavir (Paxlovid ®): French pharmacovigilance survey 2022
CONCLUSION: Overall, this analysis shows that nirmatrelvir/ritonavir safety profile was conform to current summary of product characteristics (SmPC). The main concern was the risk of DDI. Therefore, SmPC and expert recommendations should be systematically consulted before initiation of this antiviral, which is particularly indicated in polypharmacy patients. A case-by-case multidisciplinary approach including a clinical pharmacologist is required in these complex situations. Blood pressure elevation, confusion, cutaneous reactions and AKIs were the main unexpected ADRs of interest to follow, but need to be confirmed with a...
Source: Therapie - April 3, 2023 Category: Psychiatry & Psychology Authors: Kevin Bihan Lor ène Lipszyc Florian Lemaitre Anne Dautriche Sophie F édrizzi Marina Atzenhoffer Aur élie Vitores Annabelle Page B énédicte Lebrun-Vignes Source Type: research

Viruses, Vol. 15, Pages 693: Prolonged SARS-CoV-2 Infection and Organizing Pneumonia in a Patient with Follicular Lymphoma, Treated with Obinutuzumab & mdash;Challenging Recognition and Treatment
We present a case report of a patient with follicular lymphoma, treated with obinutuzumab, who was diagnosed with prolonged, ongoing SARS-CoV-2 infection and related organizing pneumonia. The recognition and the treatment were challenging which makes this case noteworthy. Antiviral therapy with several medications was administrated to our patient and their temporary, positive effect was observed. Moreover, high-dose intravenous immunoglobulin was applied, because slowly decreasing IgM and IgG levels were observed. The patient also received standard treatment of organizing pneumonia. We believe that such a complex approach ...
Source: Viruses - March 7, 2023 Category: Virology Authors: E. Łyżwa M. Sobiecka K. Lewandowska I. Siemion-Szcze śniak I. Bara ńska M. Klatt R. Langfort M. Szturmowicz W. Tomkowski Tags: Case Report Source Type: research

Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: New tricks for old dogs
Antiviral Res. 2023 Mar 1:105575. doi: 10.1016/j.antiviral.2023.105575. Online ahead of print.ABSTRACTWith the resurgence of the coronavirus pandemic, the repositioning of FDA-approved drugs against coronovirus and finding alternative strategies for antiviral therapy are both important. We previously identified the viral lipid envelope as a potential target for the prevention and treatment of SARS-CoV-2 infection with plant alkaloids (Shekunov et al., 2021). Here, we investigated the effects of eleven cyclic lipopeptides (CLPs), including well-known antifungal and antibacterial compounds, on the liposome fusion triggered b...
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Egor V Shekunov Polina D Zlodeeva Svetlana S Efimova Anna A Muryleva Vladimir V Zarubaev Alexander V Slita Olga S Ostroumova Source Type: research