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Therapy: Antiviral Therapy
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Total 305 results found since Jan 2013.
A Case of Heart Transplantation for Fulminant Myocarditis After ChAdOx1 nCoV-19 Vaccination
J Korean Med Sci. 2022 Apr 4;37(13):e104. doi: 10.3346/jkms.2022.37.e104.ABSTRACTVaccines have become the mainstay of management against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019; COVID-19) in the absence of effective antiviral therapy. Various adverse effects of COVID-19 vaccination have been reported, including cardiovascular complications such as myocarditis or pericarditis. Herein, we describe clinical records of a 63-year woman with fulminant myocarditis following ChAdOx1 nCoV-19 vaccination that was salvaged by heart transplantation. She complained chest pain, na...
Source: J Korean Med Sci - April 5, 2022 Category: General Medicine Authors: Seok Hyun Kim Soo Yong Lee Ga Yun Kim Ji Soo Oh Jeongsu Kim Kook Jin Chun Min Ho Ju Chee-Hoon Lee Yeo-Jeong Song Joo-Young Na Source Type: research
Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol
J Inorg Biochem. 2022 Mar 1;231:111777. doi: 10.1016/j.jinorgbio.2022.111777. Online ahead of print.ABSTRACTThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic is currently the major challenge to global public health. Two proteases, papain-like protease (PLpro) and the 3-chymotrypsin-like protease (3CLpro or Mpro), are indispensable for SARS-CoV-2 replication, making them attractive targets for antiviral therapy development. Here we screened a panel of essential metal ions using a proteolytic assay and identified that zinc gluconate, a widely-used zinc supplement, strongly inhibited the proteolytic ac...
Source: Journal of Inorganic Biochemistry - March 7, 2022 Category: Biochemistry Authors: Xuan Tao Lu Zhang Liubing Du Kai Lu Zhennan Zhao Yanxuan Xie Xiaobo Li Shuxiang Huang Pei-Hui Wang Ji-An Pan Wei Xia Jun Dai Zong-Wan Mao Source Type: research
COVID-19 immunotherapy: Treatment based on the immune cell-mediated approaches
Int Immunopharmacol. 2022 Feb 25;107:108655. doi: 10.1016/j.intimp.2022.108655. Online ahead of print.ABSTRACTMultiple efforts are currently underway to control and treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19) worldwide. Despite all efforts, the virus that emerged in Wuhan city has rapidly spread globally and led to a public health emergency of international concern (PHEIC) due to the lack of approved antiviral therapy. Nevertheless, SARS-CoV-2 has had a significant influence on the evolution of cellular therapeutic approaches. Adoptive immune cell therapy ...
Source: International Immunopharmacology - March 6, 2022 Category: Allergy & Immunology Authors: Mahdi Zavvar Aisan Yahyapoor Hamed Baghdadi Sina Zargaran Sara Assadiasl Kamal Abdolmohammadi Amir Hossein Abooei Mohammad Reza Sattarian Melina JalaliFarahani Negar Zarei Amirali Farahvash Yousef Fatahi Gunnur Deniz Mitra Zarebavani Mohammad Hossein Nick Source Type: research
Comorbidities Associated with Hospitalization and Progression Among Adolescents with Symptomatic Coronavirus Disease 2019
To identify subgroups likely to benefit from monoclonal antibody and antiviral therapy by evaluating the relationship between comorbidities and hospitalization among US adolescents with symptomatic coronavirus disease 2019 (COVID-19).
Source: The Journal of Pediatrics - February 28, 2022 Category: Pediatrics Authors: Jeffrey I. Campbell, Melanie M. Dubois, Timothy J. Savage, M. Indriati Hood-Pishchany, Tanvi S. Sharma, Carter R. Petty, Gabriella S. Lamb, Mari M. Nakamura, Pediatric COVID-19 US Registry Tags: Original Article Source Type: research
Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict β-coronaviral infection and replication
Virology. 2022 Feb 15;569:13-28. doi: 10.1016/j.virol.2022.01.002. Online ahead of print.ABSTRACTEmerging mutations in the SARS-CoV-2 genome pose a challenge for vaccine development and antiviral therapy. The antiviral efficacy of Azadirachta indica bark extract (NBE) was assessed against SARS-CoV-2 and m-CoV-RSA59 infection. Effects of in vivo intranasal or oral NBE administration on viral load, inflammatory response, and histopathological changes were assessed in m-CoV-RSA59-infection. NBE administered inhibits SARS-CoV-2 and m-CoV-RSA59 infection and replication in vitro, reducing Envelope and Nucleocapsid gene expressi...
Source: Virology - February 26, 2022 Category: Virology Authors: Lucky Sarkar Lauren Oko Soham Gupta Andrew N Bubak Bishnu Das Parna Gupta Abass Alao Safiriyu Chirag Singhal Ujjwal Neogi David Bloom Arup Banerjee Ravi Mahalingam Randall J Cohrs Michael Koval Kenneth S Shindler Debnath Pal Maria Nagel Jayasri Das Sarma Source Type: research
Reactivation of Herpes Simplex Virus Type 1 (HSV-1) Detected on Bronchoalveolar Lavage Fluid (BALF) Samples in Critically Ill COVID-19 Patients Undergoing Invasive Mechanical Ventilation: Preliminary Results from Two Italian Centers
In conclusion, HSV-1 reactivation is frequently detected in intubated patients with COVID-19. An antiviral treatment in COVID-19 patients with HSV-1 reactivation and worsening respiratory function might be considered.PMID:35208817 | DOI:10.3390/microorganisms10020362
Source: Herpes - February 25, 2022 Category: Infectious Diseases Authors: Daniele Roberto Giacobbe Stefano Di Bella Silvia Dettori Giorgia Brucci Verena Zerbato Riccardo Pol Ludovica Segat Pierlanfranco D'Agaro Erik Roman-Pognuz Federica Friso Luigi Principe Umberto Lucangelo Lorenzo Ball Chiara Robba Denise Battaglini Andrea D Source Type: research
